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Article

MicroRNA‑552 promotes tumor cell proliferation and migration by directly targeting DACH1 via the Wnt/β‑catenin signaling pathway in colorectal cancer

  • Authors:
    • Jia Cao
    • Xiu‑Rui Yan
    • Ting Liu
    • Xue‑Bo Han
    • Jing‑Jing Yu
    • Shi‑Hai Liu
    • Li‑Bin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Medical Laboratory, Ningxia Medical University, Clinical Medicine College, Yinchuan, Ningxia 750004, P.R. China, Stem Cell Institute, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China, Central Laboratory, The Affiliated Hospital of Qingdao University, Animal Experimental Center, Qingdao, Shandong 266003, P.R. China
  • Pages: 3795-3802
    |
    Published online on: July 18, 2017
       https://doi.org/10.3892/ol.2017.6600
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Abstract

The purpose of the present study was to analyze the crucial role of microRNAs (miRNAs/miRs) involved in the proliferation and migration of colorectal cancer (CRC) and to investigate their underlying mechanisms. The present study discusses the expression and function of miR‑552 in CRC. The expression level of miR‑552 in CRC cells and tissues was observed, and it was suggested that the high expression of miR‑552 accelerated the proliferation and migration of CRC cells in vitro. Notably, a result of the present study was that the cell fate determination factor Dachshund family transcription factor 1 (DACH1) was identified as a direct target of miR‑552. Suppressing miR‑552 expression in CRC cells increased endogenous DACH1 mRNA and protein levels, which was negatively correlated with miR‑552. DACH1 performs an important role in the development of a number of neoplasms, and has the ability to regulate the Wnt/β‑catenin signaling pathway as a novel predictive and diagnostic biomarker. Accordingly, it was concluded that miR‑552 exerted a tumor‑promoting role in CRC development by targeting DACH1, which may contribute to the increase in the rates of CRC proliferation and migration. miR‑552 may serve as a potential diagnostic and prognostic biomarker for CRC.
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1 

Chen MB, Wei MX, Han JY, Wu XY, Li C, Wang J, Shen W and Lu PH: MicroRNA-451 regulates AMPK/mTORC1 signaling and fascin1 expression in HT-29 colorectal cancer. Cell Signal. 26:102–109. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Dong Y, Yu J and Ng SS: MicroRNA dysregulation as a prognostic biomarker in colorectal cancer. Cancer Manag Res. 6:405–422. 2014.PubMed/NCBI

3 

Gellad ZF and Provenzale D: Colorectal cancer: National and international perspective on the burden of disease and public health impact. Gastroenterology. 138:2177–2190. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Cristóbal I, Caramés C, Madoz-Gúrpide J, Rojo F, Aguilera O and García-Foncillas J: Downregulation of miR-214 is specific of liver metastasis in colorectal cancer and could play a role determining the metastatic niche. Int J Colorectal Dis. 29:8852014. View Article : Google Scholar : PubMed/NCBI

5 

Bonfrate L, Altomare DF, Di Lena M, Travaglio E, Rotelli MT, De Luca A and Portincasa P: MicroRNA in colorectal cancer: New perspectives for diagnosis, prognosis and treatment. J Gastrointestin Liver Dis. 22:311–320. 2013.PubMed/NCBI

6 

Giordano S and Columbano A: MicroRNAs: New tools for diagnosis, prognosis, and therapy in hepatocellular carcinoma? Hepatology. 57:840–847. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Hur K, Toiyama Y, Okugawa Y, Ide S, Imaoka H, Boland CR and Goel A: Circulating microRNA-203 predicts prognosis and metastasis in human colorectal cancer. Gut. 66:654–665. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Croce CM: Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet. 10:704–714. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Bai R, Weng C, Dong H, Li S, Chen G and Xu Z: MicroRNA-409-3p suppresses colorectal cancer invasion and metastasis partly by targeting GAB1 expression. Int J Cancer. 137:2310–2322. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Jinushi T, Shibayama Y, Kinoshita I, Oizumi S, Jinushi M, Aota T, Takahashi T, Horita S, Dosaka-Akita H and Iseki K: Low expression levels of microRNA-124-5p correlated with poor prognosis in colorectal cancer via targeting of SMC4. Cancer Med. 3:1544–1552. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Rokavec M, Öner MG, Li H, Jackstadt R, Jiang L, Lodygin D, Kaller M, Horst D, Ziegler PK, Schwitalla S, et al: IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J Clin Invest. 124:1853–1867. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Qiu Z, Guo W, Wang Q, Chen Z, Huang S, Zhao F, Yao M, Zhao Y and He X: MicroRNA-124 reduces the pentose phosphate pathway and proliferation by targeting PRPS1 and RPIA mRNAs in human colorectal cancer cells. Gastroenterology. 149:1587–1598, e11. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Hwang WL, Jiang JK, Yang SH, Huang TS, Lan HY, Teng HW, Yang CY, Tsai YP, Lin CH, Wang HW and Yang MH: MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells. Nat Cell Biol. 16:268–280. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Zhang X, Schulz R, Edmunds S, Krüger E, Markert E, Gaedcke J, Cormet-Boyaka E, Ghadimi M, Beissbarth T, Levine AJ, et al: MicroRNA-101 suppresses tumor cell proliferation by acting as an endogenous proteasome inhibitor via targeting the proteasome assembly factor POMP. Mol Cell. 59:243–257. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Slaby O, Svoboda M, Michalek J and Vyzula R: MicroRNAs in colorectal cancer: Translation of molecular biology into clinical application. Mol Cancer. 8:1022009. View Article : Google Scholar : PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Della Vittoria Scarpati G, Calura E, Di Marino M, Romualdi C, Beltrame L, Malapelle U, Troncone G, De Stefano A, Pepe S, De Placido S, et al: Analysis of differential miRNA expression in primary tumor and stroma of colorectal cancer patients. Biomed Res Int. 2014:8409212014.PubMed/NCBI

18 

Betel D, Wilson M, Gabow A, Marks DS and Sander C: The microRNA.org resource: Targets and expression. Nucleic Acids Res. 36:D149–D153. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Yan W, Wu K, Herman JG, Brock MV, Fuks F, Yang L, Zhu H, Li Y, Yang Y and Guo M: Epigenetic regulation of DACH1, a novel Wnt signaling component in colorectal cancer. Epigenetics. 8:1373–1383. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Liu Y, Zhou R, Yuan X, Han N, Zhou S, Xu H, Guo M, Yu S, Zhang C, Yin T and Wu K: DACH1 is a novel predictive and prognostic biomarker in hepatocellular carcinoma as a negative regulator of Wnt/β-catenin signaling. Oncotarget. 6:8621–8634. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Amirkhah R, Schmitz U, Linnebacher M, Wolkenhauer O and Farazmand A: MicroRNA-mRNA interactions in colorectal cancer and their role in tumor progression. Genes Chromosomes Cancer. 54:129–141. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Shen G, Rong X, Zhao J, Yang X, Li H, Jiang H, Zhou Q, Ji T, Huang S, Zhang J and Jia H: MicroRNA-105 suppresses cell proliferation and inhibits PI3K/AKT signaling in human hepatocellular carcinoma. Carcinogenesis. 35:2748–2755. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Kim J, Lim NJ, Jang SG, Kim HK and Lee GK: miR-592 and miR-552 can distinguish between primary lung adenocarcinoma and colorectal cancer metastases in the lung. Anticancer Res. 34:2297–2302. 2014.PubMed/NCBI

24 

Xia ZS, Wang L, Yu T, Zhong W, Lian GD, Wu D, Zhou HM and Chen GC: MiR-5000-3p, miR-5009-3P and miR-552: Potential microRNA biomarkers of side population cells in colon cancer. Oncol Rep. 32:589–596. 2014.PubMed/NCBI

25 

Atkins M, Jiang Y, Sansores-Garcia L, Jusiak B, Halder G and Mardon G: Dynamic rewiring of the Drosophila retinal determination network switches its function from selector to differentiation. PLoS Genet. 9:e10037312013. View Article : Google Scholar : PubMed/NCBI

26 

Wang P: Suppression of DACH1 promotes migration and invasion of colorectal cancer via activating TGF-β-mediated epithelial-mesenchymal transition. Biochem Biophys Res Commun. 460:314–319. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Chu Q, Han N, Yuan X, Nie X, Wu H, Chen Y, Guo M, Yu S and Wu K: DACH1 inhibits cyclin D1 expression, cellular proliferation and tumor growth of renal cancer cells. J Hematol Oncol. 7:732014. View Article : Google Scholar : PubMed/NCBI

28 

Mohammed MK, Shao C, Wang J, Wei Q, Wang X, Collier Z, Tang S, Liu H, Zhang F, Huang J, et al: Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance. Genes Dis. 3:11–40. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cao J, Yan XR, Liu T, Han XB, Yu JJ, Liu SH and Wang LB: MicroRNA‑552 promotes tumor cell proliferation and migration by directly targeting DACH1 via the Wnt/β‑catenin signaling pathway in colorectal cancer. Oncol Lett 14: 3795-3802, 2017.
APA
Cao, J., Yan, X., Liu, T., Han, X., Yu, J., Liu, S., & Wang, L. (2017). MicroRNA‑552 promotes tumor cell proliferation and migration by directly targeting DACH1 via the Wnt/β‑catenin signaling pathway in colorectal cancer. Oncology Letters, 14, 3795-3802. https://doi.org/10.3892/ol.2017.6600
MLA
Cao, J., Yan, X., Liu, T., Han, X., Yu, J., Liu, S., Wang, L."MicroRNA‑552 promotes tumor cell proliferation and migration by directly targeting DACH1 via the Wnt/β‑catenin signaling pathway in colorectal cancer". Oncology Letters 14.3 (2017): 3795-3802.
Chicago
Cao, J., Yan, X., Liu, T., Han, X., Yu, J., Liu, S., Wang, L."MicroRNA‑552 promotes tumor cell proliferation and migration by directly targeting DACH1 via the Wnt/β‑catenin signaling pathway in colorectal cancer". Oncology Letters 14, no. 3 (2017): 3795-3802. https://doi.org/10.3892/ol.2017.6600
Copy and paste a formatted citation
x
Spandidos Publications style
Cao J, Yan XR, Liu T, Han XB, Yu JJ, Liu SH and Wang LB: MicroRNA‑552 promotes tumor cell proliferation and migration by directly targeting DACH1 via the Wnt/β‑catenin signaling pathway in colorectal cancer. Oncol Lett 14: 3795-3802, 2017.
APA
Cao, J., Yan, X., Liu, T., Han, X., Yu, J., Liu, S., & Wang, L. (2017). MicroRNA‑552 promotes tumor cell proliferation and migration by directly targeting DACH1 via the Wnt/β‑catenin signaling pathway in colorectal cancer. Oncology Letters, 14, 3795-3802. https://doi.org/10.3892/ol.2017.6600
MLA
Cao, J., Yan, X., Liu, T., Han, X., Yu, J., Liu, S., Wang, L."MicroRNA‑552 promotes tumor cell proliferation and migration by directly targeting DACH1 via the Wnt/β‑catenin signaling pathway in colorectal cancer". Oncology Letters 14.3 (2017): 3795-3802.
Chicago
Cao, J., Yan, X., Liu, T., Han, X., Yu, J., Liu, S., Wang, L."MicroRNA‑552 promotes tumor cell proliferation and migration by directly targeting DACH1 via the Wnt/β‑catenin signaling pathway in colorectal cancer". Oncology Letters 14, no. 3 (2017): 3795-3802. https://doi.org/10.3892/ol.2017.6600
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