Prognostic value of 18F‑fluorodeoxyglucose PET parameters and inflammation in patients with nasopharyngeal carcinoma

Zhong,Liting; Li,Chunming; Ren,Yunyan; Wu,Dehua

doi:10.3892/ol.2017.6816

Prognostic value of 18F‑fluorodeoxyglucose PET parameters and inflammation in patients with nasopharyngeal carcinoma

Authors:
- Liting Zhong
- Chunming Li
- Yunyan Ren
- Dehua Wu
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Affiliations: Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Oncology, Jiangmen Central Hospital, Jiangmen, Guangdong 529000, P.R. China, Department of Nuclear Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
Published online on: August 24, 2017 https://doi.org/10.3892/ol.2017.6816
Pages: 5004-5012

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Abstract

The aim of the present study was to investigate the association between positron emission tomography (PET) parameters and peripheral inflammatory markers, and assess their prognostic value in nasopharyngeal carcinoma (NPC). A total of 121 patients with non‑disseminated NPC were recruited. Pretreatment maximum standardized uptake values (SUVmax) of PET and peripheral inflammatory factors (leukocyte, neutrophil and monocyte counts) were recorded. Kaplan‑Meier and multivariate analyses were used to identify predictors for progression‑free survival (PFS), overall survival (OS), distant metastasis‑free survival (DMFS) and locoregional recurrence‑free survival (LRFS). The results of the present study revealed that SUVmax at the primary tumor was positively correlated with leukocytes (P=0.025), neutrophils (P=0.009) and monocytes (P=0.043). SUVmax at regional lymph nodes (SUVmax‑N) was significantly associated with monocytes (P=0.024). Kaplan‑Meier analysis demonstrated that SUVmax‑N (>10.15) significantly predicted PFS (P=0.004) and DMFS (P=0.003). In addition, neutrophils (>5.18) were significantly associated with PFS (P=0.001), DMFS (P=0.013) and LRFS (P<0.001). Multivariate analysis revealed that SUVmax‑N and neutrophils retained independent prognostic significance for PFS (SUVmax‑N, P=0.026; and neutrophils, P=0.033) and DMFS (SUVmax‑N, P=0.026; and neutrophils, P=0.032). Furthermore, patients with SUVmax‑N ≤10.15 and neutrophils ≤5.18 had significantly improved prognosis in PFS (96.4 vs. 58.5%, P<0.001), OS (95.7 vs. 81.1%, P=0.044), DMFS (96.4 vs. 67.0%, P<0.001) and LRFS (100 vs. 90.2%, P=0.036) compared with those with SUVmax‑N >10.15 or neutrophils >5.18. In conclusion, SUVmax may be significantly associated with cancer‑associated inflammation. SUVmax‑N and neutrophils were independent prognostic indicators for PFS and DMFS. Combined assessment of SUVmax‑N and neutrophils may lead to refinement of risk stratification in NPC.

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