|
1
|
Berry DA, Cronin KA, Plevritis SK, Fryback
DG, Clarke L, Zelen M, Mandelblatt JS, Yakovlev AY, Habbema JD and
Feuer EJ: Cancer Intervention and Surveillance Modeling Network
(CISNET) Collaborators: Effect of screening and adjuvant therapy on
mortality from breast cancer. N Engl J Med. 353:1784–1792. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Ferlay J, Steliarova-Foucher E,
Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, Forman D and
Bray F: Cancer incidence and mortality patterns in Europe:
Estimates for 40 countries in 2012. Eur J Cancer. 49:1374–1403.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Pagani O, Senkus E, Wood W, Colleoni M,
Cufer T, Kyriakides S, Costa A, Winer EP and Cardoso F: ESO-MBC
Task Force: International guidelines for management of metastatic
breast cancer: Can metastatic breast cancer be cured? J Natl Cancer
Inst. 102:456–463. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
O'Driscoll L and Clynes M: Biomarkers and
multiple drug resistance in breast cancer. Curr Cancer Drug
Targets. 6:365–384. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Coley HM: Mechanisms and strategies to
overcome chemotherapy resistance in metastatic breast cancer.
Cancer Treat Rev. 34:378–390. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Istvan ES and Deisenhofer J: Structural
mechanism for statin inhibition of HMG-CoA reductase. Science.
292:1160–1164. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Hoeg JM and Brewer HB Jr:
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in the
treatment of hypercholesterolemia. JAMA. 258:3532–3536. 1987.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Watanabe Y, Ito T, Shiomi M, Tsujita Y,
Kuroda M, Arai M, Fukami M and Tamura A: Preventive effect of
pravastatin sodium, a potent inhibitor of
3-hydroxy-3-methylglutaryl coenzyme A reductase, on coronary
atherosclerosis and xanthoma in WHHL rabbits. Biochim Biophys Acta.
960:294–302. 1988. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Downs JR, Clearfield M, Weis S, Whitney E,
Shapiro DR, Beere PA, Langendorfer A, Stein EA, Kruyer W and Gotto
AM Jr: Primary prevention of acute coronary events with lovastatin
in men and women with average cholesterol levels: Results of
AFCAPS/TexCAPS. Air Force/Texas coronary atherosclerosis prevention
study. JAMA. 279:1615–1622. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Khush KK and Waters DD: Effects of statin
therapy on the development and progression of heart failure:
Mechanisms and clinical trials. J Card Fail. 12:664–674. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Qi XF, Kim DH, Yoon YS, Li JH, Jin D, Teng
YC, Kim SK and Lee KJ: Fluvastatin inhibits expression of the
chemokine MDC/CCL22 induced by interferon-gamma in HaCaT cells, a
human keratinocyte cell line. Br J Pharmacol. 157:1441–1450. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Blum A and Shamburek R: The pleiotropic
effects of statins on endothelial function, vascular inflammation,
immunomodulation and thrombogenesis. Atherosclerosis. 203:325–330.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Elewa HF, El-Remessy AB, Somanath PR and
Fagan SC: Diverse effects of statins on angiogenesis: New
therapeutic avenues. Pharmacotherapy. 30:169–176. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Cai JP, Chen W, Hou X, Liang LJ, Hao XY
and Yin XY: Simvastatin enhances the chemotherapeutic efficacy of
S-1 against bile duct cancer: E2F-1/TS downregulation might be the
mechanism. Anticancer Drugs. 24:1020–1029. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Kamigaki M, Sasaki T, Serikawa M, Inoue M,
Kobayashi K, Itsuki H, Minami T, Yukutake M, Okazaki A, Ishigaki T,
et al: Statins induce apoptosis and inhibit proliferation in
cholangiocarcinoma cells. Int J Oncol. 39:561–568. 2011.PubMed/NCBI
|
|
16
|
Shen Y, Du Y, Zhang Y and Pan Y:
Synergistic effects of combined treatment with simvastatin and
exemestane on MCF-7 human breast cancer cells. Mol Med Rep.
12:456–462. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Spampanato C, De Maria S, Sarnataro M,
Giordano E, Zanfardino M, Baiano S, Cartenì M and Morelli F:
Simvastatin inhibits cancer cell growth by inducing apoptosis
correlated to activation of Bax and down-regulation of BCL-2 gene
expression. Int J Oncol. 40:935–941. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Miller T, Yang F, Wise CE, Meng F,
Priester S, Munshi MK, Guerrier M, Dostal DE and Glaser SS:
Simvastatin stimulates apoptosis in cholangiocarcinoma by
inhibition of Rac1 activity. Dig Liver Dis. 43:395–403. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Werner M, Sacher J and Hohenegger M:
Mutual amplification of apoptosis by statin-induced mitochondrial
stress and doxorubicin toxicity in human rhabdomyosarcoma cells. Br
J Pharmacol. 143:715–724. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Sassano A and Platanias LC: Statins in
tumor suppression. Cancer Lett. 260:11–19. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Kusama T, Mukai M, Iwasaki T, Tatsuta M,
Matsumoto Y, Akedo H, Inoue M and Nakamura H:
3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce
human pancreatic cancer cell invasion and metastasis.
Gastroenterology. 122:308–317. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Wong WW, Dimitroulakos J, Minden MD and
Penn LZ: HMG-CoA reductase inhibitors and the malignant cell: The
statin family of drugs as triggers of tumor-specific apoptosis.
Leukemia. 16:508–519. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Jaffe AB and Hall A: Rho GTPases:
Biochemistry and biology. Annu Rev Cell Dev Biol. 21:247–269. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Bosco EE, Mulloy JC and Zheng Y: Rac1
GTPase: A “Rac” of all trades. Cell Mol Life Sci. 66:370–374. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Yoshida T, Zhang Y, Rosado Rivera LA, Chen
J, Khan T, Moon SY and Zhang B: Blockade of Rac1 activity induces
G1 cell cycle arrest or apoptosis in breast cancer cells through
downregulation of cyclin D1, survivin, and X-linked inhibitor of
apoptosis protein. Mol Cancer Ther. 9:1657–1668. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Goldstein JL and Brown MS: Regulation of
the mevalonate pathway. Nature. 343:425–430. 1990. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Martirosyan A, Clendening JW, Goard CA and
Penn LZ: Lovastatin induces apoptosis of ovarian cancer cells and
synergizes with doxorubicin: Potential therapeutic relevance. BMC
Cancer. 10:1032010. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Hindler K, Cleeland CS, Rivera E and
Collard CD: The role of statins in cancer therapy. Oncologist.
11:306–315. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Schnelzer A, Prechtel D, Knaus U, Dehne K,
Gerhard M, Graeff H, Harbeck N, Schmitt M and Lengyel E: Rac1 in
human breast cancer: Overexpression, mutation analysis, and
characterization of a new isoform, Rac1b. Oncogene. 19:3013–3020.
2000. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Eblen ST, Slack JK, Weber MJ and Catling
AD: Rac-PAK signaling stimulates extracellular signal-regulated
kinase (ERK) activation by regulating formation of MEK1-ERK
complexes. Mol Cell Biol. 22:6023–6033. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Saito A, Saito N, Mol W, Furukawa H,
Tsutsumida A, Oyama A, Sekido M, Sasaki S and Yamamoto Y:
Simvastatin inhibits growth via apoptosis and the induction of cell
cycle arrest in human melanoma cells. Melanoma Res. 18:85–94. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Sherr CJ and Roberts JM: CDK inhibitors:
Positive and negative regulators of G1-phase progression. Genes
Dev. 13:1501–1512. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Fournier AK, Campbell LE, Castagnino P,
Liu WF, Chung BM, Weaver VM, Chen CS and Assoian RK: Rac-dependent
cyclin D1 gene expression regulated by cadherin- and
integrin-mediated adhesion. J Cell Sci. 121:226–233. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Gartel AL and Tyner AL: The role of the
cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer
Ther. 1:639–649. 2002.PubMed/NCBI
|
|
36
|
D'Autréaux B and Toledano MB: ROS as
signalling molecules: Mechanisms that generate specificity in ROS
homeostasis. Nat Rev Mol Cell Biol. 8:813–824. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Sadeghi-Aliabadi H, Minaiyan M and
Dabestan A: Cytotoxic evaluation of doxorubicin in combination with
simvastatin against human cancer cells. Res Pharm Sci. 5:127–133.
2010.PubMed/NCBI
|
