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Article Open Access

CD147 expression correlates with lymph node metastasis in T1‑T2 squamous cell carcinoma of the tongue

  • Authors:
    • Shinsuke Suzuki
    • Kohei Honda
    • Hiroshi Nanjo
    • Nobuko Iikawa
    • Tadahiro Tsuji
    • Yohei Kawasaki
    • Kazuharu Yamazaki
    • Teruyuki Sato
    • Hidekazu Saito
    • Kazuhiro Shiina
    • Kazuo Ishikawa
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology and Head and Neck Surgery, Akita University Graduate School of Medicine, Akita 010‑8543, Japan, Division of Surgical Pathology, Akita University Hospital, Akita 010‑8543, Japan
    Copyright: © Suzuki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4670-4676
    |
    Published online on: August 24, 2017
       https://doi.org/10.3892/ol.2017.6808
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Abstract

Cervical lymph node metastasis causes a poor prognosis in cases of stage T1‑T2 squamous cell carcinoma (SCC) of the tongue. Recent studies have reported that cluster of differentiation (CD)147, also known as extracellular matrix metalloproteinase inducer, contributes to tumor progression. The present study evaluated the role of CD147 in the tumorigenesis of SCC of the tongue in vitro, as well as the association between CD147 expression and cervical lymph node metastasis in clinical samples of SCC of the tongue. Tongue SCC cell lines were used to evaluate in vitro tumorigenesis. In addition, 41 patients with clinical stage T1‑T2 tongue SCC were assessed with a histopathological analysis. Univariate and multivariate analysis were performed to investigate the risk of cervical lymph node metastasis associated with histopathological findings. In the in vitro study, cell invasiveness was upregulated by S100 calcium‑binding protein A9 (S100A9) stimulation and downregulated following CD147‑blocking antibody treatment. The univariate and multivariate analyses identified CD147 expression in the invasive tumor front as an independent risk factor for metastasis. It was concluded that CD147 induces tongue carcinoma cell invasion through its interaction with S100A9. Thus, an evaluation of the extent of CD147 expression in cancer cell nests at the invasive tumor front may help in predicting cervical lymph node metastasis in patients with clinical N0 T1‑T2 tongue SCC.
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Copy and paste a formatted citation
Spandidos Publications style
Suzuki S, Honda K, Nanjo H, Iikawa N, Tsuji T, Kawasaki Y, Yamazaki K, Sato T, Saito H, Shiina K, Shiina K, et al: CD147 expression correlates with lymph node metastasis in T1‑T2 squamous cell carcinoma of the tongue. Oncol Lett 14: 4670-4676, 2017.
APA
Suzuki, S., Honda, K., Nanjo, H., Iikawa, N., Tsuji, T., Kawasaki, Y. ... Ishikawa, K. (2017). CD147 expression correlates with lymph node metastasis in T1‑T2 squamous cell carcinoma of the tongue. Oncology Letters, 14, 4670-4676. https://doi.org/10.3892/ol.2017.6808
MLA
Suzuki, S., Honda, K., Nanjo, H., Iikawa, N., Tsuji, T., Kawasaki, Y., Yamazaki, K., Sato, T., Saito, H., Shiina, K., Ishikawa, K."CD147 expression correlates with lymph node metastasis in T1‑T2 squamous cell carcinoma of the tongue". Oncology Letters 14.4 (2017): 4670-4676.
Chicago
Suzuki, S., Honda, K., Nanjo, H., Iikawa, N., Tsuji, T., Kawasaki, Y., Yamazaki, K., Sato, T., Saito, H., Shiina, K., Ishikawa, K."CD147 expression correlates with lymph node metastasis in T1‑T2 squamous cell carcinoma of the tongue". Oncology Letters 14, no. 4 (2017): 4670-4676. https://doi.org/10.3892/ol.2017.6808
Copy and paste a formatted citation
x
Spandidos Publications style
Suzuki S, Honda K, Nanjo H, Iikawa N, Tsuji T, Kawasaki Y, Yamazaki K, Sato T, Saito H, Shiina K, Shiina K, et al: CD147 expression correlates with lymph node metastasis in T1‑T2 squamous cell carcinoma of the tongue. Oncol Lett 14: 4670-4676, 2017.
APA
Suzuki, S., Honda, K., Nanjo, H., Iikawa, N., Tsuji, T., Kawasaki, Y. ... Ishikawa, K. (2017). CD147 expression correlates with lymph node metastasis in T1‑T2 squamous cell carcinoma of the tongue. Oncology Letters, 14, 4670-4676. https://doi.org/10.3892/ol.2017.6808
MLA
Suzuki, S., Honda, K., Nanjo, H., Iikawa, N., Tsuji, T., Kawasaki, Y., Yamazaki, K., Sato, T., Saito, H., Shiina, K., Ishikawa, K."CD147 expression correlates with lymph node metastasis in T1‑T2 squamous cell carcinoma of the tongue". Oncology Letters 14.4 (2017): 4670-4676.
Chicago
Suzuki, S., Honda, K., Nanjo, H., Iikawa, N., Tsuji, T., Kawasaki, Y., Yamazaki, K., Sato, T., Saito, H., Shiina, K., Ishikawa, K."CD147 expression correlates with lymph node metastasis in T1‑T2 squamous cell carcinoma of the tongue". Oncology Letters 14, no. 4 (2017): 4670-4676. https://doi.org/10.3892/ol.2017.6808
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