Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling

  • Authors:
    • Yu Gan
    • Qing Chen
    • Yan Lei
  • View Affiliations

  • Published online on: August 23, 2017     https://doi.org/10.3892/ol.2017.6793
  • Pages: 4977-4982
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Taxol is the first‑line chemotherapeutic agent for patients with castration‑resistant prostate cancer. However, the mechanism of the sensitivity of prostate cancer cells to Taxol treatment remains to be elucidated. In the present study, it was found that paclitaxel induced more apoptosis and maspin expression in phosphatase and tensin homolog (PTEN)‑positive 22Rv1 cells than PTEN‑negative LNCaP cells. Knockdown of PTEN in 22Rv1 cells resulted in increased resistance to paclitaxel and impaired the induction of maspin expression by paclitaxel. Overexpression of PTEN sensitized LNCaP cells to paclitaxel treatment and increased maspin induction by paclitaxel. Furthermore, knocking down maspin abrogated PTEN‑induced paclitaxel sensitivity in LNCaP cells. PTEN/maspin signaling may be important for regulating the susceptibility to paclitaxel in prostate cancer.
View Figures
View References

Related Articles

Journal Cover

October-2017
Volume 14 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Gan Y, Chen Q and Lei Y: Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling. Oncol Lett 14: 4977-4982, 2017
APA
Gan, Y., Chen, Q., & Lei, Y. (2017). Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling. Oncology Letters, 14, 4977-4982. https://doi.org/10.3892/ol.2017.6793
MLA
Gan, Y., Chen, Q., Lei, Y."Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling". Oncology Letters 14.4 (2017): 4977-4982.
Chicago
Gan, Y., Chen, Q., Lei, Y."Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling". Oncology Letters 14, no. 4 (2017): 4977-4982. https://doi.org/10.3892/ol.2017.6793