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Article Open Access

Anticancer effects of liriodenine on the cell growth and apoptosis of human breast cancer MCF-7 cells through the upregulation of p53 expression

  • Authors:
    • Zhi‑Hua Li
    • Jin Gao
    • Ping‑Hua Hu
    • Jian‑Ping Xiong
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330009, P.R. China, Department of Breast Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China, Prevention and Cure Center of Breast Disease, Third Hospital of Nanchang, Nanchang, Jiangxi 330009, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1979-1984
    |
    Published online on: June 19, 2017
       https://doi.org/10.3892/ol.2017.6418
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Abstract

Liriodenine has wide pharmacological functions in phytochemistry, pharmacology and antitumor activities. The anticancer effects of liriodenine on the cell growth and apoptosis of human breast cancer MCF‑7 cells, and the underlying mechanisms, are yet to be elucidated. Therefore, the present study investigated the anticancer effects of liriodenine on the cell growth and apoptosis of human breast cancer MCF‑7 cells. We used MTT assay to measure cell growth, and flow cytometer and DAPI staining was used to analyze cell apoptosis. Then, Western blot analysis was executed to measure B‑cell lymphoma‑2 protein (Bcl‑2), cyclin D1, vascular endothelial growth factor (VEGF), and p53 protein expression. The effect of liriodenine induced significant apoptosis and suppression of cell growth of the MCF‑7 cells. Furthermore, the potential mechanism underlying its antitumor effect on MCF‑7 cells may result from activation of caspase‑3 activity, Bcl‑2, cyclin D1 and VEGF, and promotion of p53 protein expression in MCF‑7 cells. Therefore, the present results indicated that the anticancer effects of liriodenine suppress cell growth and induce the apoptosis of human breast cancer MCF‑7 cells through inhibition of Bcl‑2, cyclin D1 and VEGF expression, and upregulation of p53 expression. Therefore, liriodenine may be a potential therapy for the treatment of human breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Li ZH, Gao J, Hu PH and Xiong JP: Anticancer effects of liriodenine on the cell growth and apoptosis of human breast cancer MCF-7 cells through the upregulation of p53 expression. Oncol Lett 14: 1979-1984, 2017.
APA
Li, Z., Gao, J., Hu, P., & Xiong, J. (2017). Anticancer effects of liriodenine on the cell growth and apoptosis of human breast cancer MCF-7 cells through the upregulation of p53 expression. Oncology Letters, 14, 1979-1984. https://doi.org/10.3892/ol.2017.6418
MLA
Li, Z., Gao, J., Hu, P., Xiong, J."Anticancer effects of liriodenine on the cell growth and apoptosis of human breast cancer MCF-7 cells through the upregulation of p53 expression". Oncology Letters 14.2 (2017): 1979-1984.
Chicago
Li, Z., Gao, J., Hu, P., Xiong, J."Anticancer effects of liriodenine on the cell growth and apoptosis of human breast cancer MCF-7 cells through the upregulation of p53 expression". Oncology Letters 14, no. 2 (2017): 1979-1984. https://doi.org/10.3892/ol.2017.6418
Copy and paste a formatted citation
x
Spandidos Publications style
Li ZH, Gao J, Hu PH and Xiong JP: Anticancer effects of liriodenine on the cell growth and apoptosis of human breast cancer MCF-7 cells through the upregulation of p53 expression. Oncol Lett 14: 1979-1984, 2017.
APA
Li, Z., Gao, J., Hu, P., & Xiong, J. (2017). Anticancer effects of liriodenine on the cell growth and apoptosis of human breast cancer MCF-7 cells through the upregulation of p53 expression. Oncology Letters, 14, 1979-1984. https://doi.org/10.3892/ol.2017.6418
MLA
Li, Z., Gao, J., Hu, P., Xiong, J."Anticancer effects of liriodenine on the cell growth and apoptosis of human breast cancer MCF-7 cells through the upregulation of p53 expression". Oncology Letters 14.2 (2017): 1979-1984.
Chicago
Li, Z., Gao, J., Hu, P., Xiong, J."Anticancer effects of liriodenine on the cell growth and apoptosis of human breast cancer MCF-7 cells through the upregulation of p53 expression". Oncology Letters 14, no. 2 (2017): 1979-1984. https://doi.org/10.3892/ol.2017.6418
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