1
|
Derynck R and Akhurst RJ: Differentiation
plasticity regulated by TGF-beta family proteins in development and
disease. Nat Cell Biol. 9:1000–1004. 2007. View Article : Google Scholar : PubMed/NCBI
|
2
|
Chen YG: Endocytic regulation of TGF-beta
signaling. Cell Res. 19:58–70. 2009. View Article : Google Scholar : PubMed/NCBI
|
3
|
Moustakas A and Heldin CH: Non-Smad
TGF-beta signals. J Cell Sci. 118:3573–3584. 2005. View Article : Google Scholar : PubMed/NCBI
|
4
|
Bell LA and Ryan KM: Life and death
decisions by E2F-1. Cell Death Differ. 11:137–142. 2004. View Article : Google Scholar : PubMed/NCBI
|
5
|
Field SJ, Tsai FY, Kuo F, Zubiaga AM,
Kaelin WG Jr, Livingston DM, Orkin SH and Greenberg ME: E2F-1
functions in mice to promote apoptosis and suppress proliferation.
Cell. 85:549–561. 1996. View Article : Google Scholar : PubMed/NCBI
|
6
|
Dyson N: The regulation of E2F by
pRB-family proteins. Genes Dev. 12:2245–2262. 1998. View Article : Google Scholar : PubMed/NCBI
|
7
|
Sherr CJ and McCormick F: The RB and p53
pathways in cancer. Cancer Cell. 2:103–112. 2002. View Article : Google Scholar : PubMed/NCBI
|
8
|
Pardali K and Moustakas A: Actions of
TGF-beta as tumor suppressor and pro-metastatic factor in human
cancer. Biochim Biophys Acta. 1775:21–62. 2007.PubMed/NCBI
|
9
|
Siegel PM and Massagué J: Cytostatic and
apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev
Cancer. 3:807–821. 2003. View
Article : Google Scholar : PubMed/NCBI
|
10
|
Chen CR, Kang Y and Massagué J: Defective
repression of c-myc in breast cancer cells: A loss at the core of
the transforming growth factor beta growth arrest program. Proc
Natl Acad Sci USA. 98:pp. 992–999. 2001; View Article : Google Scholar : PubMed/NCBI
|
11
|
Warner BJ, Blain SW, Seoane J and Massagué
J: Myc downregulation by transforming growth factor beta required
for activation of the p15(Ink4b) G(1) arrest pathway. Mol Cell
Biol. 19:5913–5922. 1999. View Article : Google Scholar : PubMed/NCBI
|
12
|
Iavarone A and Massagué J: Repression of
the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta
in cells lacking the CDK inhibitor p15. Nature. 387:417–422. 1997.
View Article : Google Scholar : PubMed/NCBI
|
13
|
Baughn LB, Di Liberto M, Niesvizky R, Cho
HJ, Jayabalan D, Lane J, Liu F and Chen-Kiang S: CDK2
phosphorylation of Smad2 disrupts TGF-beta transcriptional
regulation in resistant primary bone marrow myeloma cells. J
Immunol. 182:1810–1817. 2009. View Article : Google Scholar : PubMed/NCBI
|
14
|
Molina-Privado I, Rodríguez-Martínez M,
Rebollo P, Martín-Pérez D, Artiga MJ, Menárguez J, Flemington EK,
Piris MA and Campanero MR: E2F1 expression is deregulated and plays
an oncogenic role in sporadic Burkitt's lymphoma. Cancer Res.
69:4052–4058. 2009. View Article : Google Scholar : PubMed/NCBI
|
15
|
Hallstrom TC, Mori S and Nevins JR: An
E2F1-dependent gene expression program that determines the balance
between proliferation and cell death. Cancer Cell. 13:11–22. 2008.
View Article : Google Scholar : PubMed/NCBI
|
16
|
Sun B, Wingate H, Swisher SG, Keyomarsi K
and Hunt KK: Absence of pRb facilitates E2F1-induced apoptosis in
breast cancer cells. Cell Cycle. 9:1122–1130. 2010. View Article : Google Scholar : PubMed/NCBI
|
17
|
Schwarz JK, Bassing CH, Kovesdi I, Datto
MB, Blazing M, George S, Wang XF and Nevins JR: Expression of the
E2F1 transcription factor overcomes type beta transforming growth
factor-mediated growth suppression. Proc Natl Acad Sci USA. 92:pp.
483–487. 1995; View Article : Google Scholar : PubMed/NCBI
|
18
|
Chellappan SP, Hiebert S, Mudryj M,
Horowitz JM and Nevins JR: The E2F transcription factor is a
cellular target for the RB protein. Cell. 65:1053–1061. 1991.
View Article : Google Scholar : PubMed/NCBI
|
19
|
Mohammad KS, Chen CG, Balooch G, Stebbins
E, McKenna CR, Davis H, Niewolna M, Peng XH, Nguyen DH,
Ionova-Martin SS, et al: Pharmacologic inhibition of the TGF-beta
type I receptor kinase has anabolic and anti-catabolic effects on
bone. PLoS One. 4:e52752009. View Article : Google Scholar : PubMed/NCBI
|
20
|
Matsumoto T and Abe M: TGF-β-related
mechanisms of bone destruction in multiple myeloma. Bone.
48:129–134. 2001. View Article : Google Scholar
|
21
|
Hayashi H, Abdollah S, Qiu Y, Cai J, Xu
YY, Grinnell BW, Richardson MA, Topper JN, Gimbrone MA Jr, Wrana JL
and Falb D: The MAD-related protein Smad7 associates with the
TGFbeta receptor and functions as an antagonist of TGFbeta
signaling. Cell. 89:1165–1173. 1997. View Article : Google Scholar : PubMed/NCBI
|
22
|
Hata A, Lagna G, Massagué J and
Hemmati-Brivanlou A: Smad6 inhibits BMP/Smad1 signaling by
specifically competing with the Smad4 tumor suppressor. Genes Dev.
12:186–197. 1998. View Article : Google Scholar : PubMed/NCBI
|
23
|
Bakin AV, Rinehart C, Tomlinson AK and
Arteaga CL: p38 mitogen-activated protein kinase is required for
TGFbeta-mediated fibroblastic transdifferentiation and cell
migration. J Cell Sci. 115:3193–3206. 2002.PubMed/NCBI
|
24
|
Bakin AV, Tomlinson AK, Bhowmick NA, Moses
HL and Arteaga CL: Phosphatidylinositol 3-kinase function is
required for transforming growth factor beta-mediated epithelial to
mesenchymal transition and cell migration. J Biol Chem.
275:36803–36810. 2000. View Article : Google Scholar : PubMed/NCBI
|
25
|
Bhowmick NA, Ghiassi M, Bakin A, Aakre M,
Lundquist CA, Engel ME, Arteaga CL and Moses HL: Transforming
growth factor-beta1 mediates epithelial to mesenchymal
transdifferentiationthrough a RhoA-dependent mechanism. Mol Biol
Cell. 12:27–36. 2001. View Article : Google Scholar : PubMed/NCBI
|
26
|
Siegel PM and Massagué J: Cytostatic and
apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev
Cancer. 3:807–821. 2003. View
Article : Google Scholar : PubMed/NCBI
|
27
|
Spender LC and Inman GJ: TGF-beta induces
growth arrest in Burkitt lymphoma cells via transcriptional
repression of E2F-1. J Biol Chem. 284:1435–1442. 2009. View Article : Google Scholar : PubMed/NCBI
|
28
|
Korah J, Falah N, Lacerte A and Lebrun JJ:
A transcriptionally active pRb-E2F1-P/CAF signaling pathway is
central to TGFβ-mediated apoptosis. Cell Death Dis. 3:e4072012.
View Article : Google Scholar : PubMed/NCBI
|