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Article

HDAC10 expression is associated with DNA mismatch repair gene and is a predictor of good prognosis in colon carcinoma

  • Authors:
    • Xiangxiang Tao
    • Yifeng Yan
    • Linming Lu
    • Bing Chen
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Wannan Medical College, Wuhu, Anhui 241001, P.R. China, Department of Forensic Pathology, Wannan Medical College, Wuhu, Anhui 241001, P.R. China
  • Pages: 4923-4929
    |
    Published online on: August 24, 2017
       https://doi.org/10.3892/ol.2017.6818
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Abstract

Despite increasing evidence of the involvement of histone deacetylase (HDAC)10 in cancer tumorigenesis, the potential role of HDAC10 in colon cancer remains unclear. Oncomine database analysis revealed that HDAC10 mRNA was significantly upregulated in colon cancer. In an independent cohort, consistent with mRNA expression levels, constitutively high HDAC10 expression was observed in the cytoplasm and nucleus compared with in adjacent normal tissues (cytoplasm, 93.12±12.98 vs. 31.65±26.50%; nucleus, 84.16±19.23 vs. 68.64±19.00%). Cytoplasmic HDAC expression correlated with gender (r=0.265; P<0.05), lymph node metastasis (N stage; r=0.256; P<0.05) and distant metastasis (M stage; r=0.331; P<0.05) in paracarcinoma tissues. Cytoplasmic HDAC10 expression in tumors was not associated with the four DNA mismatch repair genes examined, but was negatively correlated with mutL homolog 1 (MLH1) (r=‑0.244; P<0.05), mutS homolog (MSH)2 (r=‑0.410; P<0.01) and MSH6 (r=‑0.240; P<0.05) in paracarcinoma tissues. Similarly, nuclear HDAC10 expression was negatively correlated with MLH1 expression (r=‑0.288; P<0.05). The findings of the current study suggest that HDAC10 expression is associated with good prognosis in colon cancer tissues and poor prognosis in paracarcinoma tissues with a potential involvement in DNA mismatch repair.
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Copy and paste a formatted citation
Spandidos Publications style
Tao X, Yan Y, Lu L and Chen B: HDAC10 expression is associated with DNA mismatch repair gene and is a predictor of good prognosis in colon carcinoma. Oncol Lett 14: 4923-4929, 2017.
APA
Tao, X., Yan, Y., Lu, L., & Chen, B. (2017). HDAC10 expression is associated with DNA mismatch repair gene and is a predictor of good prognosis in colon carcinoma. Oncology Letters, 14, 4923-4929. https://doi.org/10.3892/ol.2017.6818
MLA
Tao, X., Yan, Y., Lu, L., Chen, B."HDAC10 expression is associated with DNA mismatch repair gene and is a predictor of good prognosis in colon carcinoma". Oncology Letters 14.4 (2017): 4923-4929.
Chicago
Tao, X., Yan, Y., Lu, L., Chen, B."HDAC10 expression is associated with DNA mismatch repair gene and is a predictor of good prognosis in colon carcinoma". Oncology Letters 14, no. 4 (2017): 4923-4929. https://doi.org/10.3892/ol.2017.6818
Copy and paste a formatted citation
x
Spandidos Publications style
Tao X, Yan Y, Lu L and Chen B: HDAC10 expression is associated with DNA mismatch repair gene and is a predictor of good prognosis in colon carcinoma. Oncol Lett 14: 4923-4929, 2017.
APA
Tao, X., Yan, Y., Lu, L., & Chen, B. (2017). HDAC10 expression is associated with DNA mismatch repair gene and is a predictor of good prognosis in colon carcinoma. Oncology Letters, 14, 4923-4929. https://doi.org/10.3892/ol.2017.6818
MLA
Tao, X., Yan, Y., Lu, L., Chen, B."HDAC10 expression is associated with DNA mismatch repair gene and is a predictor of good prognosis in colon carcinoma". Oncology Letters 14.4 (2017): 4923-4929.
Chicago
Tao, X., Yan, Y., Lu, L., Chen, B."HDAC10 expression is associated with DNA mismatch repair gene and is a predictor of good prognosis in colon carcinoma". Oncology Letters 14, no. 4 (2017): 4923-4929. https://doi.org/10.3892/ol.2017.6818
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