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Article

Significance of E-cadherin and CD44 expression in patients with unresectable metastatic colorectal cancer

  • Authors:
    • Yasuhito Iseki
    • Masatsune Shibutani
    • Kiyoshi Maeda
    • Hisashi Nagahara
    • Tetsuro Ikeya
    • Kosei Hirakawa
  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545‑8585, Japan
  • Pages: 1025-1034
    |
    Published online on: May 26, 2017
       https://doi.org/10.3892/ol.2017.6269
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Abstract

The loss of adhesion molecules is reported to be associated with tumor invasion and metastasis in numerous types of cancer. Epithelial (E)‑cadherin is an important molecule for cell‑to‑cell adhesion, while cluster of differentiation (CD)44 is an important molecule for cell‑to‑extracellular matrix adhesion. The focus of the present study was to evaluate the significance of the expression of E‑cadherin and CD44 in patients with the unresectable metastatic colorectal cancer (CRC) who are undergoing palliative chemotherapy. Formalin‑fixed, paraffin‑embedded samples were obtained from 49 patients who underwent primary tumor resection and who were receiving palliative chemotherapy for unresectable metastatic CRC. The expression of E‑cadherin and CD44 was evaluated using immunohistochemistry. The expression of E‑cadherin was not significantly associated with progression‑free survival (PFS; P=0.2825) or overall survival (OS; P=0.6617). The expression of CD44 was not associated with PFS (P=0.4365), but it did exhibit a certain level of association with OS (P=0.0699). However, the combined low expression of E‑cadherin and CD44 demonstrated a significant association with decreased PFS (P=0.0101) and OS (P=0.0009). The combined loss of E‑cadherin and CD44 expression also led to a reduction in the objective response rate and disease control rate (P=0.0076 and P=0.0294, respectively). A univariate analysis indicated that the combined low expression of E‑cadherin and CD44 (P=0.0474) and sex (P=0.0330) were significantly associated with decreased PFS, and multivariate analysis confirmed combined low expression of E‑cadherin and CD44 as an independent risk factor for decreased PFS [hazard ratio (HR), 8.276; 95% confidence interval (CI), 1.383‑43.311; P=0.0227]. Univariate and multivariate analyses also indicated that the combined low expression of E‑cadherin and CD44 expression was a significant prognostic factor for poor OS (HR, 15.118; 95% CI, 2.645‑77.490; P=0.0039). Therefore the current study suggests that the combined low expression of E‑cadherin and CD44 is an effective independent predictor of decreased chemotherapeutic outcome and survival in patients with unresectable metastatic CRC.
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1 

Matsuda A, Matsuda T, Shibata A, Katanoda K, Sobue T and Nishimoto H; Japan Cancer Surveillance Research Group, : Cancer incidence and incidence rates in Japan in 2008: A study of 25 population-based cancer registries for the monitoring of cancer incidence in Japan (MCIJ) project. Jpn J Clin Oncol. 44:388–396. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Heinemann V, von Weikersthal LF, Decker T, Kiani A, Vehling-Kaiser U, Al-Batran SE, Heintges T, Lerchenmüller C, Kahl C, Seipelt G, et al: FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): A randomised, open-label, phase 3 trial. Lancet Oncol. 15:1065–1075. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Loupakis F, Cremolini C, Masi G, Lonardi S, Zagonel V, Salvatore L, Cortesi E, Tomasello G, Ronzoni M, Spadi R, et al: Initial therapy with FOLFOXIRI and bevacizumab for metastatic colorectal cancer. N Engl J Med. 371:1609–1618. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Beavon IR: The E-cadherin-catenin complex in tumour metastasis: Structure, function and reglation. Eur J Cancer. 36:1607–1620. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Ponta H, Sherman L and Herrlich PA: CD44: From adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol. 4:33–45. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Ngan CY, Yamamoto H, Seshimo I, Ezumi K, Terayama M, Hemmi H, Takemasa I, Ikeda M, Sekimoto M and Monden M: A Multivariate analysis of adhesion molecules expression in assessment of colorectal cancer. J Surg Oncol. 95:652–662. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Lugli A, Lezzi G, Hostettler I, Murano MG, Mele V, Tornillo L, Carafa V, Spagnoli G, Terracciano L and Zlobec I: Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer. Br J Cancer. 103:382–390. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Sugino T, Gorham H, Yoshida K, Bolodeoku J, Nargund V, Cranston D, Goodison S and Tarin D: Progressive loss of CD44 gene expression in invasive bladder cancer. Am J Pathol. 149:873–882. 1996.PubMed/NCBI

9 

Bhangu A, Wood G, Beown G, Darzi A, Tekkis P and Goldin R: The role of epithelial mesenchymeal transition and resistance to neoadjuvant therapy in localy advanced rectal cancer. Colorectal Dis. 16:O133–O143. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Dorudi S, Sheffield JP, Pouulsom R, Northover JM and Hart IR: E-cadherin expression in colorectal cancer: An immunetochemical and in situ hybridization study. Am J Pathol. 142:981–986. 1993.PubMed/NCBI

11 

Ghadimi BM, Behrens J, Hoffman I, Haensch W, Birchmeier W and Schlag PM: Immunohistological analysis of E-cadherin, alpha-, beta- and gamma-catenin expression in colorectal cancer: Implications for cell adhesion and signaling. Eur J Cancer. 35:60–65. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Wheelock MJ, Shintani Y, Maeda M, Fukumoto Y and Johnson KR: Cadherin switching. J Cell Sci. 121:727–735. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Shintani Y, Maeda M, Chaika N, Johnson KR and Wheelock MJ: Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth-factor signaling. Am J Respir Cell Mol Biol. 38:95–104. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Suyama K, Shapiro I, Guttman M and Hazan RB: A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor. Cancer Cell. 2:301–314. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Kanwar SS, Yu Y, Nautiyal J, Patel BB and Majumdar AP: The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres. Mol Cancer. 9:2122010. View Article : Google Scholar : PubMed/NCBI

16 

Miyake K, Underhill CB, Lesley J and Kincade PW: Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition. J Exp Ned. 172:69–75. 1990. View Article : Google Scholar

17 

Aruffo A, Stamenkovic I, Melnick M, Underhill CB and Seed B: CD44 is the principal cell surface receptor for hyaluronate. Cell. 61:1303–1313. 1990. View Article : Google Scholar : PubMed/NCBI

18 

Dougherty GJ, Lansdorp PM, Cooper DL and Humphries RK: Molecular cloning of CD44R1 and CD44R2, two novel isoforms of the human CD44 lymphocyte ‘homing’ receptor expressed by hemopoietic cells. J Exp Med. 174:1–5. 1991. View Article : Google Scholar : PubMed/NCBI

19 

Goldstein LA, Zhou DF, Picker LJ, Minty CN, Bargatze RF, Ding JF and Butcher EC: A human lymphocyte homin receptor, the hermes antigen, is related to cartel proteoglycan core anf link proteins. Cell. 56:1063–1072. 1989. View Article : Google Scholar : PubMed/NCBI

20 

Stamenkovic I, Amiot M, Pesando JM and Seed B: A lymphocyte molecule implicated in lymph node homing is a member of the cartel link protein family. Cell. 56:1057–1062. 1989. View Article : Google Scholar : PubMed/NCBI

21 

Marhaba R and Zöller M: CD44 and in cancer progression: Adhesion, migration and growth regulation. J Mol Histol. 35:211–231. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Sugano K, Maeda K, Ohtani H, Nagahara H, Shibutani M and Hirakawa K: Expression of xCT as a predictor of disease recurrence in patients with colorectal cancer. Anticancer Res. 35:677–682. 2015.PubMed/NCBI

23 

Al-Maghrabi J, Gomaa W, Buhmeida A, Al-Qahtani M and Al-Ahwal M: Decreased immunoexpression of standard form of CD44 is an independent favourable predictor of nodal metastasis in colorectal carcinoma. Anticancer Res. 32:3455–3461. 2012.PubMed/NCBI

24 

Jayne DG, Fook S, Loi C and Seow-Choen F: Peritoneal carcinomatosis from colorectal cancer. Br J Surg. 89:1545–1550. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Kobayashi H, Kotake K and Sugihara K: Prognostic scoring system for stage IV colorectal cancer: Is the AJCC sub-classification of stage IV colorectal cancer appropriate? Int J Clin Oncol. 18:696–703. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Barker N and Clevers H: Tumor environment: A potent driving force in colorectal cancer? Trends Mol Med. 7:535–537. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Hur K, Toiyama Y, Takahashi M, Balaguer F, Nagasaka T, Koike J, Hemmi H, Koi M, Boland CR and Goel A: MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis. Gut. 62:1315–1326. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Bates RC: Colorectal cancer progression: Integrin alphavbeta6 and the epithelial-mesenchymal transition (EMT). Cell Cycle. 4:1350–1352. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Brabletz T, Hlubek F, Spaderna S, Schmalhofer O, Hiendlmeyer E, Jung A and Kirchner T: Invasion and metastasis in colorectal cancer: Epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin. Cells Tissues Organs. 179:56–65. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Arias AM: Epithelial mesenchymal interactions in cancer and development. Cell. 105:425–431. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Polyak K and Weinberg RA: Transitions between epithelial and mesenchymal state: Acquisition of malignant and stem cell traits. Nat Rev Cancer. 9:265–273. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Wijnhoven BP, Dinjens WN and Pignatelli M: E-cadherin-catenin cell-cell adhesion complex and human cancer. Br J Surg. 87:992–1005. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Zlobec I, Lugli A, Baker K, Roth S, Minoo P, Hayashi S, Terracciano L and Jass JR: Role of APAF-1, E-cadherin and peritumoral lymphocytic infiltration in tumour budding in colorectal cancer. J Pathol. 212:260–268. 2007. View Article : Google Scholar : PubMed/NCBI

34 

He X, Chen Z, Jia M and Zhao X: Downregulated E-cadherin expression indicates worse prognosis in Asian patients with colorectal cancer: Evidence from meta-analysis. PLoS One. 8:e708582013. View Article : Google Scholar : PubMed/NCBI

35 

Sleeman J, Kondo K, Moll J, Ponta H and Herrlich P: Variant exon v6 and v7 together expand the repertoire of glycolsaminoglycans bound by CD44. J Biol Chem. 272:31837–31844. 1997. View Article : Google Scholar : PubMed/NCBI

36 

Yang AD, Fan F, Camp ER, van Buren G, Liu W, Somcio R, Gray MJ, Cheng H, Hoff PM and Ellis LM: Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines. Clin Cancer Res. 12:4147–4153. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Mulder JW, Kruyt PM, Sewnath M, Oosting J, Seldenrijk CA, Weidema WF, Offerhaus GJ and Pals ST: Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins. Lancet. 344:1470–1472. 1994. View Article : Google Scholar : PubMed/NCBI

38 

Morrin M and Delaney PV: CD44v6 is not relevant in colorectal tumour progression. Int J Colorectal Dis. 17:30–36. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Stanczak A, Stec R, Bodnar L, Olszewski W, Cichowicz M, Kozlowski W, Szczylik C, Pietrucha T, Wieczorek M and Lamparska-Przybysz M: Prognostic significance of Wnt-1, β-catenin and E-cadherin expression in advanced colorectal carcinoma. Pathol Oncol Res. 17:955–963. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Ilyas M, Novelli M, Wilkinson K, Tomlinson IP, Abbasi AM, Forbes A and Talbot IC: Tumour recurrence is associated with Jass grouping but not with differences in E-cadherin expression in moderately differentiated Dukes' B colorectal cancers. J Clin Pathol. 50:218–222. 1997. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Iseki Y, Shibutani M, Maeda K, Nagahara H, Ikeya T and Hirakawa K: Significance of E-cadherin and CD44 expression in patients with unresectable metastatic colorectal cancer. Oncol Lett 14: 1025-1034, 2017.
APA
Iseki, Y., Shibutani, M., Maeda, K., Nagahara, H., Ikeya, T., & Hirakawa, K. (2017). Significance of E-cadherin and CD44 expression in patients with unresectable metastatic colorectal cancer. Oncology Letters, 14, 1025-1034. https://doi.org/10.3892/ol.2017.6269
MLA
Iseki, Y., Shibutani, M., Maeda, K., Nagahara, H., Ikeya, T., Hirakawa, K."Significance of E-cadherin and CD44 expression in patients with unresectable metastatic colorectal cancer". Oncology Letters 14.1 (2017): 1025-1034.
Chicago
Iseki, Y., Shibutani, M., Maeda, K., Nagahara, H., Ikeya, T., Hirakawa, K."Significance of E-cadherin and CD44 expression in patients with unresectable metastatic colorectal cancer". Oncology Letters 14, no. 1 (2017): 1025-1034. https://doi.org/10.3892/ol.2017.6269
Copy and paste a formatted citation
x
Spandidos Publications style
Iseki Y, Shibutani M, Maeda K, Nagahara H, Ikeya T and Hirakawa K: Significance of E-cadherin and CD44 expression in patients with unresectable metastatic colorectal cancer. Oncol Lett 14: 1025-1034, 2017.
APA
Iseki, Y., Shibutani, M., Maeda, K., Nagahara, H., Ikeya, T., & Hirakawa, K. (2017). Significance of E-cadherin and CD44 expression in patients with unresectable metastatic colorectal cancer. Oncology Letters, 14, 1025-1034. https://doi.org/10.3892/ol.2017.6269
MLA
Iseki, Y., Shibutani, M., Maeda, K., Nagahara, H., Ikeya, T., Hirakawa, K."Significance of E-cadherin and CD44 expression in patients with unresectable metastatic colorectal cancer". Oncology Letters 14.1 (2017): 1025-1034.
Chicago
Iseki, Y., Shibutani, M., Maeda, K., Nagahara, H., Ikeya, T., Hirakawa, K."Significance of E-cadherin and CD44 expression in patients with unresectable metastatic colorectal cancer". Oncology Letters 14, no. 1 (2017): 1025-1034. https://doi.org/10.3892/ol.2017.6269
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