miRNA‑346 promotes proliferation, migration and invasion in liver cancer

  • Authors:
    • Qiang Yu
    • Xia Yang
    • Weidong Duan
    • Chonghui Li
    • Ying Luo
    • Shichun Lu
  • View Affiliations

  • Published online on: July 8, 2017     https://doi.org/10.3892/ol.2017.6561
  • Pages: 3255-3260
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Abstract

Liver cancer primarily accounts for the majority of malignancies of the liver. MicroRNAs (miRNAs) are endogenous non‑coding RNAs, which are important in tumorigenesis. Abnormal expression of microRNA‑346 (miR‑346) has been demonstrated in various types of human cancer, however, its expression and potential molecular mechanism in liver cancer remains to be elucidated. Expression levels of miR‑346 in liver cancer cell lines were determined by quantitative polymerase chain reaction. The effect of miR‑346 on proliferation was evaluated by an MTT assay; cell migration and invasion were evaluated by Transwell migration and invasion assays and target protein expression was determined by western blotting. The present study observed that miR‑346 was upregulated in liver cancer cell lines. miR‑346 overexpression promoted cell proliferation, migration and invasion in liver cancer cells and conversely, inhibition of miR‑346 resulted in the opposite effects. Furthermore, F‑Box and leucine rich repeat protein (FBXL)2 was identified as a direct target of miR‑346. miR‑346 promoted proliferation, migration and invasion of liver cancer via FBXL2. Overall, these findings demonstrated that miR‑346 may act as a potential prognostic marker and therapeutic target against liver cancer in the future.
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September-2017
Volume 14 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yu Q, Yang X, Duan W, Li C, Luo Y and Lu S: miRNA‑346 promotes proliferation, migration and invasion in liver cancer. Oncol Lett 14: 3255-3260, 2017
APA
Yu, Q., Yang, X., Duan, W., Li, C., Luo, Y., & Lu, S. (2017). miRNA‑346 promotes proliferation, migration and invasion in liver cancer. Oncology Letters, 14, 3255-3260. https://doi.org/10.3892/ol.2017.6561
MLA
Yu, Q., Yang, X., Duan, W., Li, C., Luo, Y., Lu, S."miRNA‑346 promotes proliferation, migration and invasion in liver cancer". Oncology Letters 14.3 (2017): 3255-3260.
Chicago
Yu, Q., Yang, X., Duan, W., Li, C., Luo, Y., Lu, S."miRNA‑346 promotes proliferation, migration and invasion in liver cancer". Oncology Letters 14, no. 3 (2017): 3255-3260. https://doi.org/10.3892/ol.2017.6561