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Article Open Access

Expression and prognostic significance of miR-375 and miR-221 in liver cancer

  • Authors:
    • Dafei Xie
    • Peiwen Yuan
    • Dong Wang
    • Hua Jin
    • Hui Chen
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Zhejiang Hospital, Hangzhou, Zhejiang 310013, P.R. China, Intensive Care Unit, Zhejiang Hospital, Hangzhou, Zhejiang 310013, P.R. China
    Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2305-2309
    |
    Published online on: June 20, 2017
       https://doi.org/10.3892/ol.2017.6423
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Abstract

The purpose of this study was to investigate the expression of miR-375 and miR-221 in liver cancer, and examine the correlations with pathological parameters and prognosis. We collected tumors and tumor-adjacent normal tissue from 70 patients with liver cancer admitted to the Department of General Surgery of Zhejiang Hospital. The expression of miR-375 by RT-qPCR was significantly lower in liver cancer tissues than that in the tumor-adjacent normal tissues, and the low expression was correlated with the lymphatic metastasis and TNM stage. By contrast, the expression of miR-221 was significantly higher in liver cancer than that in the tumor-adjacent tissues, and the high expression was correlated with the lymphatic metastasis and TNM stage. The overall 5-year survival rate of patients was 12.9% (9/70). Single-factor survival analysis revealed that miR-375 and miR-221 were the factors affecting the overall survival rate of liver cancer (P<0.05) and multivariate survival analysis by Cox proportional hazards model showed that miR-375 and miR-221 were the independent factors affecting the survival time of patients with liver cancer. Low expression of miR-375 and high expression of miR-221 are closely correlated with the occurrence and development of liver cancer, especially lymphatic metastasis and TNM stage. Thus, miR-375 and miR-221 can serve as reference biomarkers for guiding the treatment of liver cancer and for estimating prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Xie D, Yuan P, Wang D, Jin H and Chen H: Expression and prognostic significance of miR-375 and miR-221 in liver cancer. Oncol Lett 14: 2305-2309, 2017.
APA
Xie, D., Yuan, P., Wang, D., Jin, H., & Chen, H. (2017). Expression and prognostic significance of miR-375 and miR-221 in liver cancer. Oncology Letters, 14, 2305-2309. https://doi.org/10.3892/ol.2017.6423
MLA
Xie, D., Yuan, P., Wang, D., Jin, H., Chen, H."Expression and prognostic significance of miR-375 and miR-221 in liver cancer". Oncology Letters 14.2 (2017): 2305-2309.
Chicago
Xie, D., Yuan, P., Wang, D., Jin, H., Chen, H."Expression and prognostic significance of miR-375 and miR-221 in liver cancer". Oncology Letters 14, no. 2 (2017): 2305-2309. https://doi.org/10.3892/ol.2017.6423
Copy and paste a formatted citation
x
Spandidos Publications style
Xie D, Yuan P, Wang D, Jin H and Chen H: Expression and prognostic significance of miR-375 and miR-221 in liver cancer. Oncol Lett 14: 2305-2309, 2017.
APA
Xie, D., Yuan, P., Wang, D., Jin, H., & Chen, H. (2017). Expression and prognostic significance of miR-375 and miR-221 in liver cancer. Oncology Letters, 14, 2305-2309. https://doi.org/10.3892/ol.2017.6423
MLA
Xie, D., Yuan, P., Wang, D., Jin, H., Chen, H."Expression and prognostic significance of miR-375 and miR-221 in liver cancer". Oncology Letters 14.2 (2017): 2305-2309.
Chicago
Xie, D., Yuan, P., Wang, D., Jin, H., Chen, H."Expression and prognostic significance of miR-375 and miR-221 in liver cancer". Oncology Letters 14, no. 2 (2017): 2305-2309. https://doi.org/10.3892/ol.2017.6423
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