Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2017 Volume 14 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2017 Volume 14 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Disrupted fibroblastic reticular cells and interleukin‑7 expression in tumor draining lymph nodes

  • Authors:
    • Jianbao Gao
    • Lintao Zhao
    • Lina Liu
    • Yang Yang
    • Bo Guo
    • Bo Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2954-2960
    |
    Published online on: July 7, 2017
       https://doi.org/10.3892/ol.2017.6537
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The immune system of patients with cancer is usually in an inhibitory state. Lymph node (LN) draining of pathological sites provides a suitable microenvironment where adaptive immune responses mainly occur. However, the microenvironment in the tumor draining lymph nodes (TDLNs) of patients with cancer appears to be in favor of tolerance. The effects of tumor cells on TDLNs have not been elaborated clearly. The present results have indicated that tumor cells may directly affect TDLNs by decreasing the fibroblastic reticular cell population that led to less interleukin‑7 secretion. As a result, the number of T cells in TDLNs declined with reduced survival signals. A decreased number of T cells in TDLNs means weakened ability of immune surveillance. Clinically, these results were also confirmed in LN biopsies from patients with colon cancer at different clinical stages. Results of the present study showed that tumor cells may directly inhibit the immunological function of TDLNs.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Gao J, Zhao L, Wan YY and Zhu B: Mechanism of action of IL-7 and its potential applications and limitations in cancer immunotherapy. Int J Mol Sci. 16:10267–10280. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Lindau D, Gielen P, Kroesen M, Wesseling P and Adema GJ: The immunosuppressive tumour network: Myeloid-derived suppressor cells, regulatory T cells and natural killer T cells. Immunology. 138:105–115. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Malhotra D, Fletcher AL and Turley SJ: Stromal and hematopoietic cells in secondary lymphoid organs: Partners in immunity. Immunol Rev. 251:160–176. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Munn DH and Mellor AL: The tumor-draining lymph node as an immune-privileged site. Immunol Rev. 213:146–158. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Turley SJ, Fletcher AL and Elpek KG: The stromal and haematopoietic antigen-presenting cells that reside in secondary lymphoid organs. Nat Rev Immunol. 10:813–825. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Bajenoff M, Egen JG, Koo LY, Laugier JP, Brau F, Glaichenhaus N and Germain RN: Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity. 25:989–1001. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Zhao L, Gao J, Li Y, Liu L, Yang Y, Guo B and Zhu B: Disrupted homeostatic cytokines expression in secondary lymph organs during HIV infection. Int J Mol Sci. 17:4132016. View Article : Google Scholar : PubMed/NCBI

9 

Zhao L, Chen J, Liu L, Gao J, Guo B and Zhu B: Essential role of TNF-alpha in development of spleen fibroblastic reticular cells. Cell Immunol. 293:130–136. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Link A, Vogt TK, Favre S, Britschgi MR, Acha-Orbea H, Hinz B, Cyster JG and Luther SA: Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol. 8:1255–1265. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Mueller SN and Germain RN: Stromal cell contributions to the homeostasis and functionality of the immune system. Nat Rev Immunol. 9:618–629. 2009.PubMed/NCBI

12 

Onder L, Narang P, Scandella E, Chai Q, Iolyeva M, Hoorweg K, Halin C, Richie E, Kaye P, Westermann J, et al: IL-7-producing stromal cells are critical for lymph node remodeling. Blood. 120:4675–4683. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Fletcher AL, Malhotra D and Turley SJ: Lymph node stroma broaden the peripheral tolerance paradigm. Trends Immunol. 32:12–18. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Lee JW, Epardaud M, Sun J, Becker JE, Cheng AC, Yonekura AR, Heath JK and Turley SJ: Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat Immunol. 8:181–190. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Dubrot J, Duraes FV, Potin L, Capotosti F, Brighouse D, Suter T, LeibundGut-Landmann S, Garbi N, Reith W, Swartz MA and Hugues S: Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4+ T cell tolerance. J Exp Med. 211:1153–1166. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Kittipatarin C and Khaled AR: Interlinking interleukin-7. Cytokine. 39:75–83. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Surh CD and Sprent J: Homeostasis of naive and memory T cells. Immunity. 29:848–862. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Rathmell JC, Farkash EA, Gao W and Thompson CB: IL-7 enhances the survival and maintains the size of naive T cells. J Immunol. 167:6869–6876. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Fry TJ and Mackall CL: The many faces of IL-7: From lymphopoiesis to peripheral T cell maintenance. J Immunol. 174:6571–6576. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Chappaz S and Finke D: The IL-7 signaling pathway regulates lymph node development independent of peripheral lymphocytes. J Immunol. 184:3562–3569. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Chappaz S, Gärtner C, Rodewald HR and Finke D: Kit ligand and Il7 differentially regulate Peyer's patch and lymph node development. J Immunol. 185:3514–3519. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Schmutz S, Bosco N, Chappaz S, Boyman O, Acha-Orbea H, Ceredig R, Rolink AG and Finke D: Cutting edge: IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells. J Immunol. 183:2217–2221. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Dukes CE: The surgical pathology of rectal cancer: President's address. Proc R Soc Med. 37:131–144. 1944.PubMed/NCBI

24 

Fletcher AL, Malhotra D, Acton SE, Lukacs-Kornek V, Bellemare-Pelletier A, Curry M, Armant M and Turley SJ: Reproducible isolation of lymph node stromal cells reveals site-dependent differences in fibroblastic reticular cells. Front Immunol. 2:352011. View Article : Google Scholar : PubMed/NCBI

25 

Sawa Y, Arima Y, Ogura H, Kitabayashi C, Jiang JJ, Fukushima T, Kamimura D, Hirano T and Murakami M: Hepatic interleukin-7 expression regulates T cell responses. Immunity. 30:447–457. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Zeng M, Paiardini M, Engram JC, Beilman GJ, Chipman JG, Schacker TW, Silvestri G and Haase AT: Critical role of CD4 T cells in maintaining lymphoid tissue structure for immune cell homeostasis and reconstitution. Blood. 120:1856–1867. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Zeng M, Smith AJ, Wietgrefe SW, Southern PJ, Schacker TW, Reilly CS, Estes JD, Burton GF, Silvestri G, Lifson JD, et al: Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections. J Clin Invest. 121:998–1008. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Astarita JL, Acton SE and Turley SJ: Podoplanin: Emerging functions in development, the immune system, and cancer. Front Immunol. 3:2832012. View Article : Google Scholar : PubMed/NCBI

30 

de Aquino MT, Malhotra A, Mishra MK and Shanker A: Challenges and future perspectives of T cell immunotherapy in cancer. Immunol Lett. 166:117–133. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Gorelik L and Flavell RA: Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells. Nat Med. 7:1118–1122. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Wang Y, Han G, Wang K, Liu G, Wang R, Xiao H, Li X, Hou C, Shen B, Guo R, et al: Tumor-derived GM-CSF promotes inflammatory colon carcinogenesis via stimulating epithelial release of VEGF. Cancer Res. 74:716–726. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Mueller SN, Matloubian M, Clemens DM, Sharpe AH, Freeman GJ, Gangappa S, Larsen CP and Ahmed R: Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proc Natl Acad Sci USA. 104:15430–15435. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Choi YK, Fallert BA, Murphey-Corb MA and Reinhart TA: Simian immunodeficiency virus dramatically alters expression of homeostatic chemokines and dendritic cell markers during infection in vivo. Blood. 101:1684–1691. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Zeng M, Haase AT and Schacker TW: Lymphoid tissue structure and HIV-1 infection: Life or death for T cells. Trends Immunol. 33:306–314. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Soudja SM, Henri S, Mello M, Chasson L, Mas A, Wehbe M, Auphan-Anezin N, Leserman L, Van den Eynde B and Schmitt-Verhulst AM: Disrupted lymph node and splenic stroma in mice with induced inflammatory melanomas is associated with impaired recruitment of T and dendritic cells. PloS One. 6:e226392011. View Article : Google Scholar : PubMed/NCBI

37 

Imai K, Minamiya Y, Koyota S, Ito M, Saito H, Sato Y, Motoyama S, Sugiyama T and Ogawa J: Inhibition of dendritic cell migration by transforming growth factor-β1 increases tumor-draining lymph node metastasis. J Exp Clin Cancer Res. 31:32012. View Article : Google Scholar : PubMed/NCBI

38 

Tang J, Nuccie BL, Ritterman I, Liesveld JL, Abboud CN and Ryan DH: TGF-beta down-regulates stromal IL-7 secretion and inhibits proliferation of human B cell precursors. J Immunol. 159:117–125. 1997.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gao J, Zhao L, Liu L, Yang Y, Guo B and Zhu B: Disrupted fibroblastic reticular cells and interleukin‑7 expression in tumor draining lymph nodes. Oncol Lett 14: 2954-2960, 2017.
APA
Gao, J., Zhao, L., Liu, L., Yang, Y., Guo, B., & Zhu, B. (2017). Disrupted fibroblastic reticular cells and interleukin‑7 expression in tumor draining lymph nodes. Oncology Letters, 14, 2954-2960. https://doi.org/10.3892/ol.2017.6537
MLA
Gao, J., Zhao, L., Liu, L., Yang, Y., Guo, B., Zhu, B."Disrupted fibroblastic reticular cells and interleukin‑7 expression in tumor draining lymph nodes". Oncology Letters 14.3 (2017): 2954-2960.
Chicago
Gao, J., Zhao, L., Liu, L., Yang, Y., Guo, B., Zhu, B."Disrupted fibroblastic reticular cells and interleukin‑7 expression in tumor draining lymph nodes". Oncology Letters 14, no. 3 (2017): 2954-2960. https://doi.org/10.3892/ol.2017.6537
Copy and paste a formatted citation
x
Spandidos Publications style
Gao J, Zhao L, Liu L, Yang Y, Guo B and Zhu B: Disrupted fibroblastic reticular cells and interleukin‑7 expression in tumor draining lymph nodes. Oncol Lett 14: 2954-2960, 2017.
APA
Gao, J., Zhao, L., Liu, L., Yang, Y., Guo, B., & Zhu, B. (2017). Disrupted fibroblastic reticular cells and interleukin‑7 expression in tumor draining lymph nodes. Oncology Letters, 14, 2954-2960. https://doi.org/10.3892/ol.2017.6537
MLA
Gao, J., Zhao, L., Liu, L., Yang, Y., Guo, B., Zhu, B."Disrupted fibroblastic reticular cells and interleukin‑7 expression in tumor draining lymph nodes". Oncology Letters 14.3 (2017): 2954-2960.
Chicago
Gao, J., Zhao, L., Liu, L., Yang, Y., Guo, B., Zhu, B."Disrupted fibroblastic reticular cells and interleukin‑7 expression in tumor draining lymph nodes". Oncology Letters 14, no. 3 (2017): 2954-2960. https://doi.org/10.3892/ol.2017.6537
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team