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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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October-2017 Volume 14 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Case Report

Long‑term follow‑up of complete remission of advanced hepatocellular carcinoma following sorafenib therapy: A case report

  • Authors:
    • Jung Gil Park
    • Won Young Tak
    • Soo Young Park
    • Young Oh Kweon
    • Se Young Jang
    • Soo Hyun Lee
    • Yu Rim Lee
    • Sun Kyung Jang
    • Keun Hur
    • Heon Ju Lee
  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 41940, Republic of Korea, Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 41940, Republic of Korea, Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu 41940, Republic of Korea
  • Pages: 4853-4856
    |
    Published online on: August 22, 2017
       https://doi.org/10.3892/ol.2017.6788
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Abstract

Sorafenib is a tyrosine kinase inhibitor that has been demonstrated to improve the overall survival time of patients with advanced hepatocellular carcinoma (HCC). Although there have been a number of reports of patients achieving complete remission (CR) following sorafenib therapy, the long‑term clinical outcomes of these patients have yet to be ascertained. A 72‑year‑old male patient with chronic hepatitis C, diabetes, hypertension and an old cerebral infarction was referred for the evaluation of a liver mass identified on an abdominal ultrasound. Abdominal computed tomography (CT) demonstrated a 13‑cm mass replacing the right lobe of the liver, with portal vein thrombosis. HCC was confirmed by a percutaneous needle biopsy and treated with sorafenib. At 4 months, a follow‑up CT demonstrated no enhancing viable lesions in the tumor and recanalization of the portal vein. Sorafenib therapy was continued for 48 months until the patient experienced dyspnea due to congestive heart failure, with pleural effusion. Following the discontinuation of sorafenib, the patient's symptoms improved. The patient followed up without recurrence for 52 months. Subsequent to achieving CR through treatment with sorafenib, long‑term sorafenib therapy may be an option and efforts should be made to monitor cardiac toxicity during sorafenib therapy, particularly in high‑risk patients.
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Copy and paste a formatted citation
Spandidos Publications style
Park JG, Tak WY, Park SY, Kweon YO, Jang SY, Lee SH, Lee YR, Jang SK, Hur K, Lee HJ, Lee HJ, et al: Long‑term follow‑up of complete remission of advanced hepatocellular carcinoma following sorafenib therapy: A case report. Oncol Lett 14: 4853-4856, 2017.
APA
Park, J.G., Tak, W.Y., Park, S.Y., Kweon, Y.O., Jang, S.Y., Lee, S.H. ... Lee, H.J. (2017). Long‑term follow‑up of complete remission of advanced hepatocellular carcinoma following sorafenib therapy: A case report. Oncology Letters, 14, 4853-4856. https://doi.org/10.3892/ol.2017.6788
MLA
Park, J. G., Tak, W. Y., Park, S. Y., Kweon, Y. O., Jang, S. Y., Lee, S. H., Lee, Y. R., Jang, S. K., Hur, K., Lee, H. J."Long‑term follow‑up of complete remission of advanced hepatocellular carcinoma following sorafenib therapy: A case report". Oncology Letters 14.4 (2017): 4853-4856.
Chicago
Park, J. G., Tak, W. Y., Park, S. Y., Kweon, Y. O., Jang, S. Y., Lee, S. H., Lee, Y. R., Jang, S. K., Hur, K., Lee, H. J."Long‑term follow‑up of complete remission of advanced hepatocellular carcinoma following sorafenib therapy: A case report". Oncology Letters 14, no. 4 (2017): 4853-4856. https://doi.org/10.3892/ol.2017.6788
Copy and paste a formatted citation
x
Spandidos Publications style
Park JG, Tak WY, Park SY, Kweon YO, Jang SY, Lee SH, Lee YR, Jang SK, Hur K, Lee HJ, Lee HJ, et al: Long‑term follow‑up of complete remission of advanced hepatocellular carcinoma following sorafenib therapy: A case report. Oncol Lett 14: 4853-4856, 2017.
APA
Park, J.G., Tak, W.Y., Park, S.Y., Kweon, Y.O., Jang, S.Y., Lee, S.H. ... Lee, H.J. (2017). Long‑term follow‑up of complete remission of advanced hepatocellular carcinoma following sorafenib therapy: A case report. Oncology Letters, 14, 4853-4856. https://doi.org/10.3892/ol.2017.6788
MLA
Park, J. G., Tak, W. Y., Park, S. Y., Kweon, Y. O., Jang, S. Y., Lee, S. H., Lee, Y. R., Jang, S. K., Hur, K., Lee, H. J."Long‑term follow‑up of complete remission of advanced hepatocellular carcinoma following sorafenib therapy: A case report". Oncology Letters 14.4 (2017): 4853-4856.
Chicago
Park, J. G., Tak, W. Y., Park, S. Y., Kweon, Y. O., Jang, S. Y., Lee, S. H., Lee, Y. R., Jang, S. K., Hur, K., Lee, H. J."Long‑term follow‑up of complete remission of advanced hepatocellular carcinoma following sorafenib therapy: A case report". Oncology Letters 14, no. 4 (2017): 4853-4856. https://doi.org/10.3892/ol.2017.6788
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