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Article Open Access

Clinical and biological effects of tumor‑associated lymphocytes in the presence or absence of chemotherapy for malignant ascites in ovarian cancer patients

Corrigendum in: /10.3892/ol.2018.8537
  • Authors:
    • Weiwei Zhang
    • Kejun Liu
    • Bin Ye
    • Guolin Hu
    • Kelei Zhao
    • Yazhou Ren
    • Weijiang Liang
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, The Sixth People's Hospital of Chengdu, Chengdu, Sichuan 610051, P.R. China, Department of Medical Oncology, Dongguan People's Hospital, Dongguan, Guangdong 523059, P.R. China, Department of Medical Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Big Data Research Center, School of Computer Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 611731, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3379-3386
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    Published online on: July 20, 2017
       https://doi.org/10.3892/ol.2017.6635
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Abstract

Tumor‑associated lymphocytes (TALs) have been successfully isolated from ascites and solid tumors, however the clinical use of TALs in treating ovarian cancer (OC) has not yet been reported. The present study investigated the efficacy and toxicity of TALs in the presence or absence of chemotherapy in OC patients with malignant ascites (MA). A total of 32 patients were enrolled in this study. A total of 8 patients received treatment with TALs alone (TALs group), 11 patients received combined treatment of TALs and chemotherapy (combination group) and 13 patients received chemotherapy alone (chemotherapy group). The endpoints included Karnofsky performance status (KPS), ascites‑associated symptoms (AAS), time to progression (TTP) and overall survival (OS). Compared with the TALs and chemotherapy group, the KPS and AAS in the combination group significantly improved following treatment. Patients in the TALs group (37.5%) and chemotherapy group (53.8%) achieved significantly fewer objective response rates of ascites compared with those in the combination group (90.9%). Furthermore, combination therapy significantly extended TTP (13 months) compared with TALs alone (1 month, P<0.001), and chemotherapy alone (6 months, P=0.027). Similar results were observed for OS between the combination group and the TALs group (25 vs. 7 months, P<0.001). The present study therefore demonstrates that combined therapy of TALs and chemotherapy is safe, feasible, and more effective than chemotherapy or TALs alone in controlling MA and improving the quality of life for OC patients.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang W, Liu K, Ye B, Hu G, Zhao K, Ren Y and Liang W: Clinical and biological effects of tumor‑associated lymphocytes in the presence or absence of chemotherapy for malignant ascites in ovarian cancer patients Corrigendum in /10.3892/ol.2018.8537. Oncol Lett 14: 3379-3386, 2017.
APA
Zhang, W., Liu, K., Ye, B., Hu, G., Zhao, K., Ren, Y., & Liang, W. (2017). Clinical and biological effects of tumor‑associated lymphocytes in the presence or absence of chemotherapy for malignant ascites in ovarian cancer patients Corrigendum in /10.3892/ol.2018.8537. Oncology Letters, 14, 3379-3386. https://doi.org/10.3892/ol.2017.6635
MLA
Zhang, W., Liu, K., Ye, B., Hu, G., Zhao, K., Ren, Y., Liang, W."Clinical and biological effects of tumor‑associated lymphocytes in the presence or absence of chemotherapy for malignant ascites in ovarian cancer patients Corrigendum in /10.3892/ol.2018.8537". Oncology Letters 14.3 (2017): 3379-3386.
Chicago
Zhang, W., Liu, K., Ye, B., Hu, G., Zhao, K., Ren, Y., Liang, W."Clinical and biological effects of tumor‑associated lymphocytes in the presence or absence of chemotherapy for malignant ascites in ovarian cancer patients Corrigendum in /10.3892/ol.2018.8537". Oncology Letters 14, no. 3 (2017): 3379-3386. https://doi.org/10.3892/ol.2017.6635
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang W, Liu K, Ye B, Hu G, Zhao K, Ren Y and Liang W: Clinical and biological effects of tumor‑associated lymphocytes in the presence or absence of chemotherapy for malignant ascites in ovarian cancer patients Corrigendum in /10.3892/ol.2018.8537. Oncol Lett 14: 3379-3386, 2017.
APA
Zhang, W., Liu, K., Ye, B., Hu, G., Zhao, K., Ren, Y., & Liang, W. (2017). Clinical and biological effects of tumor‑associated lymphocytes in the presence or absence of chemotherapy for malignant ascites in ovarian cancer patients Corrigendum in /10.3892/ol.2018.8537. Oncology Letters, 14, 3379-3386. https://doi.org/10.3892/ol.2017.6635
MLA
Zhang, W., Liu, K., Ye, B., Hu, G., Zhao, K., Ren, Y., Liang, W."Clinical and biological effects of tumor‑associated lymphocytes in the presence or absence of chemotherapy for malignant ascites in ovarian cancer patients Corrigendum in /10.3892/ol.2018.8537". Oncology Letters 14.3 (2017): 3379-3386.
Chicago
Zhang, W., Liu, K., Ye, B., Hu, G., Zhao, K., Ren, Y., Liang, W."Clinical and biological effects of tumor‑associated lymphocytes in the presence or absence of chemotherapy for malignant ascites in ovarian cancer patients Corrigendum in /10.3892/ol.2018.8537". Oncology Letters 14, no. 3 (2017): 3379-3386. https://doi.org/10.3892/ol.2017.6635
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