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Leiomyosarcoma of the inferior vena cava: Survival rate following radical resection

  • Authors:
    • Frederico José Ribeiro Teixeira
    • Sergio Dias do Couto Netto
    • André Luis de Freitas Perina
    • Fabio C. M. Torricelli
    • Luciana Ragazzo Teixeira
    • Antonio Eduardo Zerati
    • Fabio de Oliveira Ferreira
    • Eduardo Hiroshi Akaishi
    • William Carlos Nahas
    • Edivaldo Massazo Utiyama
  • View Affiliations / Copyright

    Affiliations: Sarcoma and Melanoma Surgery Unit, São Paulo Cancer Institute, University of São Paulo Medical School, Cerqueira César, SP 05403‑000, Brazil, Department of General Surgery, Clinics Hospital, University of São Paulo Medical School, Cerqueira César, SP 05403‑000, Brazil, Department of Urology, Clinics Hospital, University of São Paulo Medical School, Cerqueira César, SP 05403‑000, Brazil, Department of Vascular Surgery, Clinics Hospital, University of São Paulo Medical School, Cerqueira César, SP 05403‑000, Brazil
    Copyright: © Teixeira et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3909-3916
    |
    Published online on: August 2, 2017
       https://doi.org/10.3892/ol.2017.6706
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Abstract

Leiomyosarcoma (LMS) of inferior vena cava (IVC) is a rare neoplasm affecting approximately 1/100,000 people. The prognosis is poor and potential curative intent occurs through challenging operations, such as vena cava resection, occasionally multivisceral when required, and vascular reconstruction. There are few retrospective series regarding this retroperitoneal neoplasm, and the aim of the present study was to discuss the experience at the São Paulo Cancer Institute and Clinics Hospital of University of São Paulo Medical School, São Paulo, Brazil. The current study is a retrospective review of 7 patients treated in the two tertiary hospitals between 2005 and 2013. Oncological and operative aspects were discussed, primarily regarding surgical aspects highlighting en bloc resection, vascular reconstruction, and the overall survival and recurrence rates. All the patients were treated with radical intent, 4 of whom underwent multivisceral resection, with the kidney being the most resected organ. The location of the IVC tumor was described using Kulaylat's description and the median tumor size was 10 cm. Vascular reconstruction was necessary in 4 patients. The overall survival rate at 3 and 5 years was 100, and 25%, respectively. The disease‑free survival rate at 3 and 5 years was 57 and 20%, respectively. In conclusion, IVC LMS is a rare and severe retroperitoneal neoplasm, with multivisceral resections remaining a surgical challenge. The treatment requires numerous experienced surgeons and the impact of microscopic free margins remains unclear. Vascular reconstruction depends on several aspects regarding primarily the topography of the tumor.
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Copy and paste a formatted citation
Spandidos Publications style
Teixeira FJ, do Couto Netto SD, Perina AL, Torricelli FC, Ragazzo Teixeira L, Zerati AE, Ferreira Fd, Akaishi EH, Nahas WC, Utiyama EM, Utiyama EM, et al: Leiomyosarcoma of the inferior vena cava: Survival rate following radical resection. Oncol Lett 14: 3909-3916, 2017.
APA
Teixeira, F.J., do Couto Netto, S.D., Perina, A.L., Torricelli, F.C., Ragazzo Teixeira, L., Zerati, A.E. ... Utiyama, E.M. (2017). Leiomyosarcoma of the inferior vena cava: Survival rate following radical resection. Oncology Letters, 14, 3909-3916. https://doi.org/10.3892/ol.2017.6706
MLA
Teixeira, F. J., do Couto Netto, S. D., Perina, A. L., Torricelli, F. C., Ragazzo Teixeira, L., Zerati, A. E., Ferreira, F. d., Akaishi, E. H., Nahas, W. C., Utiyama, E. M."Leiomyosarcoma of the inferior vena cava: Survival rate following radical resection". Oncology Letters 14.4 (2017): 3909-3916.
Chicago
Teixeira, F. J., do Couto Netto, S. D., Perina, A. L., Torricelli, F. C., Ragazzo Teixeira, L., Zerati, A. E., Ferreira, F. d., Akaishi, E. H., Nahas, W. C., Utiyama, E. M."Leiomyosarcoma of the inferior vena cava: Survival rate following radical resection". Oncology Letters 14, no. 4 (2017): 3909-3916. https://doi.org/10.3892/ol.2017.6706
Copy and paste a formatted citation
x
Spandidos Publications style
Teixeira FJ, do Couto Netto SD, Perina AL, Torricelli FC, Ragazzo Teixeira L, Zerati AE, Ferreira Fd, Akaishi EH, Nahas WC, Utiyama EM, Utiyama EM, et al: Leiomyosarcoma of the inferior vena cava: Survival rate following radical resection. Oncol Lett 14: 3909-3916, 2017.
APA
Teixeira, F.J., do Couto Netto, S.D., Perina, A.L., Torricelli, F.C., Ragazzo Teixeira, L., Zerati, A.E. ... Utiyama, E.M. (2017). Leiomyosarcoma of the inferior vena cava: Survival rate following radical resection. Oncology Letters, 14, 3909-3916. https://doi.org/10.3892/ol.2017.6706
MLA
Teixeira, F. J., do Couto Netto, S. D., Perina, A. L., Torricelli, F. C., Ragazzo Teixeira, L., Zerati, A. E., Ferreira, F. d., Akaishi, E. H., Nahas, W. C., Utiyama, E. M."Leiomyosarcoma of the inferior vena cava: Survival rate following radical resection". Oncology Letters 14.4 (2017): 3909-3916.
Chicago
Teixeira, F. J., do Couto Netto, S. D., Perina, A. L., Torricelli, F. C., Ragazzo Teixeira, L., Zerati, A. E., Ferreira, F. d., Akaishi, E. H., Nahas, W. C., Utiyama, E. M."Leiomyosarcoma of the inferior vena cava: Survival rate following radical resection". Oncology Letters 14, no. 4 (2017): 3909-3916. https://doi.org/10.3892/ol.2017.6706
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