Radiological and clinical features of primary NK/T-cell lymphoma involving the whole length of the esophagus: A case report

Liang,Pan; Ren,Xiu‑Chun; Gao,Jian‑Bo

doi:10.3892/ol.2017.6456

Radiological and clinical features of primary NK/T-cell lymphoma involving the whole length of the esophagus: A case report

Authors:
- Pan Liang
- Xiu‑Chun Ren
- Jian‑Bo Gao
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Affiliations: Department of Radiology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
Published online on: June 22, 2017 https://doi.org/10.3892/ol.2017.6456
Pages: 2147-2152
Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Primary esophageal natural killer (NK)/T‑cell lymphoma is a markedly rare tumor. There were only 6 cases of the disease identified prior to June 2015. In the present study, the aforementioned cases were validated, and relevant computed tomography (CT) results and clinical features of primary esophageal NK/T‑cell lymphoma were determined, to increase awareness of this type of tumor. CT features and clinical presentations of a patient with pathologically confirmed esophageal NK/T‑cell lymphoma was analyzed. The patient exhibited non‑specific clinical symptoms and CT images revealed diffuse thickening of the entire length of the esophagus. The patient received cycles of systemic chemotherapy and subsequent chest CT images demonstrated prompt and marked shrinkage of the tumor. At the time of writing, the patient has survived for 24 months and experiences a good quality of life without postprandial fullness or difficulty swallowing solid food. In addition, the characteristics of 6 patients with complete clinical features of this type of tumor, on the basis of a review of published studies (online PubMed, Medline, Google Scholar, Chinese Biomedicine Database and China Journal Full Text Database search), were retrospectively analyzed. Although primary esophageal NK/T‑cell lymphoma is a markedly rare tumor, it is considered to be included in differential diagnosis of patients presenting with a fungal or viral infection, therapy‑related mucositis or reflux esophagitis. The final diagnosis of primary esophageal NK/T‑cell lymphoma is on the basis of a combination of clinical, CT and histopathological results.

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1	Wu X, Li P, Zhao J, Yang X, Wang F, Yang YQ, Fang F, Xu Y, Zhang H, Wang WY and Yi C: A clinical study of 115 patients with extranodal natural killer/T-cell lymphoma, nasal type. Clin Oncol (R Coll Radiol). 20:619–625. 2008. View Article : Google Scholar : PubMed/NCBI
2	Ghimire P, Wu GY and Zhu L: Primary esophageal lymphoma in immunocompetent patients: Two case reports and literature review. World J Radiol. 2:334–338. 2010. View Article : Google Scholar : PubMed/NCBI
3	Mori T, Komeno T and Ohtani H: Mantle cell lymphoma-like solitary polypoid tumor of the esophagus: A case report. Cases J. 2:66462009. View Article : Google Scholar : PubMed/NCBI
4	Zhang S, Wang H and Leng DN: Clinicopathological observation on 2 cases of nasal-type NK/T-cell lymphoma in the esophagus. Zhonghua Zhong Liu Za Zhi. 30:767–769. 2008.(In Chinese). PubMed/NCBI
5	Lee SR, Park EK, Won NH and Kim BS: Esophageal involvement by extranodal natural killer T cell lymphoma, nasal type, mimicking Epstein Barr viral esophagitis in a tonsillar lymphoma patient undergoing chemoradiation therapy. Asia Pac J Clin Oncol. 6:149–154. 2010. View Article : Google Scholar : PubMed/NCBI
6	Fujihara S, Mori H, Kobara H, Nishiyama N, Kobayashi M and Masaki T: Esophageal natural killer (NK)/T cell lymphoma of true natural killer cell origin. Endoscopy. 46 Suppl 1 UCTN:E77–E78. 2014. View Article : Google Scholar : PubMed/NCBI
7	Song Y, Huang Y, Hu Y and He C: Primary NK/T cell lymphoma of the esophagus: A case report. Chin J Oncol. 400:2014.(In Chinese).
8	Tang J and Li D: Primary extranodal NK/T cell lymphoma, nasal type of the esophagus-gastric cardia: A case report. Chin J Diffic Compl Cas. 645–66. 2014.(In Chinese).
9	Hosaka S, Nakamura N, Akamatsu T, Fujisawa T, Ogiwara Y, Kiyosawa K, Hidaka E, Ota H, Katsuyama T and Inagaki H: A case of primary low grade mucosa associated lymphoid tissue (MALT) lymphoma of the oesophagus. Gut. 51:281–284. 2002. View Article : Google Scholar : PubMed/NCBI
10	Taal BG, Van Heerde P and Somers R: Isolated primary oesophageal involvement by lymphoma: A rare cause of dysphagia: Two case histories and a review of other published data. Gut. 34:994–998. 1993. View Article : Google Scholar : PubMed/NCBI
11	Li JZ, Tao J, Ruan DY, Yang YD, Zhan YS, Wang X, Chen Y, Kuang SC, Shao CK and Wu B: Primary duodenal NK/T-cell lymphoma with massive bleeding: A case report. World J Clin Oncol. 3:92–97. 2012. View Article : Google Scholar : PubMed/NCBI
12	Zheng S, Ouyang Q, Li G, Xu H, Jiang M, Cui D, Xue L and Li J: Primary intestinal NK/T cell lymphoma: A clinicopathologic study of 25 Chinese cases. Arch Iran Med. 15:36–42. 2012.PubMed/NCBI
13	Bandyopadhyay SK, Moulick A and Dutta A: Primary duodenal lymphoma producing obstructive jaundice. J Assoc Physicians India. 55:76–77. 2007.PubMed/NCBI
14	Coppens E, El Nakadi I, Nagy N and Zalcman M: Primary Hodgkin's lymphoma of the esophagus. AJR Am J Roentgenol. 180:1335–1337. 2003. View Article : Google Scholar : PubMed/NCBI
15	Radin DR: Primary esophageal lymphoma in AIDS. Abdom Imaging. 18:223–224. 1993. View Article : Google Scholar : PubMed/NCBI
16	Doki T, Hamada S, Murayama H, Suenaga H and Sannohe Y: Primary malignant lymphoma of the esophagus. A case report. Endoscopy. 16:189–192. 1984. View Article : Google Scholar : PubMed/NCBI
17	Kalogeropoulos IV, Chalazonitis AN, Tsolaki S, Laspas F, Ptohis N, Neofytou I and Rontogianni D: A case of primary isolated non-Hodgkin's lymphoma of the esophagus in an immunocompetent patient. World J Gastroenterol. 15:1901–1903. 2009. View Article : Google Scholar : PubMed/NCBI
18	Lin CC, Lai HW, Tsai MC, Chen TH, Tseng SW, Chang H and Chen TY: Extranodal marginal zone B-cell lymphoma of the gastrointestinal tract sparing only the esophagus: A case report. Turk J Gastroenterol. 23:58–62. 2012. View Article : Google Scholar : PubMed/NCBI
19	Kurihara K, Fukui A and Kumano S: Malignant lymphoma of the esophagus associated with macroglobulinemia: Report of a case. Pathol Int. 44:712–715. 1994. View Article : Google Scholar : PubMed/NCBI
20	Kim TM, Lee SY, Jeon YK, Ryoo BY, Cho GJ, Hong YS, Kim HJ, Kim SY, Kim CS, Kim S, et al: Clinical heterogeneity of extranodal NK/T-cell lymphoma, nasal type: A national survey of the Korean cancer study group. Ann Oncol. 19:1477–1484. 2008. View Article : Google Scholar : PubMed/NCBI
21	Bautista-Quach MA, Ake CD, Chen M and Wang J: Gastrointestinal lymphomas: Morphology, immunophenotype and molecular features. J Gastrointest Oncol. 3:209–225. 2012.PubMed/NCBI
22	Jaffe ES, Chan JK, Su IJ, Frizzera G, Mori S, Feller AC and Ho FC: Report of the workshop on nasal and related extranodal angiocentric T/Natural killer cell lymphomas. definitions, differential diagnosis and epidemiology. Am J Surg Pathol. 20:103–111. 1996. View Article : Google Scholar : PubMed/NCBI
23	Crook TW and Robinson RA: Dysphagia in a patient with a history of large B-cell lymphoma: Esophageal disease with negative biopsy findings. Diagn Cytopathol. 26:167–169. 2002. View Article : Google Scholar : PubMed/NCBI
24	Kim JH, Lee JH, Lee J, Oh SO, Chang DK, Rhee PL, Kim JJ, Rhee JC, Lee J, Kim WS and Ko YH: Primary NK-/T-cell lymphoma of the gastrointestinal tract: Clinical characteristics and endoscopic findings. Endoscopy. 39:156–160. 2007. View Article : Google Scholar : PubMed/NCBI
25	Santra G: Oesophageal involvement in mantle cell lymphoma. Singapore Med J. 51:e201–e203. 2010.PubMed/NCBI