Open Access

Expression and clinical significance of SATB1 and TLR4 in breast cancer

  • Authors:
    • Xuebo Wang
    • Xiumei Yu
    • Qingli Wang
    • Yingying Lu
    • Haixia Chen
  • View Affiliations

  • Published online on: July 12, 2017     https://doi.org/10.3892/ol.2017.6571
  • Pages: 3611-3615
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

This study investigated the expression of special AT‑rich sequence‑binding protein 1 (SATB1) and toll‑like receptor 4 (TLR4) protein in breast cancer and its clinical significance. We collected breast cancer tissues from 120 patients and adjacent non‑cancerous tissue from 53 patients. SATB1 was expressed in 89 cases of breast cancer (74.17%) and in 7 cases of adjacent non‑cancerous tissue (13.21%). TLR4 was expressed in 70 cases of breast cancer tissues (58.33%) and in 48 cases of adjacent non‑cancerous tissue (90.57%). The differences of SATB and TLR4 in breast cancer and adjacent non‑cancerous tissue were statistically significant. We found a negative correlation between the expression of SATB1 and TLR4 (r=‑0.624, P<0.05). The expression of SATB1 and TLR4 were not significantly correlated with age, menopause, and PR and HER‑2 protein expression, but were significantly correlated with tumor size, local lymphatic metastasis, histopathological grade, tumor stage, and ER protein expression (P<0.05). Overall, SATB1 and TLR4 proteins are involved in the development of breast cancer, a finding of great significance to identify therapeutic targets and prognosis markers for breast cancer.
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September-2017
Volume 14 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang X, Yu X, Wang Q, Lu Y and Chen H: Expression and clinical significance of SATB1 and TLR4 in breast cancer. Oncol Lett 14: 3611-3615, 2017
APA
Wang, X., Yu, X., Wang, Q., Lu, Y., & Chen, H. (2017). Expression and clinical significance of SATB1 and TLR4 in breast cancer. Oncology Letters, 14, 3611-3615. https://doi.org/10.3892/ol.2017.6571
MLA
Wang, X., Yu, X., Wang, Q., Lu, Y., Chen, H."Expression and clinical significance of SATB1 and TLR4 in breast cancer". Oncology Letters 14.3 (2017): 3611-3615.
Chicago
Wang, X., Yu, X., Wang, Q., Lu, Y., Chen, H."Expression and clinical significance of SATB1 and TLR4 in breast cancer". Oncology Letters 14, no. 3 (2017): 3611-3615. https://doi.org/10.3892/ol.2017.6571