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CD55 and CD59 expression protects HER2‑overexpressing breast cancer cells from trastuzumab‑induced complement‑dependent cytotoxicity

  • Authors:
    • Yu Wang
    • Ya‑Jun Yang
    • Zhu Wang
    • Juan Liao
    • Mei Liu
    • Xiao‑Rong Zhong
    • Hong Zheng
    • Yan‑Ping Wang
  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Diagnosis of Cancer, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2961-2969
    |
    Published online on: July 8, 2017
       https://doi.org/10.3892/ol.2017.6555
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Abstract

A large proportion (40‑60%) of patients with human epidermal growth factor receptor 2 (HER2)‑overexpressing breast cancer do not benefit from trastuzumab treatment, potentially due to the lack of complement‑dependent cytotoxicity (CDC) activation. In the present study, the effect of complement decay‑accelerating factor (CD55) and CD59 glycoprotein precursor (CD59) expression on trastuzumab‑induced CDC in HER2‑positive breast cancer cell lines was investigated. The CD55 and CD59‑overexpressing and HER2‑positive cell lines SK‑BR‑3 and BT474 were selected for subsequent experiments. Blocking CD55 and CD59 function using targeting monoclonal antibodies significantly enhanced the cell lysis of SK‑BR‑3 and BT474 cells following treatment with trastuzumab. In addition, following treatment with 0.1 U/ml phosphatidylinositol‑specific phospholipase C (PI‑PLC) for 1 h, CD55 and CD59 surface expression was significantly decreased, and the cell lysis rate was further enhanced. Treatment of SK‑BR‑3 cells with short hairpin RNA (shRNA) targeting CD55 and CD59 downregulated CD55 and CD59 expression at the mRNA and protein levels, and resulted in significantly enhanced trastuzumab‑induced CDC‑dependent lysis. The data from the present study suggested that CD55 and CD59 serve roles in blocking trastuzumab‑induced CDC, therefore strategies targeting CD55 and CD59 may overcome breast cancer cell resistance to trastuzumab. The results from the present study may provide a basis for developing suitable, personalized treatment strategies to improve the clinical efficacy of trastuzumab for patients with HER2‑positive breast cancer.
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1 

Servick K: Breast cancer. Breast cancer: A world of differences. Science. 343:1452–1453. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Thomas E and Berner G: Prognostic and predictive implications of HER2 status for breast cancer patients. Eur J Oncol Nurs. 4:10–17. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Cardoso F, Piccart MJ, Durbecq V and Di Leo A: Resistance to trastuzumab: A necessary evil or a temporary challenge? Clin Breast Cancer. 3:247–259. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Scott AM, Wolchok JD and Old LJ: Antibody therapy of cancer. Nat Rev Cancer. 12:278–287. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Mineo JF, Bordron A, Quintin-Roué I, Loisel S, Ster KL, Buhé V, Lagarde N and Berthou C: Recombinant humanised anti-HER2/neu antibody (Herceptin) induces cellular death of glioblastomas. Br J Cancer. 91:1195–1199. 2004.PubMed/NCBI

6 

Prang N, Preithner S, Brischwein K, Göster P, Wöppel A, Müller J, Steiger C, Peters M, Baeuerle PA and da Silva AJ: Cellular and complement-dependent cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell lines. Br J Cancer. 92:342–349. 2005.PubMed/NCBI

7 

Fishelson Z, Donin N, Zell S, Schultz S and Kirschfink M: Obstacles to cancer immunotherapy: Expression of membrane complement regulatory proteins (mCRPs) in tumors. Mol Immunol. 40:109–123. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Macor P and Tedesco F: Complement as effector system in cancer immunotherapy. Immunol Lett. 111:6–13. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Wu Y, Wang Y, Qin F, Wang Z, Wang Y, Yang Y and Zheng H and Zheng H: CD55 limits sensitivity to complement-dependent cytolysis triggered by heterologous expression of α-gal xenoantigen in colon tumor cells. Am J Physiol Gastrointest Liver Physiol. 306:G1056–G1064. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Liu M, Yang YJ, Zheng H, Zhong XR, Wang Y, Wang Z, Wang YG and Wang YP: Membrane-bound complement regulatory proteins are prognostic factors of operable breast cancer treated with adjuvant trastuzumab: A retrospective study. Oncol Rep. 32:2619–2627. 2014.PubMed/NCBI

11 

Shi XX, Zhang B, Zang JL, Wang GY and Gao MH: CD59 silencing via retrovirus-mediated RNA interference enhanced complement-mediated cell damage in ovary cancer. Cell Mol Immunol. 6:61–66. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Reichert JM: Antibody-based therapeutics to watch in 2011. MAbs. 3:76–99. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Strome SE, Sausville EA and Mann D: A mechanistic perspective of monoclonal antibodies in cancer therapy beyond target-related effects. Oncologist. 12:1084–1095. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Clark MR: IgG effector mechanisms. Chem Immunol. 65:88–110. 1997. View Article : Google Scholar : PubMed/NCBI

16 

Dalle S, Thieblemont C, Thomas L and Dumontet C: Monoclonal antibodies in clinical oncology. Anticancer Agents Med Chem. 8:523–532. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Dean-Colomb W and Esteva FJ: Her2-positive breast cancer: Herceptin and beyond. Eur J Cancer. 44:2806–2812. 2008. View Article : Google Scholar : PubMed/NCBI

18 

De Lorenzo C, Tedesco A, Terrazzano G, Cozzolino R, Laccetti P, Piccoli R and D'Alessio G: A human, compact, fully functional anti-ErbB2 antibody as a novel antitumour agent. Br J Cancer. 91:1200–1204. 2004.PubMed/NCBI

19 

Yu J, Caragine T, Chen S, Morgan BP, Frey AB and Tomlinson S: Protection of human breast cancer cells from complement-mediated lysis by expression of heterologous CD59. Clin Exp Immunol. 115:13–18. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Gelderman KA, Tomlinson S, Ross GD and Gorter A: Complement function in mAb-mediated cancer immunotherapy. Trends Immunol. 25:158–164. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Yan J, Allendorf DJ, Li B, Yan R, Hansen R and Donev R: The role of membrane complement regulatory proteins in cancer immunotherapy. Adv Exp Med Biol. 632:159–174. 2008.PubMed/NCBI

22 

Jurianz K, Ziegler S, Garcia-Schüler H, Kraus S, Bohana-Kashtan O, Fishelson Z and Kirschfink M: Complement resistance of tumor cells: Basal and induced mechanisms. Mol Immunol. 36:929–939. 1999. View Article : Google Scholar : PubMed/NCBI

23 

Gancz D and Fishelson Z: Cancer resistance to complement-dependent cytotoxicity (CDC): Problem-oriented research and development. Mol Immunol. 46:2794–2800. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Rushmere NK, Knowlden JM, Gee JM, Harper ME, Robertson JF, Morgan BP and Nicholson RI: Analysis of the level of mRNA expression of the membrane regulators of complement, CD59, CD55, and CD46, in breast cancer. Int J Cancer. 108:930–936. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Ravindranath NM and Shuler C: Cell-surface density of complement restriction factors (CD46, CD55 and CD59): Oral squamous cell carcinoma versus other solid tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 103:231–239. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Loberg RD, Wojno KJ, Day LL and Pienta KJ: Analysis of membrane-bound complement regulatory proteins in prostate cancer. Urology. 66:1321–1326. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Madjd Z, Durrant LG, Bradley R, Spendlove I, Ellis IO and Pinder SE: Loss of CD55 is associated with aggressive breast tumors. Clin Cancer Res. 10:2797–2803. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Zell S, Geis N, Rutz R, Schultz S, Giese T and Kirschfink M: Down-regulation of CD55 and CD46 expression by anti-sense phosphorothioate oligonucleotides (S-ODNs) sensitizes tumour cells to complement attack. Clin Exp Immunol. 150:576–584. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Jurianz K, Maslak S, Garcia-Schuler H, Fishelson Z and Kirschfink M: Neutralization of complement regulatory proteins augments lysis of breast carcinoma cells targeted with rhumAb anti-HER2. Immunopharmacology. 42:209–218. 1999. View Article : Google Scholar : PubMed/NCBI

30 

Macor P, Tripodo C, Zorzet S, Piovan E, Bossi F, Marzari R, Amadori A and Tedesco F: In vivo targeting of human neutralizing antibodies against CD55 and CD59 to lymphoma cells increases the antitumor activity of rituximab. Cancer Res. 67:10556–10563. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Golay J, Lazzari M, Facchinetti V, Bernasconi S, Borleri G, Barbui T, Rambaldi A and Introna M: CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: Further regulation by CD55 and CD59. Blood. 98:3383–3389. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Zhou X, Hu W and Qin X: The role of complement in the mechanism of action of rituximab for B-cell lymphoma: Implications for therapy. Oncologist. 13:954–966. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Nicholson-Weller A and Wang CE: Structure and function of decay accelerating factor CD55. J Lab Clin Med. 123:485–491. 1994.PubMed/NCBI

34 

Fonsatti E, Altomonte M, Coral S, De Nardo C, Lamaj E, Sigalotti L, Natali PG and Maio M: Emerging role of protectin (CD59) in humoral immunotherapy of solid malignancies. Clin Ter. 151:187–193. 2000.PubMed/NCBI

35 

Brasoveanu LI, Altomonte M, Fonsatti E, Colizzi F, Coral S, Nicotra MR, Cattarossi I, Cattelan A, Natali PG and Maio M: Levels of cell membrane CD59 regulate the extent of complement-mediated lysis of human melanoma cells. Lab Invest. 74:33–42. 1996.PubMed/NCBI

36 

Azuma A, Yamano Y, Yoshimura A, Hibino T, Nishida T, Yagita H, Okumura K, Seya T, Kannagi R, Shibuya M, et al: Augmented lung adenocarcinoma cytotoxicity by the combination of a genetically modified anti-Lewis Y antibody and antibodies to complement regulatory proteins. Scand J Immunol. 42:202–208. 1995. View Article : Google Scholar : PubMed/NCBI

37 

Bjorge L, Hakulinen J, Wahlström T, Matre R and Meri S: Complement-regulatory proteins in ovarian malignancies. Int J Cancer. 70:14–25. 1997. View Article : Google Scholar : PubMed/NCBI

38 

Aagaard L and Rossi JJ: RNAi therapeutics: Principles, prospects and challenges. Adv Drug Deliv Rev. 59:75–86. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Bellone S, Roque D, Cocco E, Gasparrini S, Bortolomai I, Buza N, Abu-Khalaf M, Silasi DA, Ratner E, Azodi M, et al: Downregulation of membrane complement inhibitors CD55 and CD59 by siRNA sensitises uterine serous carcinoma overexpressing Her2/neu to complement and antibody-dependent cell cytotoxicity in vitro: Implications for trastuzumab-based immunotherapy. Br J Cancer. 106:1543–1550. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Mamidi S, Cinci M, Hasmann M, Fehring V and Kirschfink M: Lipoplex mediated silencing of membrane regulators (CD46, CD55 and CD59) enhances complement-dependent anti-tumor activity of trastuzumab and pertuzumab. Mol Oncol. 7:580–594. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Yang YJ, Wang Z, Liao J, Liu M, Zhong XR, Zheng H and Wang YP: CD55 and CD59 expression protects HER2‑overexpressing breast cancer cells from trastuzumab‑induced complement‑dependent cytotoxicity. Oncol Lett 14: 2961-2969, 2017.
APA
Wang, Y., Yang, Y., Wang, Z., Liao, J., Liu, M., Zhong, X. ... Wang, Y. (2017). CD55 and CD59 expression protects HER2‑overexpressing breast cancer cells from trastuzumab‑induced complement‑dependent cytotoxicity. Oncology Letters, 14, 2961-2969. https://doi.org/10.3892/ol.2017.6555
MLA
Wang, Y., Yang, Y., Wang, Z., Liao, J., Liu, M., Zhong, X., Zheng, H., Wang, Y."CD55 and CD59 expression protects HER2‑overexpressing breast cancer cells from trastuzumab‑induced complement‑dependent cytotoxicity". Oncology Letters 14.3 (2017): 2961-2969.
Chicago
Wang, Y., Yang, Y., Wang, Z., Liao, J., Liu, M., Zhong, X., Zheng, H., Wang, Y."CD55 and CD59 expression protects HER2‑overexpressing breast cancer cells from trastuzumab‑induced complement‑dependent cytotoxicity". Oncology Letters 14, no. 3 (2017): 2961-2969. https://doi.org/10.3892/ol.2017.6555
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Yang YJ, Wang Z, Liao J, Liu M, Zhong XR, Zheng H and Wang YP: CD55 and CD59 expression protects HER2‑overexpressing breast cancer cells from trastuzumab‑induced complement‑dependent cytotoxicity. Oncol Lett 14: 2961-2969, 2017.
APA
Wang, Y., Yang, Y., Wang, Z., Liao, J., Liu, M., Zhong, X. ... Wang, Y. (2017). CD55 and CD59 expression protects HER2‑overexpressing breast cancer cells from trastuzumab‑induced complement‑dependent cytotoxicity. Oncology Letters, 14, 2961-2969. https://doi.org/10.3892/ol.2017.6555
MLA
Wang, Y., Yang, Y., Wang, Z., Liao, J., Liu, M., Zhong, X., Zheng, H., Wang, Y."CD55 and CD59 expression protects HER2‑overexpressing breast cancer cells from trastuzumab‑induced complement‑dependent cytotoxicity". Oncology Letters 14.3 (2017): 2961-2969.
Chicago
Wang, Y., Yang, Y., Wang, Z., Liao, J., Liu, M., Zhong, X., Zheng, H., Wang, Y."CD55 and CD59 expression protects HER2‑overexpressing breast cancer cells from trastuzumab‑induced complement‑dependent cytotoxicity". Oncology Letters 14, no. 3 (2017): 2961-2969. https://doi.org/10.3892/ol.2017.6555
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