Ceramide synthase-4 orchestrates the cell proliferation and tumor growth of liver cancer in vitro and in vivo through the nuclear factor-κB signaling pathway Corrigendum in /10.3892/ol.2021.12551

Chen,Jinwu; Li,Xiaojie; Ma,Dengjiao; Liu,Tao; Tian,Pingping; Wu,Chuanfang

doi:10.3892/ol.2017.6365

August-2017 Volume 14 Issue 2

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August-2017 Volume 14 Issue 2

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Ceramide synthase-4 orchestrates the cell proliferation and tumor growth of liver cancer in vitro and in vivo through the nuclear factor-κB signaling pathway

Corrigendum in: /10.3892/ol.2021.12551

Authors:
- Jinwu Chen
- Xiaojie Li
- Dengjiao Ma
- Tao Liu
- Pingping Tian
- Chuanfang Wu
View Affiliations / Copyright

Affiliations: School of Life Sciences and Key Laboratory of Bio‑Resources and Eco‑Environment, Sichuan University, Ministry of Education, Chengdu, Sichuan 610064, P.R. China

Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 1477-1483
|
Published online on: June 9, 2017

https://doi.org/10.3892/ol.2017.6365
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Abstract

Liver cancer is one of the leading causes of cancer-associated mortalities worldwide, partly due to the absence of effective therapeutic targets and diagnostic biomarkers. Therefore, novel molecular targets are critical to develop new therapeutic approaches for liver cancer. In the present study, ceramide synthase‑4 (CERS4) was investigated as a novel molecular target for liver cancer. High expression of CERS4 in liver cancer tissues was detected by reverse transcription polymerase chain reaction and western blot analysis. Subsequently, CERS4 was silenced by lentivirus‑mediated RNA interfere, and the proliferation rates of liver cancer cells were significantly suppressed (P<0.001). In addition, the weight and volume of the tumors were reduced subsequent to silencing of CERS4 in liver cancer cells, revealed by an in vivo study using Balb/c nude mice. In addition, the nuclear factor (NF)‑κB signaling pathway was affected following knockdown of CERS4 in liver cancer cells. The present results proposed that CERS4 is an important regulator of liver cancer cell proliferation and indicated that CERS4 may be a potential anticancer therapeutic target and a promising diagnostic biomarker for human liver cancer.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Ceramide synthase-4 orchestrates the cell proliferation and tumor growth of liver cancer in vitro and in vivo through the nuclear factor-κB signaling pathway

Corrigendum in: /10.3892/ol.2021.12551

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Abstract

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