Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2017 Volume 14 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2017 Volume 14 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

NHE1 has a notable role in metastasis and drug resistance of T-cell acute lymphoblastic leukemia

  • Authors:
    • Ehtisham Altaf
    • Xiaoxing Huang
    • Jie Xiong
    • Xiangyong Yang
    • Xinzhou Deng
    • Meng Xiong
    • Lu Zhou
    • Shan Pan
    • Wen Yuan
    • Xinran Li
    • Ling Hao
    • Kingsley Miyanda Tembo
    • Ruijing Xiao
    • Qiuping Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Bioengineering, Hubei University of Technology Engineering and Technology College, Wuhan, Hubei 430068, P.R. China, Department of Hematology, Taihe Hospital, Shiyan, Hubei 442000, P.R. China
  • Pages: 4256-4262
    |
    Published online on: August 3, 2017
       https://doi.org/10.3892/ol.2017.6716
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

T-cell acute lymphoblastic leukemia (T-ALL) represents a spectrum of hematological malignancies that affect human health. Metastasis and chemotherapeutic drug resistance are the primary causes of mortality in patients with T‑ALL. Sodium‑hydrogen antiporter 1 (NHE1) is established to serve a role in metastasis and drug resistance in numerous types of cancer; however, the function of NHE1 in T‑ALL remains to be elucidated. Previously, the C‑C‑motif chemokine ligand 25 (CCL25) was identified to be involved in metastasis and drug resistance in the MOLT4 T‑ALL cell line, as was the ezrin protein. The present study investigated the role of NHE1 in the metastasis of T‑ALL using a Transwell assay and scanning electron microscopy, using MOLT4 cells as a model. The association between NHE1 and ezrin was assessed using laser scanning confocal microscopy. The effect of NHE1 on resistance to the chemotherapy drug doxorubicin (DOX) was also investigated using a cell viability and cytotoxicity assay. Expression of NHE1 increased following treatment with CCL25, accompanied by morphological changes in MOLT4 cells and the co‑localization of NHE1 with ezrin. In addition, wild‑type MOLT4 cells exhibited an increased polarization ability compared with NHE1‑ or ezrin‑silenced cells. NHE1‑ or ezrin‑silenced cells exhibited higher sensitivity to DOX compared with wild‑type MOLT4 cells. In conclusion, the increased expression or activity of NHE1 may potentially be a poor prognostic indicator for human T‑ALL.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Gómez AM, Martínez C, González M, Luque A, Melen GJ, Martínez J, Hortelano S, Lassaletta Á, Madero L and Ramírez M: Chemokines and relapses in childhood acute lymphoblastic leukemia: A role in migration and in resistance to antileukemic drugs. Blood Cells Mol Dis. 55:220–227. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Pitt LA, Tikhonova AN, Hu H, Trimarchi T, King B, Gong Y, Sanchez-Martin M, Tsirigos A, Littman DR, Ferrando AA, et al: CXCL12-producing vascular endothelial niches control acute T cell leukemia maintenance. Cancer Cell. 27:755–768. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Man CH, Lam SS, Sun MK, Chow HC, Gill H, Kwong YL and Leung AY: A novel tescalcin-sodium/hydrogen exchange axis underlying sorafenib resistance in FLT3-ITD+ AML. Blood. 123:2530–2539. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Amith SR and Fliegel L: Regulation of the Na+/H+ exchanger (NHE1) in breast cancer metastasis. Cancer Res. 73:1259–1264. 2013.
Slepkov ER, Rainey JK, Li X, Liu Y, Cheng FJ, Lindhout DA, Sykes BD and Fliegel L: Structural and functional characterization of transmembrane segment IV of the NHE1 isoform of the Na+/H+ exchanger. J Biol Chem 280: 17863–17872, 2005. View Article : Google Scholar : PubMed/NCBI

5 

Orlowski J and Grinstein S: Diversity of the mammalian sodium/proton exchanger SLC9 gene family. Pflugers Arch. 447:549–565. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Antelmi E, Cardone RA, Greco MR, Rubino R, Di Sole F, Martino NA, Casavola V, Carcangiu M, Moro L and Reshkin SJ: ß1 integrin binding phosphorylates ezrin at T567 to activate a lipid raft signalsome driving invadopodia activity and invasion. PLoS One. 8:e751132013. View Article : Google Scholar : PubMed/NCBI

7 

Lin Y, Wang J, Jin W, Wang L, Li H, Ma L, Li Q and Pang T: NHE1 mediates migration and invasion of HeLa cells via regulating the expression and localization of MT1-MMP. Cell Biochem Funct. 30:41–46. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Denker SP, Huang DC, Orlowski J, Furthmayr H and Barber DL: Direct binding of the Na-H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation. Mol Cell. 6:1425–1436. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Chiang Y, Chou CY, Hsu KF, Huang YF and Shen MR: EGF upregulates Na+/H+ exchanger NHE1 by post-translational regulation that is important for cervical cancer cell invasiveness. J Cell Physiol. 214:810–819. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Cong D, Zhu W, Shi Y, Pointer KB, Clark PA, Shen H, Kuo JS, Hu S and Sun D: Upregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H+ extrusion, cell migration and survival. Carcinogenesis. 35:2014–2024. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Zhou B, Leng J, Hu M, Zhang L, Wang Z, Liu D, Tong X, Yu B, Hu Y, Deng C, et al: Ezrin is a key molecule in the metastasis of MOLT4 cells induced by CCL25/CCR9. Leuk Res. 34:769–776. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Song X, Yang J, Hirbawi J, Ye S, Perera HD, Goksoy E, Dwivedi P, Plow EF, Zhang R and Qin J: A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion. Cell Res. 22:1533–1545. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Chen Y, Wang D, Guo Z, Zhao J, Wu B, Deng H, Zhou T, Xiang H, Gao F, Yu X, et al: Rho kinase phosphorylation promotes Ezrin-mediated metastasis in hepatocellular carcinoma. Cancer Res. 71:1721–1729. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Brambilla D, Zamboni S, Federici C, Lugini L, Lozupone F, De Milito A, Cecchetti S, Cianfriglia M and Fais S: P-glycoprotein binds to ezrin at amino acid residues 149–242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma. Int J Cancer. 130:2824–2834. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Zhang L, Xiao R, Xiong J, Leng J, Ehtisham A, Hu Y, Ding Q, Xu H, Liu S, Wang J, et al: Activated ERM protein plays a critical role in drug resistance of MOLT4 cells induced by CCL25. PLoS One. 1:e523842013. View Article : Google Scholar

16 

Ziętara N, Łyszkiewicz M, Puchałka J, Witzlau K, Reinhardt A, Förster R, Pabst O, Prinz I and Krueger A: Multicongenic fate mapping quantification of dynamics of thymus colonization. J Exp Med. 212:1589–1601. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Zlotoff DA, Sambandam A, Logan TD, Bell JJ, Schwarz BA and Bhandoola A: CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus. Blood. 115:1897–1905. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Qiuping Z, Jei X, Youxin J, Wei J, Chun L, Jin W, Qun W, Yan L, Chunsong H, Mingzhen Y, et al: CC chemokine ligand 25 enhances resistance to apoptosis in CD4+ T cells from patients with T-cell lineage acute and chronic lymphocytic leukemia by means of livin activation. Cancer Res. 64:7579–7587. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Jin W, Li Q, Lin Y, Lu Y, Li H, Wang L, Hu R, Ma L, Wang J and Pang T: Reversal of Imatinib resistance in BCR-ABL-positive leukemia after inhibition of the Na+/H+ exchanger. Cancer Lett. 308:81–90. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Bourgeois S, Meer LV, Wootla B, Bloch-Faure M, Chambrey R, Shull GE, Gawenis LR and Houillier P: NHE4 is critical for the renal handling of ammonia in rodents. J Clin Invest. 120:1895–1904. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Chen CH, Chen TH, Wu MY, Chen JR, Tsai HF, Hong LY, Zheng CM, Chiu IJ, Lin YF and Hsu YH: Peroxisome proliferator-activated receptor alpha protects renal tubular cells from gentamicin-induced apoptosis via upregulating Na+/H+ exchanger NHE1. Mol Med. Nov 23–2015.(Epub ahead of print). View Article : Google Scholar

22 

Hojo T: Specimen preparation of the human cerebellar cortex for scanning electron microscopy using a t-butyl alcohol freeze-drying device. Scanning Microsc Suppl. 10:345–348. 1996.PubMed/NCBI

23 

Deng X, Tu Z, Xiong M, Tembo K, Zhou L, Liu P, Pan S, Xiong J, Yang X, Leng J, et al: Wnt5a and CCL25 promote adult T-cell acute lymphoblastic leukemia cell migration, invasion and metastasis. Oncotarget. 8:39033–39047. 2017.PubMed/NCBI

24 

Dang I, Gorelik R, Sousa-Blin C, Derivery E, Guérin C, Linkner J, Nemethova M, Dumortier JG, Giger FA, Chipysheva TA, et al: Inhibitory signalling to the Arp2/3 complex steers cell migration. Nature. 503:281–284. 2013.PubMed/NCBI

25 

Girardi T, Vicente C, Cools J and De Keersmaecker K: The genetics and molecular biology of T-ALL. Blood. 129:1113–1123. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Tsukasaki K and Tobinai K: Human T-cell lymphotropic virus type I-associated adult T-cell leukemia-lymphoma: New directions in clinical research. Clin Cancer Res. 20:5217–5225. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Beldjord K, Chevret S, Asnafi V, Huguet F, Boulland ML, Leguay T, Thomas X, Cayuela JM, Grardel N, Chalandon Y, et al: Oncogenetics and minimal residual disease are independent outcome predictors in adult patients with acute lymphoblastic leukemia. Blood. 123:3739–3749. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Fehon RG, McClatchey AI and Bretscher A: Organizing the cell cortex: The role of ERM proteins. Nat Rev Mol Cell Biol. 11:276–287. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Babich V and Di Sole F: The Na+/H+ exchanger-3 (NHE3) activity requires ezrin binding to phosphoinositide and its phosphorylation. PLoS One. 10:e01293062015. View Article : Google Scholar : PubMed/NCBI

30 

Yang X, Wang D, Dong W, Song Z and Dou K: Over-expression of Na+/H+ exchanger 1 and its clinicopathologic significance in hepatocellular carcinoma. Med Oncol. 27:1109–1113. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Yang X, Wang D, Dong W, Song Z and Dou K: Inhibition of Na(+)/H(+) exchanger 1 by 5-(N-ethyl-N-isopropyl) amiloride reduces hypoxia-induced hepatocellular carcinoma invasion and motility. Cancer Lett. 295:198–204. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Hoskin V, Szeto A, Ghaffari A, Greer PA, Côté GP and Elliott BE: Ezrin regulates focal adhesion and invadopodia dynamics by altering calpain activity to promote breast cancer cell invasion. Mol Biol Cell. 26:3464–3479. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Altaf E, Huang X, Xiong J, Yang X, Deng X, Xiong M, Zhou L, Pan S, Yuan W, Li X, Li X, et al: NHE1 has a notable role in metastasis and drug resistance of T-cell acute lymphoblastic leukemia. Oncol Lett 14: 4256-4262, 2017.
APA
Altaf, E., Huang, X., Xiong, J., Yang, X., Deng, X., Xiong, M. ... Zhang, Q. (2017). NHE1 has a notable role in metastasis and drug resistance of T-cell acute lymphoblastic leukemia. Oncology Letters, 14, 4256-4262. https://doi.org/10.3892/ol.2017.6716
MLA
Altaf, E., Huang, X., Xiong, J., Yang, X., Deng, X., Xiong, M., Zhou, L., Pan, S., Yuan, W., Li, X., Hao, L., Tembo, K. M., Xiao, R., Zhang, Q."NHE1 has a notable role in metastasis and drug resistance of T-cell acute lymphoblastic leukemia". Oncology Letters 14.4 (2017): 4256-4262.
Chicago
Altaf, E., Huang, X., Xiong, J., Yang, X., Deng, X., Xiong, M., Zhou, L., Pan, S., Yuan, W., Li, X., Hao, L., Tembo, K. M., Xiao, R., Zhang, Q."NHE1 has a notable role in metastasis and drug resistance of T-cell acute lymphoblastic leukemia". Oncology Letters 14, no. 4 (2017): 4256-4262. https://doi.org/10.3892/ol.2017.6716
Copy and paste a formatted citation
x
Spandidos Publications style
Altaf E, Huang X, Xiong J, Yang X, Deng X, Xiong M, Zhou L, Pan S, Yuan W, Li X, Li X, et al: NHE1 has a notable role in metastasis and drug resistance of T-cell acute lymphoblastic leukemia. Oncol Lett 14: 4256-4262, 2017.
APA
Altaf, E., Huang, X., Xiong, J., Yang, X., Deng, X., Xiong, M. ... Zhang, Q. (2017). NHE1 has a notable role in metastasis and drug resistance of T-cell acute lymphoblastic leukemia. Oncology Letters, 14, 4256-4262. https://doi.org/10.3892/ol.2017.6716
MLA
Altaf, E., Huang, X., Xiong, J., Yang, X., Deng, X., Xiong, M., Zhou, L., Pan, S., Yuan, W., Li, X., Hao, L., Tembo, K. M., Xiao, R., Zhang, Q."NHE1 has a notable role in metastasis and drug resistance of T-cell acute lymphoblastic leukemia". Oncology Letters 14.4 (2017): 4256-4262.
Chicago
Altaf, E., Huang, X., Xiong, J., Yang, X., Deng, X., Xiong, M., Zhou, L., Pan, S., Yuan, W., Li, X., Hao, L., Tembo, K. M., Xiao, R., Zhang, Q."NHE1 has a notable role in metastasis and drug resistance of T-cell acute lymphoblastic leukemia". Oncology Letters 14, no. 4 (2017): 4256-4262. https://doi.org/10.3892/ol.2017.6716
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team