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Frequent aberrant p53 and Fhit expression in endoscopically resected superficial hypopharyngeal cancer and esophageal cancer

  • Authors:
    • Sohei Yamamoto
    • Kazuo Yashima
    • Soichiro Kawata
    • Kohei Hosoda
    • Akihiro Tamoto
    • Yuichiro Ikebuchi
    • Kazuya Matsumoto
    • Koichiro Kawaguchi
    • Kenichi Harada
    • Yoshikazu Murawaki
    • Hajime Isomoto
  • View Affiliations / Copyright

    Affiliations: Division of Medicine and Clinical Science, Faculty of Medicine, University of Tottori, Yonago 683‑8504, Japan
    Copyright: © Yamamoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 587-592
    |
    Published online on: May 29, 2017
       https://doi.org/10.3892/ol.2017.6271
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Abstract

In the last decade, the incidence rate of detection rate of superficial head, neck and esophageal squamous cell carcinomas has increased with the development of endoscopic imaging techniques. These cancers are thought to arise independently subsequent to tissue exposure to a common carcinogen e.g. alcohol or tobacco. This phenomenon has been termed field cancerization. To determine the molecular background of the development of hypopharyngeal squamous cell carcinomas (HPSCCs) and double esophageal squamous cell carcinomas (DESCCs), the present study immunohistochemically assessed tumor‑related protein expression [p53, Fhit (fragile histidine triad), E‑cadherin and activation‑induced cytidine deaminase (AID)], and subsequently determined the correlation between protein expression and clinicopathological data. Tumor specimens of 9 HPSCCs and 9 DESCCs were endoscopically obtained from 8 patients with HPSCC. The 9 DESCCs, including 5 synchronous and 4 metachronous lesions, were all obtained from four patients with HPSCC. The overexpression of p53 and loss of Fhit expression was immunohistochemically detected in 8 (88.9%) and 8 (88.9%) of the 9 HPSCCs and in 8 (88.9%) and 8 (88.9%) of the 9 DESCCs, respectively, which demonstrated the high frequency of such expression. Additionally, 7 out of 9 HPSCCs, and 7 out of 9 DESCCs demonstrated aberrant expression of p53 and Fhit. The rate of aberrant AID and E‑cadherin expression was 67 and 44% in HPSCCs and 44 and 44% in DESCC, respectively. These results suggested that aberrant p53 and Fhit expression was involved in the development of HPSCC and their DESCC, and that their expression may be used for the prediction of DESCC development in patients with HPSCC, thereby acting as a biomarker of field cancerization.
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1 

Perez-Ordoñez B, Beauchemin M and Jordan RC: Molecular biology of squamous cell carcinoma of the head and neck. J Clin Pathol. 59:445–453. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Toh Y, Oki E, Ohgaki K, Sakamoto Y, Ito S, Egashira A, Saeki H, Kakeji Y, Morita M, Sakaguchi Y, et al: Alcohol drinking, cigarette smoking, and development of squamous cell carcinoma of the esophagus: Molecular mechanisms of carcinogenesis. Inc J Clin Oncol. 15:135–144. 2010. View Article : Google Scholar

3 

Slaughter DP, Southwick HW and Smejkal W: Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer. 6:963–968. 1953. View Article : Google Scholar : PubMed/NCBI

4 

Ina H, Shibuya H, Ohashi I and Kitagawa M: The frequency of a concomitant early esophageal cancer in male patients with oral and oropharyngeal cancer. Screening results using Lugol dye endoscopy. Cancer. 73:2038–2041. 1994. View Article : Google Scholar : PubMed/NCBI

5 

Dubuc J, Legoux J..Winnock M, Seyrig J..Barbier J..Barrioz T, Laugier R, Boulay G, Grasset D, Sautereau D, et al: Endoscopic screening for esophageal squamous cell carcinoma in high-risk patients: A prospective study conducted in 62 French endoscopy centers. Endoscopy. 57:690–695. 2006. View Article : Google Scholar

6 

Goda K, Dobashi A and Tajiri H: Perspectives on narrow-band imaging endoscopy for superficial squamous neoplasms of the orohypopharynx and esophagus. Dig Endosc. 26 Suppl 1:S1–S11. 2014. View Article : Google Scholar

7 

Shimizu Y, Yamamoto J, Kato M, Yoshida T, Hirota J, Ono Y, Nakagawa M, Nakagawa S, Oridate N and Asaka M: Endoscopic submucosal dissection for treatment of early stage hypopharyngeal carcinoma. Gastrointest Endosc. 64:255–262. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Hanaoka N, Ishihara R, Takeuchi Y, Suzuki M, Otozai S, Kida K, Yoshii T, Fujii T, Yoshino K, Sugawa T, et al: Endoscopic submucosal dissection as minimally invasive treatment for superficial pharyngeal cancer: A phase II study (with video). Gastrointest Endosc. 82:1002–1008. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Mattijssen V, Peters HM, Schalkwijk L, Manni JJ, van't Hof-Grootenboer B, de Mulder PH and Ruiter DJ: E-cadherin expression in head and neck squamous-cell carcinoma is associated with clinical outcome. Int J Cancer. 55:580–585. 1993. View Article : Google Scholar : PubMed/NCBI

10 

Xu XC: Risk factors and gene expression in esophageal cancer. Methods Mol Biol. 471:335–360. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y and Honjo T: Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell. 102:553–563. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Matsumoto Y, Marusawa H, Kinoshita K, Endo Y, Kou T, Morisawa T, Azuma T, Okazaki IM, Honjo T and Chiba T: Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat Med. 13:470–476. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Hollestein M, Sidransky D, Vogelstein B and Harris CC: p53 mutations in human cancers. Science. 253:49–53. 1991. View Article : Google Scholar : PubMed/NCBI

14 

Ohta M, Inoue H, Cotticelli MG, Kastury K, Baffa R, Palazzo J, Siprashvili Z, Mori M, McCue P, Druck T, et al: The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancer. Cell. 84:587–597. 1996. View Article : Google Scholar : PubMed/NCBI

15 

Mori M, Mimori K, Shiraishi T, Alder H, Inoue H, Tanaka Y, Sugimachi K, Huebner K and Croce CM: Altered expression of Fhit in carcinoma precarcinomatous lesions of the esophagus. Cancer Res. 60:1177–1182. 2000.PubMed/NCBI

16 

Lee EJ, Lee BB, Kim JW, Shim YM, Hoseok I, Han J, Cho EY, Park J and Kim DH: Aberrant methylation of Fragile Histidine Triad gene is associated with poor prognosis in early stage esophageal squamous cell carcinoma. Eur J Cancer. 42:972–980. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Soma T, Kaganoi J, Kawabe A, Kondo K, Imamura M and Shimada Y: Nicotine induces the fragile histidine triad methylation in human esophageal squamous epithelial cells. Int J Cancer. 119:1023–1027. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Morita M, Oyama T, Nakata S, Ono K, Sugaya M, Uramoto H, Yoshimatsu T, Hanagiri T, Sugio K and Yasumoto K: Expression of FHIT in esophageal epithelium and carcinoma: Reference to drinking, smoking and multicentric carcinogenesis. Anticancer Res. 26:2243–2248. 2006.PubMed/NCBI

19 

Ishii H, Dumon KR, Vecchione A, Trapasso F, Mimori K, Alder H, Mori M, Sozzi G, Baffa R, Huebner K and Croce CM: Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells. Cancer Res. 61:1578–1584. 2001.PubMed/NCBI

20 

Tamura S, Shiozaki H, Miyata M, Kadowaki T, Inoue M, Matsui S, Iwazawa T, Takayama T, Takeichi M and Monden M: Decreased E-cadherin expression is associated with haematogenous recurrence and poor prognosis in patients with squamous cell carcinoma of the oesophagus. Br J Surg. 83:1608–1614. 1996. View Article : Google Scholar : PubMed/NCBI

21 

Hirohashi S: Inactivation of the E-cadherin-mediated cell adhesion system in human cancers. Am J Pathol. 153:333–339. 1998. View Article : Google Scholar : PubMed/NCBI

22 

Warren S and Gates O: Multiple primary, malignant tumors: A survey of the literature and statistical study. Am J Cancer. 16:1358–1414. 1932.

23 

Brooks PJ, Enoch MA, Goldman D, Li TK and Yokoyama A: The alcohol flushing response: An unrecognized risk factor for esophageal cancer from alcohol consumption. PLoS Med. 6:e502009. View Article : Google Scholar : PubMed/NCBI

24 

Saldivar JC, Shibata H and Huebner K: Pathology and biology associated with the fragile FHIT gene and gene product. J Cell Biochem. 109:858–865. 2010.PubMed/NCBI

25 

Yokoyama A, Mizukami T and Yokoyama T: Genetic polymorphisms of alcohol dehydrogense-1B and aldehyde dehydrogenase-2, alcohol flushing, mean corpuscular volume, and aerodigestive tract neoplasia in Japanese drinkers. Adv Exp Med Biol. 815:265–279. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Sauter ER, Cleveland D, Trock B, Ridge JA and Klein-Szanto AJ: p53 is overexpressed in fifty percent of pre-invasive lesions of head and neck epithelium. Carcinogenesis. 15:2269–2274. 1994. View Article : Google Scholar : PubMed/NCBI

27 

Hayashi A, Yashima K, Takeda Y, Sasaki S, Kawaguchi K, Harada K, Murawaki Y and Ito H: Fhit, E-cadherin, p53, and activation-induced cytidine deaminase expression in endoscopically resected early stage esophageal squamous neoplasia. J Gastroenterol Hepatol. 27:1752–1758. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Kohmura T, Hasegawa Y, Ogawa T, Matsuura H, Takahashi M, Yanagita N and Nakashima T: Cyclin D1 and p53 overexpression predicts multiple primary malignant neoplasms of the hypopharynx and esophagus. Arch Otolaryngol Head Neck Surg. 125:1351–1354. 1999. View Article : Google Scholar : PubMed/NCBI

29 

Kato H, Yoshikawa M, Miyazaki T, Nakajima M, Fukai Y, Tajima K, Masuda N, Tsukada K, Fukuda T, Nakajima T and Kuwano H: Expression of p53 protein related to smoking and alcoholic beverage drinking habits in patients with esophageal cancers. Cancer Lett. 167:65–72. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Chung Y, Lam AK, Luk JM, Law S, Chan KW, Lee PY and Wong J: Altered E-cadherin expression and p120 catenin localization in esophageal squamous cell carcinoma. Ann Surg Oncol. 14:3260–3267. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Miyazaki Y, Fujinami M, Inoue H, Kikuchi K, Ide F and Kusama K: Expression of activation-induced cytidine deaminase in oral epithelial dysplasia and oral squamous cell carcinoma. J Oral Sci. 55:293–299. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Nakanishi Y, Kondo S, Wakisaka N, Tsuji A, Endo K, Murono S, Ito M, Kitamura K, Muramatsu M and Yoshizaki T: Role of activation-induced cytidine deaminase in the development of oral squamous cell carcinoma. PLoS One. 8:e620662013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yamamoto S, Yashima K, Kawata S, Hosoda K, Tamoto A, Ikebuchi Y, Matsumoto K, Kawaguchi K, Harada K, Murawaki Y, Murawaki Y, et al: Frequent aberrant p53 and Fhit expression in endoscopically resected superficial hypopharyngeal cancer and esophageal cancer. Oncol Lett 14: 587-592, 2017.
APA
Yamamoto, S., Yashima, K., Kawata, S., Hosoda, K., Tamoto, A., Ikebuchi, Y. ... Isomoto, H. (2017). Frequent aberrant p53 and Fhit expression in endoscopically resected superficial hypopharyngeal cancer and esophageal cancer. Oncology Letters, 14, 587-592. https://doi.org/10.3892/ol.2017.6271
MLA
Yamamoto, S., Yashima, K., Kawata, S., Hosoda, K., Tamoto, A., Ikebuchi, Y., Matsumoto, K., Kawaguchi, K., Harada, K., Murawaki, Y., Isomoto, H."Frequent aberrant p53 and Fhit expression in endoscopically resected superficial hypopharyngeal cancer and esophageal cancer". Oncology Letters 14.1 (2017): 587-592.
Chicago
Yamamoto, S., Yashima, K., Kawata, S., Hosoda, K., Tamoto, A., Ikebuchi, Y., Matsumoto, K., Kawaguchi, K., Harada, K., Murawaki, Y., Isomoto, H."Frequent aberrant p53 and Fhit expression in endoscopically resected superficial hypopharyngeal cancer and esophageal cancer". Oncology Letters 14, no. 1 (2017): 587-592. https://doi.org/10.3892/ol.2017.6271
Copy and paste a formatted citation
x
Spandidos Publications style
Yamamoto S, Yashima K, Kawata S, Hosoda K, Tamoto A, Ikebuchi Y, Matsumoto K, Kawaguchi K, Harada K, Murawaki Y, Murawaki Y, et al: Frequent aberrant p53 and Fhit expression in endoscopically resected superficial hypopharyngeal cancer and esophageal cancer. Oncol Lett 14: 587-592, 2017.
APA
Yamamoto, S., Yashima, K., Kawata, S., Hosoda, K., Tamoto, A., Ikebuchi, Y. ... Isomoto, H. (2017). Frequent aberrant p53 and Fhit expression in endoscopically resected superficial hypopharyngeal cancer and esophageal cancer. Oncology Letters, 14, 587-592. https://doi.org/10.3892/ol.2017.6271
MLA
Yamamoto, S., Yashima, K., Kawata, S., Hosoda, K., Tamoto, A., Ikebuchi, Y., Matsumoto, K., Kawaguchi, K., Harada, K., Murawaki, Y., Isomoto, H."Frequent aberrant p53 and Fhit expression in endoscopically resected superficial hypopharyngeal cancer and esophageal cancer". Oncology Letters 14.1 (2017): 587-592.
Chicago
Yamamoto, S., Yashima, K., Kawata, S., Hosoda, K., Tamoto, A., Ikebuchi, Y., Matsumoto, K., Kawaguchi, K., Harada, K., Murawaki, Y., Isomoto, H."Frequent aberrant p53 and Fhit expression in endoscopically resected superficial hypopharyngeal cancer and esophageal cancer". Oncology Letters 14, no. 1 (2017): 587-592. https://doi.org/10.3892/ol.2017.6271
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