Mutation of the TERT promoter leads to poor prognosis of patients with non‑small cell lung cancer

  • Authors:
    • Soo‑Jung Jung
    • Dong‑Sun Kim
    • Won‑Jin Park
    • Hyunsu Lee
    • In‑Jang Choi
    • Jae‑Yong Park
    • Jae‑Ho Lee
  • View Affiliations

  • Published online on: May 31, 2017     https://doi.org/10.3892/ol.2017.6284
  • Pages: 1609-1614
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Abstract

Mutations in the promoter region of telomerase reverse transcriptase (TERT) and alterations in telomere length (TL) have been the focus of research in various types of cancer. In the present study, the frequency and clinical characteristics of TERT promoter mutations and TL were studied in non‑small cell lung cancers (NSCLC). TERT promoter mutations and TL were analyzed in 188 patients using DNA sequencing and the reverse transcription‑quantitative polymerase chain reaction, respectively. The TERT promoter mutation rate was observed to be 2.2% (4/188 NSCLC cases), and it was significantly associated with regional lymph node invasion (P<0.001). No significant difference in TL was observed between the patients with and without TERT promoter mutations. TL was decreased in males (P=0.058 vs. females) and smokers (P=0.008 vs. non‑smokers). Survival analyses demonstrated poor prognoses for patients with NSCLC with TERT promoter mutations (P<0.001). Multivariate survival analyses demonstrated that TERT promoter mutations were an independent prognostic marker for poor overall survival (P=0.045). The results of the present study demonstrated that TERT promoter mutation was not frequent in NSCLC; however, it may have value as a prognostic marker in NSCLC.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Jung SJ, Kim DS, Park WJ, Lee H, Choi IJ, Park JY and Lee JH: Mutation of the TERT promoter leads to poor prognosis of patients with non‑small cell lung cancer. Oncol Lett 14: 1609-1614, 2017
APA
Jung, S., Kim, D., Park, W., Lee, H., Choi, I., Park, J., & Lee, J. (2017). Mutation of the TERT promoter leads to poor prognosis of patients with non‑small cell lung cancer. Oncology Letters, 14, 1609-1614. https://doi.org/10.3892/ol.2017.6284
MLA
Jung, S., Kim, D., Park, W., Lee, H., Choi, I., Park, J., Lee, J."Mutation of the TERT promoter leads to poor prognosis of patients with non‑small cell lung cancer". Oncology Letters 14.2 (2017): 1609-1614.
Chicago
Jung, S., Kim, D., Park, W., Lee, H., Choi, I., Park, J., Lee, J."Mutation of the TERT promoter leads to poor prognosis of patients with non‑small cell lung cancer". Oncology Letters 14, no. 2 (2017): 1609-1614. https://doi.org/10.3892/ol.2017.6284