Open Access

α‑taxilin overexpression correlates with proliferation activity but not with prognosis of colorectal cancer

  • Authors:
    • Akira Kanamori
    • Yasuo Imai
    • Keisuke Ihara
    • Hitoshi Nagata
    • Masakazu Nakano
    • Keiichi Tominaga
    • Hiroaki Shimizu
    • Tomihiko Makiyama
    • Hajime Kuroda
    • Hiromichi Shirataki
    • Hideyuki Hiraishi
  • View Affiliations

  • Published online on: June 2, 2017     https://doi.org/10.3892/ol.2017.6309
  • Pages: 1471-1476
  • Copyright: © Kanamori et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

α‑taxilin is a binding partner of syntaxins, which are the central coordinators of membrane traffic. Expression of α‑taxilin has been implicated in the development of human glioblastoma, hepatocellular carcinoma and renal cell carcinoma. In the present study, the clinical significance of α‑taxilin expression in colorectal cancer (CRC) was investigated. A total of 20 cases of colorectal intramucosal adenocarcinoma (IMA) with adenoma were analyzed using immunohistochemical analysis. The results demonstrated that α‑taxilin expression was significantly associated with Ki‑67 indices in adenoma and IMA. The patients expressed equally high levels of α‑taxilin in the upper third of the intramucosal glands. These results suggest that α‑taxilin expression is significantly associated with the proliferative activity of CRC, but that its overexpression alone is not a biomarker of malignancy. Next, α‑taxilin expression was investigated in 57 advanced CRCs and its association with prognosis was determined. Well‑differentiated and/or moderately differentiated adenocarcinomas in the left‑sided colon with anatomic stage II and/or III were analyzed. α‑taxilin expression levels were high on the surface of nearly all tumors, but variable at the deep advancing edge. α‑taxilin levels at the advancing edge were not significantly associated with local invasiveness or prognosis. In conclusion, α‑taxilin is a cell proliferation marker in colorectal epithelial neoplasms but cannot be a marker of malignancy or prognosis of CRCs.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Kanamori A, Imai Y, Ihara K, Nagata H, Nakano M, Tominaga K, Shimizu H, Makiyama T, Kuroda H, Shirataki H, Shirataki H, et al: α‑taxilin overexpression correlates with proliferation activity but not with prognosis of colorectal cancer. Oncol Lett 14: 1471-1476, 2017
APA
Kanamori, A., Imai, Y., Ihara, K., Nagata, H., Nakano, M., Tominaga, K. ... Hiraishi, H. (2017). α‑taxilin overexpression correlates with proliferation activity but not with prognosis of colorectal cancer. Oncology Letters, 14, 1471-1476. https://doi.org/10.3892/ol.2017.6309
MLA
Kanamori, A., Imai, Y., Ihara, K., Nagata, H., Nakano, M., Tominaga, K., Shimizu, H., Makiyama, T., Kuroda, H., Shirataki, H., Hiraishi, H."α‑taxilin overexpression correlates with proliferation activity but not with prognosis of colorectal cancer". Oncology Letters 14.2 (2017): 1471-1476.
Chicago
Kanamori, A., Imai, Y., Ihara, K., Nagata, H., Nakano, M., Tominaga, K., Shimizu, H., Makiyama, T., Kuroda, H., Shirataki, H., Hiraishi, H."α‑taxilin overexpression correlates with proliferation activity but not with prognosis of colorectal cancer". Oncology Letters 14, no. 2 (2017): 1471-1476. https://doi.org/10.3892/ol.2017.6309