Open Access

Delineation of retroperitoneal metastatic lymph nodes in ovarian cancer with near‑infrared fluorescence imaging

  • Authors:
    • Tao Pu
    • Liqin Xiong
    • Qiyu Liu
    • Minxing Zhang
    • Qingqing Cai
    • Haiou Liu
    • Anil K. Sood
    • Guiling Li
    • Yu Kang
    • Congjian Xu
  • View Affiliations

  • Published online on: July 5, 2017     https://doi.org/10.3892/ol.2017.6521
  • Pages: 2869-2877
  • Copyright: © Pu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lymph node metastasis occurs in early‑stage and late‑stage ovarian cancers. Systematic lymphadenectomy is frequently conducted in an attempt to prevent disease progression. However, this method is associated with multiple complications. Therefore, it is necessary to develop a less invasive and more sensitive method for detecting lymphatic metastasis in ovarian cancer. The aim of the present study was to develop an appropriate fluorescent label for the analysis of lymphatic metastasis in vivo. To this end, epithelial ovarian cancer cells with high potential for lymph node metastasis were labeled using mCherry fluorescence. The cells were then imaged in vitro to determine the expression of mCherry, and in a mouse xenograft model in vivo. The data demonstrated the successful identification of metastatic retroperitoneal lymph nodes by co‑localization with lymph nodes labeled by near‑infrared fluorescence nanoparticles in vivo. These data provided important insights into the further development of methods for intra‑operative identification of lymphatic metastasis and the mechanisms underlying lymphatic metastasis.
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September-2017
Volume 14 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Pu T, Xiong L, Liu Q, Zhang M, Cai Q, Liu H, Sood AK, Li G, Kang Y, Xu C, Xu C, et al: Delineation of retroperitoneal metastatic lymph nodes in ovarian cancer with near‑infrared fluorescence imaging. Oncol Lett 14: 2869-2877, 2017.
APA
Pu, T., Xiong, L., Liu, Q., Zhang, M., Cai, Q., Liu, H. ... Xu, C. (2017). Delineation of retroperitoneal metastatic lymph nodes in ovarian cancer with near‑infrared fluorescence imaging. Oncology Letters, 14, 2869-2877. https://doi.org/10.3892/ol.2017.6521
MLA
Pu, T., Xiong, L., Liu, Q., Zhang, M., Cai, Q., Liu, H., Sood, A. K., Li, G., Kang, Y., Xu, C."Delineation of retroperitoneal metastatic lymph nodes in ovarian cancer with near‑infrared fluorescence imaging". Oncology Letters 14.3 (2017): 2869-2877.
Chicago
Pu, T., Xiong, L., Liu, Q., Zhang, M., Cai, Q., Liu, H., Sood, A. K., Li, G., Kang, Y., Xu, C."Delineation of retroperitoneal metastatic lymph nodes in ovarian cancer with near‑infrared fluorescence imaging". Oncology Letters 14, no. 3 (2017): 2869-2877. https://doi.org/10.3892/ol.2017.6521