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Article Open Access

Expression and clinical significance of SATB1 and TLR4 in breast cancer

  • Authors:
    • Xuebo Wang
    • Xiumei Yu
    • Qingli Wang
    • Yingying Lu
    • Haixia Chen
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Yuhuangding Hospital of Yantai, Yantai, Shandong 264000, P.R. China, Department of Cardiology, The People's Hospital of Zhangqiu, Zhangqiu, Shandong 250200, P.R. China, Department of Clinical Laboratory, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China, Department of Clinical Laboratory, Yeda Hospital of Yantai, Yantai, Shandong 264000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3611-3615
    |
    Published online on: July 12, 2017
       https://doi.org/10.3892/ol.2017.6571
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Abstract

This study investigated the expression of special AT‑rich sequence‑binding protein 1 (SATB1) and toll‑like receptor 4 (TLR4) protein in breast cancer and its clinical significance. We collected breast cancer tissues from 120 patients and adjacent non‑cancerous tissue from 53 patients. SATB1 was expressed in 89 cases of breast cancer (74.17%) and in 7 cases of adjacent non‑cancerous tissue (13.21%). TLR4 was expressed in 70 cases of breast cancer tissues (58.33%) and in 48 cases of adjacent non‑cancerous tissue (90.57%). The differences of SATB and TLR4 in breast cancer and adjacent non‑cancerous tissue were statistically significant. We found a negative correlation between the expression of SATB1 and TLR4 (r=‑0.624, P<0.05). The expression of SATB1 and TLR4 were not significantly correlated with age, menopause, and PR and HER‑2 protein expression, but were significantly correlated with tumor size, local lymphatic metastasis, histopathological grade, tumor stage, and ER protein expression (P<0.05). Overall, SATB1 and TLR4 proteins are involved in the development of breast cancer, a finding of great significance to identify therapeutic targets and prognosis markers for breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Yu X, Wang Q, Lu Y and Chen H: Expression and clinical significance of SATB1 and TLR4 in breast cancer. Oncol Lett 14: 3611-3615, 2017.
APA
Wang, X., Yu, X., Wang, Q., Lu, Y., & Chen, H. (2017). Expression and clinical significance of SATB1 and TLR4 in breast cancer. Oncology Letters, 14, 3611-3615. https://doi.org/10.3892/ol.2017.6571
MLA
Wang, X., Yu, X., Wang, Q., Lu, Y., Chen, H."Expression and clinical significance of SATB1 and TLR4 in breast cancer". Oncology Letters 14.3 (2017): 3611-3615.
Chicago
Wang, X., Yu, X., Wang, Q., Lu, Y., Chen, H."Expression and clinical significance of SATB1 and TLR4 in breast cancer". Oncology Letters 14, no. 3 (2017): 3611-3615. https://doi.org/10.3892/ol.2017.6571
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Yu X, Wang Q, Lu Y and Chen H: Expression and clinical significance of SATB1 and TLR4 in breast cancer. Oncol Lett 14: 3611-3615, 2017.
APA
Wang, X., Yu, X., Wang, Q., Lu, Y., & Chen, H. (2017). Expression and clinical significance of SATB1 and TLR4 in breast cancer. Oncology Letters, 14, 3611-3615. https://doi.org/10.3892/ol.2017.6571
MLA
Wang, X., Yu, X., Wang, Q., Lu, Y., Chen, H."Expression and clinical significance of SATB1 and TLR4 in breast cancer". Oncology Letters 14.3 (2017): 3611-3615.
Chicago
Wang, X., Yu, X., Wang, Q., Lu, Y., Chen, H."Expression and clinical significance of SATB1 and TLR4 in breast cancer". Oncology Letters 14, no. 3 (2017): 3611-3615. https://doi.org/10.3892/ol.2017.6571
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