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Article

Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling

  • Authors:
    • Yu Gan
    • Qing Chen
    • Yan Lei
  • View Affiliations / Copyright

    Affiliations: Qingshan Clinic, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, P.R. China, Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Pharmacy of University Hospital, Huazhong University of Science and Technology, Wuhan, Hubei 430074, P.R. China
  • Pages: 4977-4982
    |
    Published online on: August 23, 2017
       https://doi.org/10.3892/ol.2017.6793
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Abstract

Taxol is the first‑line chemotherapeutic agent for patients with castration‑resistant prostate cancer. However, the mechanism of the sensitivity of prostate cancer cells to Taxol treatment remains to be elucidated. In the present study, it was found that paclitaxel induced more apoptosis and maspin expression in phosphatase and tensin homolog (PTEN)‑positive 22Rv1 cells than PTEN‑negative LNCaP cells. Knockdown of PTEN in 22Rv1 cells resulted in increased resistance to paclitaxel and impaired the induction of maspin expression by paclitaxel. Overexpression of PTEN sensitized LNCaP cells to paclitaxel treatment and increased maspin induction by paclitaxel. Furthermore, knocking down maspin abrogated PTEN‑induced paclitaxel sensitivity in LNCaP cells. PTEN/maspin signaling may be important for regulating the susceptibility to paclitaxel in prostate cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Gan Y, Chen Q and Lei Y: Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling. Oncol Lett 14: 4977-4982, 2017.
APA
Gan, Y., Chen, Q., & Lei, Y. (2017). Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling. Oncology Letters, 14, 4977-4982. https://doi.org/10.3892/ol.2017.6793
MLA
Gan, Y., Chen, Q., Lei, Y."Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling". Oncology Letters 14.4 (2017): 4977-4982.
Chicago
Gan, Y., Chen, Q., Lei, Y."Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling". Oncology Letters 14, no. 4 (2017): 4977-4982. https://doi.org/10.3892/ol.2017.6793
Copy and paste a formatted citation
x
Spandidos Publications style
Gan Y, Chen Q and Lei Y: Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling. Oncol Lett 14: 4977-4982, 2017.
APA
Gan, Y., Chen, Q., & Lei, Y. (2017). Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling. Oncology Letters, 14, 4977-4982. https://doi.org/10.3892/ol.2017.6793
MLA
Gan, Y., Chen, Q., Lei, Y."Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling". Oncology Letters 14.4 (2017): 4977-4982.
Chicago
Gan, Y., Chen, Q., Lei, Y."Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling". Oncology Letters 14, no. 4 (2017): 4977-4982. https://doi.org/10.3892/ol.2017.6793
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