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Article Open Access

Long non-coding RNA expression profile in cervical cancer tissues

  • Authors:
    • Hua Zhu
    • Xiangjian Chen
    • Yan Hu
    • Zhengzheng Shi
    • Qing Zhou
    • Jingjie Zheng
    • Yifeng Wang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China, Department of Endoscopic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1379-1386
    |
    Published online on: June 6, 2017
       https://doi.org/10.3892/ol.2017.6319
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Abstract

Cervical cancer (CC), one of the most common types of cancer of the female population, presents an enormous challenge in diagnosis and treatment. Long non‑coding (lnc)RNAs, non‑coding (nc)RNAs with length >200 nucleotides, have been identified to be associated with multiple types of cancer, including CC. This class of nc transcripts serves an important role in tumor suppression and oncogenic signaling pathways. In the present study, the microarray method was used to obtain the expression profile of lncRNAs and protein‑coding mRNAs and to compare the expression of lncRNAs between CC tissues and corresponding adjacent non‑cancerous tissues in order to screen potential lncRNAs for associations with CC. Overall, 3356 lncRNAs with significantly different expression pattern in CC tissues compared with adjacent non‑cancerous tissues were identified, while 1,857 of them were upregulated. These differentially expressed lncRNAs were additionally classified into 5 subgroups. Reverse transcription quantitative polymerase chain reactions were performed to validate the expression pattern of 5 random selected lncRNAs, and 2lncRNAs were identified to have significantly different expression in CC samples compared with adjacent non‑cancerous tissues. This finding suggests that those lncRNAs with different expression may serve important roles in the development of CC, and the expression data may provide information for additional study on the involvement of lncRNAs in CC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu H, Chen X, Hu Y, Shi Z, Zhou Q, Zheng J and Wang Y: Long non-coding RNA expression profile in cervical cancer tissues. Oncol Lett 14: 1379-1386, 2017.
APA
Zhu, H., Chen, X., Hu, Y., Shi, Z., Zhou, Q., Zheng, J., & Wang, Y. (2017). Long non-coding RNA expression profile in cervical cancer tissues. Oncology Letters, 14, 1379-1386. https://doi.org/10.3892/ol.2017.6319
MLA
Zhu, H., Chen, X., Hu, Y., Shi, Z., Zhou, Q., Zheng, J., Wang, Y."Long non-coding RNA expression profile in cervical cancer tissues". Oncology Letters 14.2 (2017): 1379-1386.
Chicago
Zhu, H., Chen, X., Hu, Y., Shi, Z., Zhou, Q., Zheng, J., Wang, Y."Long non-coding RNA expression profile in cervical cancer tissues". Oncology Letters 14, no. 2 (2017): 1379-1386. https://doi.org/10.3892/ol.2017.6319
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu H, Chen X, Hu Y, Shi Z, Zhou Q, Zheng J and Wang Y: Long non-coding RNA expression profile in cervical cancer tissues. Oncol Lett 14: 1379-1386, 2017.
APA
Zhu, H., Chen, X., Hu, Y., Shi, Z., Zhou, Q., Zheng, J., & Wang, Y. (2017). Long non-coding RNA expression profile in cervical cancer tissues. Oncology Letters, 14, 1379-1386. https://doi.org/10.3892/ol.2017.6319
MLA
Zhu, H., Chen, X., Hu, Y., Shi, Z., Zhou, Q., Zheng, J., Wang, Y."Long non-coding RNA expression profile in cervical cancer tissues". Oncology Letters 14.2 (2017): 1379-1386.
Chicago
Zhu, H., Chen, X., Hu, Y., Shi, Z., Zhou, Q., Zheng, J., Wang, Y."Long non-coding RNA expression profile in cervical cancer tissues". Oncology Letters 14, no. 2 (2017): 1379-1386. https://doi.org/10.3892/ol.2017.6319
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