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Decreased expression of long non‑coding RNA LOC728290 in human hepatocellular carcinoma

  • Authors:
    • Shao‑Geng Zhang
    • Yu‑Feng Li
    • Na‑Na Zhao
    • Cheng‑Cai Lai
    • Si‑Jie Cheng
    • Jin Yan
    • Peirui Zhang
    • Zhaohai Wang
    • Xi‑Liang Wang
    • Peng‑Hui Yang
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary, 302 Military Hospital of China, Beijing 100039, P.R. China, Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, P.R. China, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4551-4556
    |
    Published online on: August 18, 2017
       https://doi.org/10.3892/ol.2017.6776
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Abstract

Hepatocellular carcinoma (HCC) is a leading cause of cancer‑associated mortality worldwide. Despite progress in the diagnosis and treatment of HCC, prognosis remains unfavorable. Long non‑coding RNAs (lncRNAs) are emerging as important factors in tumorigenesis and cancer progression; however, the underlying molecular mechanisms and clinical significance of lncRNAs in HCC remain largely unknown. The present study examined the expression pattern and clinical significance of a novel lncRNA, LOC728290, in HCC. Expression of LOC728290 was markedly decreased in HCC tissues compared with adjacent non‑tumor liver tissues, as detected using the reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). The area under the receiver operating characteristic curve for LOC728290 was 0.728. The expression of LOC728290 was associated with the level of α‑fetoprotein and microvascular invasion. Furthermore, patients with low LOC728290 expression exhibited decreased recurrence‑free survival times (P<0.05) compared with those with high LOC728290 expression. The results of the present study indicated that downregulation of LOC728290 in patients with HCC may be a powerful tumor biomarker, with potential clinical applications in prognosis as well as a therapeutic target.
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1 

Tsochatzis EA, Meyer T and Burroughs AK: Hepatocellular carcinoma. N Engl J Med. 366:92–93. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Llovet JM, Burroughs A and Bruix J: Hepatocellular carcinoma. Lancet. 362:1907–1917. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Maluccio M and Covey A: Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma. CA Cancer J Clin. 62:394–399. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Zimmerman MA, Ghobrial RM, Tong MJ, Hiatt JR, Cameron AM, Hong J and Busuttil RW: Recurrence of hepatocellular carcinoma following liver transplantation: A review of preoperative and postoperative prognostic indicators. Arch Surg. 143:182–188. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Ludwig JA and Weinstein JN: Biomarkers in cancer staging, prognosis and treatment selection. Nat Rev Cancer. 5:845–856. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Esteller M: Non-coding RNAs in human disease. Nat Rev Genet. 12:861–874. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Kung JT, Colognori D and Lee JT: Long noncoding RNAs: Past, present, and future. Genetics. 193:651–669. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Wang J, Xie G, Singh M, Ghanbarian AT, Raskó T, Szvetnik A, Cai H, Besser D, Prigione A, Fuchs NV, et al: Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells. Nature. 516:405–409. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Wang Y, Wang Y, Li J, Zhang Y, Yin H and Han B: CRNDE, a long-noncoding RNA, promotes glioma cell growth and invasion through mTOR signaling. Cancer Lett. 367:122–128. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Leveille N, Melo CA, Rooijers K, Díaz-Lagares A, Melo SA, Korkmaz G, Lopes R, Moqadam Akbari F, Maia AR, Wijchers PJ, et al: Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA. Nat Commun. 6:65202015. View Article : Google Scholar : PubMed/NCBI

11 

Qiu JJ, Wang Y, Ding JX, Jin HY, Yang G and Hua KQ: The long non-coding RNA HOTAIR promotes the proliferation of serous ovarian cancer cells through the regulation of cell cycle arrest and apoptosis. Exp Cell Res. 333:238–248. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Cui M, Xiao Z, Wang Y, Zheng M, Song T, Cai X, Sun B, Ye L and Zhang X: Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway. Cancer Res. 75:846–857. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Tang J, Jiang R, Deng L, Zhang X, Wang K and Sun B: Circulation long non-coding RNAs act as biomarkers for predicting tumorigenesis and metastasis in hepatocellular carcinoma. Oncotarget. 6:4505–4515. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Xu D, Yang F, Yuan JH, Zhang L, Bi HS, Zhou CC, Liu F, Wang F and Sun SH: Long noncoding RNAs associated with liver regeneration 1 accelerates hepatocyte proliferation during liver regeneration by activating Wnt/β-catenin signaling. Hepatology. 58:739–751. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Yuan JH, Yang F, Wang F, Ma JZ, Guo YJ, Tao QF, Liu F, Pan W, Wang TT, Zhou CC, et al: A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma. Cancer Cell. 25:666–681. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Wang F, Yuan JH, Wang SB, Yang F, Yuan SX, Ye C, Yang N, Zhou WP, Li WL, Li W and Sun SH: Oncofetal long noncoding RNA PVT1 promotes proliferation and stem cell-like property of hepatocellular carcinoma cells by stabilizing NOP2. Hepatology. 60:1278–1290. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Lechel A and Gougelet A: Early HCC treatment: A future strategy against interferon/miR-484 axis to revert precancerous lesions? Gut. 65:1073–1074. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Iguchi T, Uchi R, Nambara S, Saito T, Komatsu H, Hirata H, Ueda M, Sakimura S, Takano Y, Kurashige J, et al: A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer. Anticancer Res. 35:1385–1388. 2015.PubMed/NCBI

20 

Qiu JJ, Lin YY, Ding JX, Feng WW, Jin HY and Hua KQ: Long non-coding RNA ANRIL predicts poor prognosis and promotes invasion/metastasis in serous ovarian cancer. Int J Oncol. 46:2497–2505. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Yue B, Qiu S, Zhao S, Liu C, Zhang D, Yu F, Peng Z and Yan D: LncRNA-ATB mediated E-cadherin repression promotes the progression of colon cancer and predicts poor prognosis. J Gastroenterol Hepatol. 31:595–603. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Luo F, Sun B, Li H, Xu Y, Liu Y, Liu X, Lu L, Li J, Wang Q, Wei S, et al: A MALAT1/HIF-2α feedback loop contributes to arsenite carcinogenesis. Oncotarget. 7:5769–5787. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Panzitt K, Tschernatsch MM, Guelly C, Moustafa T, Stradner M, Strohmaier HM, Buck CR, Denk H, Schroeder R, Trauner M and Zatloukal K: Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA. Gastroenterology. 132:330–342. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Ohrnberger S, Thavamani A, Braeuning A, Lipka DB, Kirilov M, Geffers R, Autenrieth SE, Römer M, Zell A, Bonin M, et al: Dysregulated serum response factor triggers formation of hepatocellular carcinoma. Hepatology. 61:979–989. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Li J, Chen Z, Tian L, Zhou C, He MY, Gao Y, Wang S, Zhou F, Shi S, Feng X, et al: LncRNA profile study reveals a three-lncRNA signature associated with the survival of patients with oesophageal squamous cell carcinoma. Gut. 63:1700–1710. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Thum T: Noncoding RNAs and myocardial fibrosis. Nat Rev Cardiol. 11:655–663. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Zhang S, Chen S, Yang G, Gu F, Li M, Zhong B, Hu J, Hoffman A and Chen M: Long noncoding RNA HOTAIR as an independent prognostic marker in cancer: A meta-analysis. PLoS One. 9:e1055382014. View Article : Google Scholar : PubMed/NCBI

28 

Carr BI, Guerra V, Giannini EG, Farinati F, Ciccarese F, Rapaccini GL, Di Marco M, Benvegnù L, Zoli M, Borzio F, et al: Significance of platelet and AFP levels and liver function parameters for HCC size and survival. Int J Biol Markers. 29:e215–e223. 2014.PubMed/NCBI

29 

Dwyer JP, Hosking P and Lubel J: Multiple liver lesions in a patient with positive hepatitis C serology and elevated AFP: Is it HCC? Gastroenterology. 147:e12–e13. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Li T, Xie J, Shen C, Cheng D, Shi Y, Wu Z, Deng X, Chen H, Shen B, Peng C, et al: Upregulation of long noncoding RNA ZEB1-AS1 promotes tumor metastasis and predicts poor prognosis in hepatocellular carcinoma. Oncogene. 35:1575–1584. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Li T, Xie J, Shen C, Cheng D, Shi Y, Wu Z, Deng X, Chen H, Shen B, Peng C, et al: Amplification of long noncoding RNA ZFAS1 promotes metastasis in hepatocellular carcinoma. Cancer Res. 75:3181–3191. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang SG, Li YF, Zhao NN, Lai CC, Cheng SJ, Yan J, Zhang P, Wang Z, Wang XL, Yang PH, Yang PH, et al: Decreased expression of long non‑coding RNA LOC728290 in human hepatocellular carcinoma. Oncol Lett 14: 4551-4556, 2017.
APA
Zhang, S., Li, Y., Zhao, N., Lai, C., Cheng, S., Yan, J. ... Yang, P. (2017). Decreased expression of long non‑coding RNA LOC728290 in human hepatocellular carcinoma. Oncology Letters, 14, 4551-4556. https://doi.org/10.3892/ol.2017.6776
MLA
Zhang, S., Li, Y., Zhao, N., Lai, C., Cheng, S., Yan, J., Zhang, P., Wang, Z., Wang, X., Yang, P."Decreased expression of long non‑coding RNA LOC728290 in human hepatocellular carcinoma". Oncology Letters 14.4 (2017): 4551-4556.
Chicago
Zhang, S., Li, Y., Zhao, N., Lai, C., Cheng, S., Yan, J., Zhang, P., Wang, Z., Wang, X., Yang, P."Decreased expression of long non‑coding RNA LOC728290 in human hepatocellular carcinoma". Oncology Letters 14, no. 4 (2017): 4551-4556. https://doi.org/10.3892/ol.2017.6776
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang SG, Li YF, Zhao NN, Lai CC, Cheng SJ, Yan J, Zhang P, Wang Z, Wang XL, Yang PH, Yang PH, et al: Decreased expression of long non‑coding RNA LOC728290 in human hepatocellular carcinoma. Oncol Lett 14: 4551-4556, 2017.
APA
Zhang, S., Li, Y., Zhao, N., Lai, C., Cheng, S., Yan, J. ... Yang, P. (2017). Decreased expression of long non‑coding RNA LOC728290 in human hepatocellular carcinoma. Oncology Letters, 14, 4551-4556. https://doi.org/10.3892/ol.2017.6776
MLA
Zhang, S., Li, Y., Zhao, N., Lai, C., Cheng, S., Yan, J., Zhang, P., Wang, Z., Wang, X., Yang, P."Decreased expression of long non‑coding RNA LOC728290 in human hepatocellular carcinoma". Oncology Letters 14.4 (2017): 4551-4556.
Chicago
Zhang, S., Li, Y., Zhao, N., Lai, C., Cheng, S., Yan, J., Zhang, P., Wang, Z., Wang, X., Yang, P."Decreased expression of long non‑coding RNA LOC728290 in human hepatocellular carcinoma". Oncology Letters 14, no. 4 (2017): 4551-4556. https://doi.org/10.3892/ol.2017.6776
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