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Case Report Open Access

Genetic basis of a common tumor origin in the development of pancreatic mixed acinar‑neuroendocrine‑ductal carcinoma: A case report

  • Authors:
    • Atsushi Takano
    • Yosuke Hirotsu
    • Kenji Amemiya
    • Hiroshi Nakagomi
    • Naoki Oishi
    • Toshio Oyama
    • Hitoshi Mochizuki
    • Masao Omata
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Yamanashi Central Hospital, Yamanashi 400‑8506, Japan, Genome Analysis Center, Yamanashi Central Hospital, Yamanashi 400‑8506, Japan, Department of Pathology, University of Yamanashi, Yamanashi 409‑3898; 5The University of Tokyo, Tokyo 113‑8655, Japan, Department of Pathology, Yamanashi Central Hospital, Yamanashi 400‑8506, Japan
    Copyright: © Takano et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4428-4432
    |
    Published online on: August 22, 2017
       https://doi.org/10.3892/ol.2017.6786
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Abstract

Pancreatic cancer is classified as ductal, acinar, neuroendocrine carcinoma or pancreatoblastoma. Ductal and acinar cells derive from exocrine glands and neuroendocrine cells from endocrine glands; however, mixed acinar‑neuroendocrine‑ductal carcinoma has different histological carcinomas coexisting within a nodule. The mixed pancreatic carcinoma forms from different developmental origins and therefore requires investigation. The current case report presents a 50‑year‑old male who had a tumor within the body of the pancreas. Pathological examination clarified the tumor as a mixed acinar-neuroendocrine‑ductal carcinoma. The ductal and acinar/neuroendocrine tumor components were isolated using laser‑capture microdissection, and next‑generation sequencing analysis was performed. Consequently, TP53 frameshift (p.N210fs) and KRAS missense (p.G12R) mutations were identified in both ductal and acinar/neuroendocrine tumors. These results suggested a pancreatic mixed acinar‑neuroendocrine‑ductal carcinoma was derived from a founder tumor clone, and supports the notion that a founder tumor clone may differentiate and transform into a diverse histological type and form a pancreatic mixed carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Takano A, Hirotsu Y, Amemiya K, Nakagomi H, Oishi N, Oyama T, Mochizuki H and Omata M: Genetic basis of a common tumor origin in the development of pancreatic mixed acinar‑neuroendocrine‑ductal carcinoma: A case report. Oncol Lett 14: 4428-4432, 2017.
APA
Takano, A., Hirotsu, Y., Amemiya, K., Nakagomi, H., Oishi, N., Oyama, T. ... Omata, M. (2017). Genetic basis of a common tumor origin in the development of pancreatic mixed acinar‑neuroendocrine‑ductal carcinoma: A case report. Oncology Letters, 14, 4428-4432. https://doi.org/10.3892/ol.2017.6786
MLA
Takano, A., Hirotsu, Y., Amemiya, K., Nakagomi, H., Oishi, N., Oyama, T., Mochizuki, H., Omata, M."Genetic basis of a common tumor origin in the development of pancreatic mixed acinar‑neuroendocrine‑ductal carcinoma: A case report". Oncology Letters 14.4 (2017): 4428-4432.
Chicago
Takano, A., Hirotsu, Y., Amemiya, K., Nakagomi, H., Oishi, N., Oyama, T., Mochizuki, H., Omata, M."Genetic basis of a common tumor origin in the development of pancreatic mixed acinar‑neuroendocrine‑ductal carcinoma: A case report". Oncology Letters 14, no. 4 (2017): 4428-4432. https://doi.org/10.3892/ol.2017.6786
Copy and paste a formatted citation
x
Spandidos Publications style
Takano A, Hirotsu Y, Amemiya K, Nakagomi H, Oishi N, Oyama T, Mochizuki H and Omata M: Genetic basis of a common tumor origin in the development of pancreatic mixed acinar‑neuroendocrine‑ductal carcinoma: A case report. Oncol Lett 14: 4428-4432, 2017.
APA
Takano, A., Hirotsu, Y., Amemiya, K., Nakagomi, H., Oishi, N., Oyama, T. ... Omata, M. (2017). Genetic basis of a common tumor origin in the development of pancreatic mixed acinar‑neuroendocrine‑ductal carcinoma: A case report. Oncology Letters, 14, 4428-4432. https://doi.org/10.3892/ol.2017.6786
MLA
Takano, A., Hirotsu, Y., Amemiya, K., Nakagomi, H., Oishi, N., Oyama, T., Mochizuki, H., Omata, M."Genetic basis of a common tumor origin in the development of pancreatic mixed acinar‑neuroendocrine‑ductal carcinoma: A case report". Oncology Letters 14.4 (2017): 4428-4432.
Chicago
Takano, A., Hirotsu, Y., Amemiya, K., Nakagomi, H., Oishi, N., Oyama, T., Mochizuki, H., Omata, M."Genetic basis of a common tumor origin in the development of pancreatic mixed acinar‑neuroendocrine‑ductal carcinoma: A case report". Oncology Letters 14, no. 4 (2017): 4428-4432. https://doi.org/10.3892/ol.2017.6786
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