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Case Report

Atypical chronic myeloid leukemia with isochromosome (X)(p10): A case report

  • Authors:
    • Masahide Yamamoto
    • Sayaka Suzuki
    • Jun‑Ichi Mukae
    • Keisuke Tanaka
    • Ken Watanabe
    • Gaku Oshikawa
    • Tetsuya Fukuda
    • Naomi Murakami
    • Osamu Miura
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Tokyo Medical and Dental University, Tokyo 113‑8519, Japan
  • Pages: 3717-3721
    |
    Published online on: July 18, 2017
       https://doi.org/10.3892/ol.2017.6595
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Abstract

Atypical chronic myeloid leukemia (aCML) is a rare subtype of myelodysplastic/myeloproliferative neoplasm (MDS/MPN). Although recurrent chromosomal and genetic abnormalities are frequently observed in aCML, none are specific to this type of leukemia. The present study reported a case of aCML associated with i(X)(p10), a rare recurrent chromosomal abnormality of hematological malignancy. A 40‑year‑old female was referred to the Tokyo Medical and Dental University Hospital (Tokyo, Japan) due to slight leukocytosis and anemia. A bone marrow aspiration revealed 4% blasts and granulocytic hyperplasia with dysplasia. A G‑banded cytogenetic analysis of the bone marrow cells revealed 46, X, isochromosome X(iX)(p10) in all metaphases. The percentage of the neutrophil precursors promyelocytes, myelocytes and metamyelocytes in the peripheral blood was >10% throughout the clinical course of the patient, which resulted in a diagnosis of atypical chronic myeloid leukemia. Treatment with hydroxycarbamide was not able to effectively alleviate leukocytosis, and the disease progressed with the appearance of an additional cytogenetic abnormality, t(10;17)(p13;q21). Subsequently, the patient underwent allogeneic stem cell transplantation from a sibling donor, and subsequent cytogenetic analysis revealed a normal karyotype with full donor chimerism. The isodicentric X(idicX)(q13) mutation is a similar abnormality to i(X)(p10) and may result in a loss of the X‑inactive specific transcript gene located at Xq13.2, the deletion of which has been previously reported to result in the development of MDS/MPN in mice. In addition, i(X)(p10) was identified as the sole chromosomal abnormality at the diagnosis of aCML in the case of the present study, which is similar to patients from previous studies of other hematological malignancies and supports the hypothesis that i(X)(p10) may have served a primary role in the leukemogenesis of aCML.
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Copy and paste a formatted citation
Spandidos Publications style
Yamamoto M, Suzuki S, Mukae JI, Tanaka K, Watanabe K, Oshikawa G, Fukuda T, Murakami N and Miura O: Atypical chronic myeloid leukemia with isochromosome (X)(p10): A case report. Oncol Lett 14: 3717-3721, 2017.
APA
Yamamoto, M., Suzuki, S., Mukae, J., Tanaka, K., Watanabe, K., Oshikawa, G. ... Miura, O. (2017). Atypical chronic myeloid leukemia with isochromosome (X)(p10): A case report. Oncology Letters, 14, 3717-3721. https://doi.org/10.3892/ol.2017.6595
MLA
Yamamoto, M., Suzuki, S., Mukae, J., Tanaka, K., Watanabe, K., Oshikawa, G., Fukuda, T., Murakami, N., Miura, O."Atypical chronic myeloid leukemia with isochromosome (X)(p10): A case report". Oncology Letters 14.3 (2017): 3717-3721.
Chicago
Yamamoto, M., Suzuki, S., Mukae, J., Tanaka, K., Watanabe, K., Oshikawa, G., Fukuda, T., Murakami, N., Miura, O."Atypical chronic myeloid leukemia with isochromosome (X)(p10): A case report". Oncology Letters 14, no. 3 (2017): 3717-3721. https://doi.org/10.3892/ol.2017.6595
Copy and paste a formatted citation
x
Spandidos Publications style
Yamamoto M, Suzuki S, Mukae JI, Tanaka K, Watanabe K, Oshikawa G, Fukuda T, Murakami N and Miura O: Atypical chronic myeloid leukemia with isochromosome (X)(p10): A case report. Oncol Lett 14: 3717-3721, 2017.
APA
Yamamoto, M., Suzuki, S., Mukae, J., Tanaka, K., Watanabe, K., Oshikawa, G. ... Miura, O. (2017). Atypical chronic myeloid leukemia with isochromosome (X)(p10): A case report. Oncology Letters, 14, 3717-3721. https://doi.org/10.3892/ol.2017.6595
MLA
Yamamoto, M., Suzuki, S., Mukae, J., Tanaka, K., Watanabe, K., Oshikawa, G., Fukuda, T., Murakami, N., Miura, O."Atypical chronic myeloid leukemia with isochromosome (X)(p10): A case report". Oncology Letters 14.3 (2017): 3717-3721.
Chicago
Yamamoto, M., Suzuki, S., Mukae, J., Tanaka, K., Watanabe, K., Oshikawa, G., Fukuda, T., Murakami, N., Miura, O."Atypical chronic myeloid leukemia with isochromosome (X)(p10): A case report". Oncology Letters 14, no. 3 (2017): 3717-3721. https://doi.org/10.3892/ol.2017.6595
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