Open Access

Understanding the role of CD44V6 in ovarian cancer

  • Authors:
    • Hui-Feng Zhang
    • Peng Hu
    • Sheng-Quan Fang
  • View Affiliations

  • Published online on: June 13, 2017     https://doi.org/10.3892/ol.2017.6377
  • Pages: 1989-1992
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

This study examined the association of CD44V6 expression in ovarian cancer. We recruited 38 patients with ovarian cancer, 23 with benign ovarian tumor, and 20 with normal ovaries using RT-PCR and western block analysis. Compared with normal ovaries, the expression of CD44V6 mRNA was significantly elevated in benign ovarian tumor and ovarian cancer. At the protein level, we found no significant differences in CD44V6 expression between normal ovarian tissue and benign ovarian tumor. However, the expression of CD44V6 in ovarian cancer was significantly elevated compared to normal ovaries and benign ovarian tumor. These results were supported by ELISA and western blot analysis. Immunohistochemistry showed that CD44V6 protein in ovarian cancer cells accumulated at high levels on the membrane of ovarian cancer cells. CD44V6 expression is closely associated with the tumorous transformation of ovarian tissue, suggesting that CD44V6 can promote the occurrence and progression of ovarian cancer.
View Figures
View References

Related Articles

Journal Cover

August-2017
Volume 14 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhang H, Hu P and Fang S: Understanding the role of CD44V6 in ovarian cancer. Oncol Lett 14: 1989-1992, 2017
APA
Zhang, H., Hu, P., & Fang, S. (2017). Understanding the role of CD44V6 in ovarian cancer. Oncology Letters, 14, 1989-1992. https://doi.org/10.3892/ol.2017.6377
MLA
Zhang, H., Hu, P., Fang, S."Understanding the role of CD44V6 in ovarian cancer". Oncology Letters 14.2 (2017): 1989-1992.
Chicago
Zhang, H., Hu, P., Fang, S."Understanding the role of CD44V6 in ovarian cancer". Oncology Letters 14, no. 2 (2017): 1989-1992. https://doi.org/10.3892/ol.2017.6377