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Review Open Access

Renin angiotensin system deregulation as renal cancer risk factor (Review)

  • Authors:
    • Paweł Sobczuk
    • Cezary Szczylik
    • Camillo Porta
    • Anna M. Czarnecka
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Military Institute of Medicine, 04‑141 Warsaw, Poland, Medical Oncology, I.R.C.C.S. San Matteo University Hospital Foundation, I‑27100 Pavia, Italy
    Copyright: © Sobczuk et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5059-5068
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    Published online on: August 25, 2017
       https://doi.org/10.3892/ol.2017.6826
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Abstract

For numerous years, the non‑cardiovascular role of the renin‑angiotensin system (RAS) was underestimated, but recent studies have advanced the understanding of its function in various processes, including carcinogenesis. Numerous evidence comes from preclinical and clinical studies on the use of antihypertensive agents targeting the RAS, including angiotensin‑converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers. It has been demonstrated that the use of ACEIs can alter the incidence of renal cell carcinoma (RCC) and may have a positive effect by prolonging patient survival. It has an effect on the complex action of ACEI, resulting in decreased angiotensin II (Ang‑II) production and altered levels of bradykinin or Ang 1‑7. The present review discusses the existing knowledge on the effects of ACE and its inhibitors on RCC cell lines, xenograft models, and patient survival in clinical studies. A brief introduction to molecular pathways aids in understanding the non‑cardiovascular effects of RAS inhibitors and enables the conduction of studies on combined cancer treatment with the application of ACEIs. Recent evidence regarding the treatment of hypertension associated with tyrosine kinase inhibitors, one of the most pronounced and common side effects in modern RCC treatment, are also outlined. Captopril, an ACEI, may be used to lower blood pressure in patients, particularly due to its additional renoprotective actions.
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1 

Motzer RJ, Bander NH and Nanus DM: Renal-cell carcinoma. N Engl J Med. 335:865–875. 1996. View Article : Google Scholar : PubMed/NCBI

2 

Lopez-Beltran A, Scarpelli M, Montironi R and Kirkali Z: 2004 WHO classification of the renal tumors of the adults. Eur Urol. 49:798–805. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Brodaczewska KK, Szczylik C, Fiedorowicz M, Porta C and Czarnecka AM: Choosing the right cell line for renal cell cancer research. Mol Cancer. 15:832016. View Article : Google Scholar : PubMed/NCBI

4 

Rydzanicz M, Wrzesinski T, Bluyssen HA and Wesoly J: Genomics and epigenomics of clear cell renal cell carcinoma: Recent developments and potential applications. Cancer Lett. 341:111–126. 2013. View Article : Google Scholar : PubMed/NCBI

5 

George AJ, Thomas WG and Hannan RD: The renin-angiotensin system and cancer: Old dog, new tricks. Nat Rev Cancer. 10:745–759. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Miyajima A, Kosaka T, Kikuchi E and Oya M: Renin-angiotensin system blockade: Its contribution and controversy. Int J Urol. 22:721–730. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Wegman-Ostrosky T, Soto-Reyes E, Vidal-Millán S and Sánchez-Corona J: The renin-angiotensin system meets the hallmarks of cancer. J Renin Angiotensin Aldosterone Syst. 16:227–233. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Derosa L, Izzedine H, Albiges L and Escudier B: Hypertension and angiotensin system inhibitors in patients with metastatic renal cell carcinoma. Oncol Rev. 10:2982016. View Article : Google Scholar : PubMed/NCBI

9 

Yin G, Yan C and Berk BC: Angiotensin II signaling pathways mediated by tyrosine kinases. Int J Biochem Cell Biol. 35:780–783. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, et al: A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1–9. Circ Res. 87:E1–E9. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G and Turner AJ: A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem. 275:33238–33243. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Zhuo JL and Li XC: New insights and perspectives on intrarenal renin-angiotensin system: Focus on intracrine/intracellular angiotensin II. Peptides. 32:1551–1565. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Norwood VF, Craig MR, Harris JM and Gomez RA: Differential expression of angiotensin II receptors during early renal morphogenesis. Am J Physiol. 272:R662–R668. 1997.PubMed/NCBI

14 

Arendshorst WJ, Brännström K and Ruan X: Actions of angiotensin II on the renal microvasculature. J Am Soc Nephrol. 10 Suppl 11:S149–S161. 1999.PubMed/NCBI

15 

Matsubara H, Sugaya T, Murasawa S, Nozawa Y, Mori Y, Masaki H, Maruyama K, Tsutumi Y, Shibasaki Y, Moriguchi Y, et al: Tissue-specific expression of human angiotensin II AT1 and AT2 receptors and cellular localization of subtype mRNAs in adult human renal cortex using in situ hybridization. Nephron. 80:25–34. 1998. View Article : Google Scholar : PubMed/NCBI

16 

Goldfarb DA, Diz DI, Tubbs RR, Ferrario CM and Novick AC: Angiotensin II receptor subtypes in the human renal cortex and renal cell carcinoma. J Urol. 151:208–213. 1994. View Article : Google Scholar : PubMed/NCBI

17 

Chatterjee PK, Weerackody RP, Mistry SK, Hawksworth GM and McLay JS: Selective antagonism of the AT1 receptor inhibits angiotensin II stimulated DNA and protein synthesis in primary cultures of human proximal tubular cells. Kidney Int. 52:699–705. 1997. View Article : Google Scholar : PubMed/NCBI

18 

Cao Z, Kelly DJ, Cox A, Casley D, Forbes JM, Martinello P, Dean R, Gilbert RE and Cooper ME: Angiotensin type 2 receptor is expressed in the adult rat kidney and promotes cellular proliferation and apoptosis. Kidney Int. 58:2437–2351. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Dolley-Hitze T, Jouan F, Martin B, Mottier S, Edeline J, Moranne O, Le Pogamp P, Belaud-Rotureau MA, Patard JJ, Rioux-Leclercq N and Vigneau C: Angiotensin-2 receptors (AT1-R and AT2-R), new prognostic factors for renal clear-cell carcinoma? Br J Cancer. 103:1698–1705. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Gonzalez-Villalobos RA, Shen XZ, Bernstein EA, Janjulia T, Taylor B, Giani JF, Blackwell WL, Shah KH, Shi PD, Fuchs S and Bernstein KE: Rediscovering ACE: Novel insights into the many roles of the angiotensin-converting enzyme. J Mol Med (Berl). 91:1143–1154. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Krege JH, John SW, Langenbach LL, Hodgin JB, Hagaman JR, Bachman ES, Jennette JC, O'Brien DA and Smithies O: Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature. 375:146–148. 1995. View Article : Google Scholar : PubMed/NCBI

22 

Lin C, Datta V, Okwan-Duodu D, Chen X, Fuchs S, Alsabeh R, Billet S, Bernstein KE and Shen XZ: Angiotensin-converting enzyme is required for normal myelopoiesis. FASEB J. 25:1145–1155. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Chappell MC: Emerging evidence for a functional angiotensin-converting enzyme 2-angiotensin-(1–7)-MAS receptor axis: More than regulation of blood pressure? Hypertension. 50:596–599. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Takada Y, Hiwada K, Yokoyama M, Ochi K, Takeuchi M and Kokubu T: Angiotensin converting enzyme. A possible histologic indicator for human renal cell carcinoma. Cancer. 56:130–133. 1985. View Article : Google Scholar : PubMed/NCBI

25 

Larrinaga G, Pérez I, Sanz B, Blanco L, López JI, Cándenas ML, Pinto FM, Gil J, Irazusta J and Varona A: Angiotensin-converting enzymes (ACE and ACE2) are downregulated in renal tumors. Regul Pept. 165:218–223. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Usmani BA, Janeczko M, Shen R, Mazumdar M, Papandreou CN and Nanus DM: Analysis of the insertion/deletion polymorphism of the human angiotensin converting enzyme (ACE) gene in patients with renal cancer. Br J Cancer. 82:550–552. 2000.PubMed/NCBI

27 

de Martino M, Klatte T, Schatzl G, Waldert M, Remzi M, Haitel A, Kramer G and Marberger M: Insertion/deletion polymorphism of angiotensin I-converting enzyme gene is linked with chromophobe renal cell carcinoma. Urology. 77:1005.e9–1005.e13. 2011. View Article : Google Scholar

28 

van der Knaap R, Siemes C, Coebergh JW, van Duijn CM, Hofman A and Stricker BH: Renin-angiotensin system inhibitors, angiotensin I-converting enzyme gene insertion/deletion polymorphism and cancer: The Rotterdam Study. Cancer. 112:748–757. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Deckers IA, van den Brandt PA, van Engeland M, van Schooten FJ, Godschalk RW, Keszei AP and Schouten LJ: Polymorphisms in genes of the renin-angiotensin-aldosterone system and renal cell cancer risk: Interplay with hypertension and intakes of sodium, potassium and fluid. Int J Cancer. 136:1104–1116. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Andreotti G, Boffetta P, Rosenberg PS, Berndt SI, Karami S, Menashe I, Yeager M, Chanock SJ, Zaridze D, Matteev V, et al: Variants in blood pressure genes and the risk of renal cell carcinoma. Carcinogenesis. 31:614–620. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Kohara K, Brosnihan KB and Ferrario CM: Angiotensin(1–7) in the spontaneously hypertensive rat. Peptides. 14:883–891. 1993. View Article : Google Scholar : PubMed/NCBI

32 

Zhu T, Miller AG, Deliyanti D, Berka DR, Agrotis A, Campbell DJ and Wilkinson-Berka JL: Prorenin stimulates a pro-angiogenic and pro-inflammatory response in retinal endothelial cells and an M1 phenotype in retinal microglia. Clin Exp Pharmacol Physiol. 42:537–548. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Shibayama Y, Fujimori T, Nguyen G, Hirose T, Totsune K, Ichihara A, Kitada K, Nakano D, Kobori H, Kohno M, et al: (Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma. Sci Rep. 5:88542015. View Article : Google Scholar : PubMed/NCBI

34 

Trask AJ and Ferrario CM: Angiotensin-(1–7): pharmacology and new perspectives in cardiovascular treatments. Cardiovasc Drug Rev. 25:162–174. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Yacoub R and Campbell KN: Inhibition of RAS in diabetic nephropathy. Int J Nephrol Renovasc Dis. 8:29–40. 2015.PubMed/NCBI

36 

Montana V and Sontheimer H: Bradykinin promotes the chemotactic invasion of primary brain tumors. J Neurosci. 31:4858–4867. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Williams RN, Parsons SL, Morris TM, Rowlands BJ and Watson SA: Inhibition of matrix metalloproteinase activity and growth of gastric adenocarcinoma cells by an angiotensin converting enzyme inhibitor in in vitro and murine models. Eur J Surg Oncol. 31:1042–1050. 2005. View Article : Google Scholar : PubMed/NCBI

38 

de Groot-Besseling RR, Ruers TJ, van Kraats AA, Poelen GJ, Ruiter DJ, de Waal RM and Westphal JR: Anti-tumor activity of a combination of plasminogen activator and captopril in a human melanoma xenograft model. Int J Cancer. 112:329–334. 2004. View Article : Google Scholar : PubMed/NCBI

39 

McMurray J and Chopra M: Influence of ACE inhibitors on free radicals and reperfusion injury: Pharmacological curiosity or therapeutic hope? Br J Clin Pharmacol. 31:373–379. 1991. View Article : Google Scholar : PubMed/NCBI

40 

Zheng S, Yang Y, Song R, Yang X, Liu H, Ma Q, Yang L, Meng R, Tao T, Wang S and He J: Ang-(1–7) promotes the migration and invasion of human renal cell carcinoma cells via Mas-mediated AKT signaling pathway. Biochem Biophys Res Commun. 460:333–340. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Esteban V, Heringer-Walther S, Sterner-Kock A, de Bruin R, van den Engel S, Wang Y, Mezzano S, Egido J, Schultheiss HP, Ruiz-Ortega M and Walther T: Angiotensin-(1–7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS One. 4:e54062009. View Article : Google Scholar : PubMed/NCBI

42 

Ni L, Feng Y, Wan H, Ma Q, Fan L, Qian Y, Li Q, Xiang Y and Gao B: Angiotensin-(1–7) inhibits the migration and invasion of A549 human lung adenocarcinoma cells through inactivation of the PI3K/Akt and MAPK signaling pathways. Oncol Rep. 27:783–790. 2012.PubMed/NCBI

43 

Soto-Pantoja DR, Menon J, Gallagher PE and Tallant EA: Angiotensin-(1–7) inhibits tumor angiogenesis in human lung cancer xenografts with a reduction in vascular endothelial growth factor. Mol Cancer Ther. 8:1676–1683. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Gallagher PE and Tallant EA: Inhibition of human lung cancer cell growth by angiotensin-(1–7). Carcinogenesis. 25:2045–2052. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Mukai H, Fitzgibbon WR, Bozeman G, Margolius HS and Ploth DW: Bradykinin B2 receptor antagonist increases chloride and water absorption in rat medullary collecting duct. Am J Physiol. 271:R352–R360. 1996.PubMed/NCBI

46 

Bagaté K, Grima M, Imbs JL, Jong WD, Helwig JJ and Barthelmebs M: Signal transduction pathways involved in kinin B(2) receptor-mediated vasodilation in the rat isolated perfused kidney. Br J Pharmacol. 132:1735–1742. 2001. View Article : Google Scholar : PubMed/NCBI

47 

El-Dahr SS, Dipp S and Baricos WH: Bradykinin stimulates the ERK->Elk-1->Fos/AP-1 pathway in mesangial cells. Am J Physiol. 275:F343–F352. 1998.PubMed/NCBI

48 

Moodley R, Snyman C, Odhav B and Bhoola KD: Visualisation of transforming growth factor-beta 1, tissue kallikrein, and kinin and transforming growth factor-beta receptors on human clear-cell renal carcinoma cells. Biol Chem. 386:375–382. 2005. View Article : Google Scholar : PubMed/NCBI

49 

Kramarenko II, Morinelli TA, Bunni MA, Raymond JR Sr and Garnovskaya MN: The bradykinin B(2) receptor induces multiple cellular responses leading to the proliferation of human renal carcinoma cell lines. Cancer Manag Res. 4:195–205. 2012.PubMed/NCBI

50 

Lever AF, Hole DJ, Gillis CR, McCallum IR, McInnes GT, MacKinnon PL, Meredith PA, Murray LS, Reid JL and Robertson JW: Do inhibitors of angiotensin-I-converting enzyme protect agains risk of cancer? Lancet. 352:179–184. 1998. View Article : Google Scholar : PubMed/NCBI

51 

Yoon C, Yang HS, Jeon I, Chang Y and Park SM: Use of angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers and cancer risk: A meta-analysis of observational studies. CMAJ. 183:E1073–E1084. 2011. View Article : Google Scholar : PubMed/NCBI

52 

Fryzek JP, Poulsen AH, Johnsen SP, McLaughlin JK, Sørensen HT and Friis S: A cohort study of antihypertensive treatments and risk of renal cell cancer. Br J Cancer. 92:1302–1306. 2005. View Article : Google Scholar : PubMed/NCBI

53 

Chin HJ, Oh SW, Goo HS, Oh J, Noh JW, Cho JT, Na KY, Kim S and Chae DW: Members of The PREMIER Group: Effect of RAAS inhibition on the incidence of cancer and cancer mortality in patients with glomerulonephritis. J Korean Med Sci. 26:59–66. 2011. View Article : Google Scholar : PubMed/NCBI

54 

Wysocki PJ, Kwiatkowska EP, Kazimierczak U, Suchorska W, Kowalczyk DW and Mackiewicz A: Captopril, an angiotensin-converting enzyme inhibitor, promotes growth of immunogenic tumors in mice. Clin Cancer Res. 12:4095–4102. 2006. View Article : Google Scholar : PubMed/NCBI

55 

Hii SI, Nicol DL, Gotley DC, Thompson LC, Green MK and Jonsson JR: Captopril inhibits tumour growth in a xenograft model of human renal cell carcinoma. Br J Cancer. 77:880–883. 1998. View Article : Google Scholar : PubMed/NCBI

56 

Araujo WF, Naves MA, Ravanini JN, Schor N and Teixeira VP: Renin-angiotensin system (RAS) blockade attenuates growth and metastatic potential of renal cell carcinoma in mice. Urol Oncol. 33:389.e1–e7. 2015. View Article : Google Scholar

57 

McKay RR, Rodriguez GE, Lin X, Kaymakcalan MD, Hamnvik OP, Sabbisetti VS, Bhatt RS, Simantov R and Choueiri TK: Angiotensin system inhibitors and survival outcomes in patients with metastatic renal cell carcinoma. Clin Cancer Res. 21:2471–2479. 2015. View Article : Google Scholar : PubMed/NCBI

58 

Tatokoro M, Fujii Y, Kawakami S, Saito K, Koga F, Matsuoka Y, Iimura Y, Masuda H and Kihara K: Phase-II trial of combination treatment of interferon-α, cimetidine, cyclooxygenase-2 inhibitor and renin-angiotensin-system inhibitor (I-CCA therapy) for advanced renal cell carcinoma. Cancer Sci. 102:137–143. 2011. View Article : Google Scholar : PubMed/NCBI

59 

Miyajima A, Yazawa S, Kosaka T, Tanaka N, Shirotake S, Mizuno R, Kikuchi E and Oya M: Prognostic impact of renin-angiotensin system blockade on renal cell carcinoma after surgery. Ann Surg Oncol. 22:3751–3759. 2015. View Article : Google Scholar : PubMed/NCBI

60 

Keizman D, Huang P, Eisenberger MA, Pili R, Kim JJ, Antonarakis ES, Hammers H and Carducci MA: Angiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: A retrospective examination. Eur J Cancer. 47:1955–1961. 2011. View Article : Google Scholar : PubMed/NCBI

61 

Izzedine H, Derosa L, Le Teuff G, Albiges L and Escudier B: Hypertension and angiotensin system inhibitors: Impact on outcome in sunitinib-treated patients for metastatic renal cell carcinoma. Ann Oncol. 26:1128–1133. 2015. View Article : Google Scholar : PubMed/NCBI

62 

Hamnvik OP, Choueiri TK, Turchin A, McKay RR, Goyal L, Davis M, Kaymakcalan MD and Williams JS: Clinical risk factors for the development of hypertension in patients treated with inhibitors of the VEGF signaling pathway. Cancer. 121:311–319. 2015. View Article : Google Scholar : PubMed/NCBI

63 

Sorich MJ, Kichenadasse G, Rowland A, Woodman RJ and Mangoni AA: Angiotensin system inhibitors and survival in patients with metastatic renal cell carcinoma treated with VEGF-targeted therapy: A pooled secondary analysis of clinical trials. Int J Cancer. 138:2293–2299. 2016. View Article : Google Scholar : PubMed/NCBI

64 

Penttila P, Rautiola J, Poussa T, Peltola K and Bono P: Angiotensin inhibitors as treatment of Sunitinib/Pazopanib-induced hypertension in metastatic renal cell carcinoma. Clin Genitourin Cancer. 15:384–390.e3. 2017. View Article : Google Scholar : PubMed/NCBI

65 

Huillard O, Xylinas E, Peyromaure M, Alexandre J and Goldwasser F: Angiotensin system inhibitors in renal cell carcinoma-letter. Clin Cancer Res. 22:5242016. View Article : Google Scholar : PubMed/NCBI

66 

Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, et al: Seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension. 42:1206–1252. 2003. View Article : Google Scholar : PubMed/NCBI

67 

Rini BI, Cohen DP, Lu DR, Chen I, Hariharan S, Gore ME, Figlin RA, Baum MS and Motzer RJ: Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib. J Natl Cancer Inst. 103:763–773. 2011. View Article : Google Scholar : PubMed/NCBI

68 

Robinson ES, Khankin EV, Choueiri TK, Dhawan MS, Rogers MJ, Karumanchi SA and Humphreys BD: Supression of the nitric oxide pathway in metastatic renal cell carcinoma patients receiving vascular endothelial growth factor-signaling inhibitors. Hypertension. 56:1131–1136. 2010. View Article : Google Scholar : PubMed/NCBI

69 

Gupta R and Maitland ML: Sunitinib, hypertension, and heart failure: A model for kinase inhibitor-mediated cardiotoxicity. Curr Hypertens Rep. 13:430–435. 2011. View Article : Google Scholar : PubMed/NCBI

70 

Kappers MH, van Esch JH, Sluiter W, Sleijfer S, Danser AH and van den Meiracker AH: Hypertension induced by the tyrosine kinase inhibitor sunitinib is associated with increased circulating endothelin-1 levels. Hypertension. 56:675–681. 2010. View Article : Google Scholar : PubMed/NCBI

71 

Veronese ML, Mosenkis A, Flaherty KT, Gallagher M, Stevenson JP, Townsend RR and O'Dwyer PJ: Mechanisms of hypertension associated with BAY 43–9006. J Clin Oncol. 24:1363–1369. 2006. View Article : Google Scholar : PubMed/NCBI

72 

Curwen JO, Musgrove HL, Kendrew J, Richmond GH, Ogilvie DJ and Wedge SR: Inhibition of vascular endothelial growth factor-a signaling induces hypertension: Examining the effect of cediranib (recentin; AZD2171) treatment on blood pressure in rat and the use of concomitant antihypertensive therapy. Clin Cancer Res. 14:3124–3131. 2008. View Article : Google Scholar : PubMed/NCBI

73 

Siddiqui AJ, Mansson-Broberg A, Gustafsson T, Grinnemo KH, Dellgren G, Hao X, Fischer H and Sylvén C: Antagonism of the renin-angiotensin system can counteracts cardiac angiogenic vascular endothelial growth factor gene therapy and myocardial angiogenesis in normal heart. Am J Hyprtens. 18:1347–1352. 2005. View Article : Google Scholar

74 

Agabiti-Rosei E: Structural and functional changes of the microcirculation in hypertension: Influence of pharmacological therapy. Drugs. 63:19–29. 2003.(In French). View Article : Google Scholar : PubMed/NCBI

75 

Szmit S, Langiewicz P, Zlnierek J, Nurzyński P, Zaborowska M, Filipiak KJ, Opolski G and Szczylik C: Hypertension as a predictive factor for survival outcomes in patients with metastatic renal cell carcinoma treated with sunitinib after progression on cytokines. Kidney Blood Press Res. 35:18–25. 2012. View Article : Google Scholar : PubMed/NCBI

76 

Zhu X, Stergiopoulos K and Wu S: Risk of hypertension and renal dysfunction with an angiogenesis inhibitor sunitinib: Systematic review and meta-analysis. Acta Oncol. 48:9–17. 2009. View Article : Google Scholar : PubMed/NCBI

77 

Nagasawa T, Khan Hye MA and Imig JD: Captopril attenuates hypertension and renal injury induced by the vascular endothelial growth factor inhibitor sorafenib. Clin Exp Pharmacol Physiol. 39:454–461. 2012. View Article : Google Scholar : PubMed/NCBI

78 

Lankhorst S, Kappers MH, van Esch JH, Smedts FM, Sleijfer S, Mathijssen RH, Baelde HJ, Danser AH and van den Meiracker AH: Treatment of hypertension and renal injury induced by the angiogenesis inhibitor sunitinib: Preclinical study. Hypertension. 64:1282–1289. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sobczuk P, Szczylik C, Porta C and Czarnecka AM: Renin angiotensin system deregulation as renal cancer risk factor (Review). Oncol Lett 14: 5059-5068, 2017.
APA
Sobczuk, P., Szczylik, C., Porta, C., & Czarnecka, A.M. (2017). Renin angiotensin system deregulation as renal cancer risk factor (Review). Oncology Letters, 14, 5059-5068. https://doi.org/10.3892/ol.2017.6826
MLA
Sobczuk, P., Szczylik, C., Porta, C., Czarnecka, A. M."Renin angiotensin system deregulation as renal cancer risk factor (Review)". Oncology Letters 14.5 (2017): 5059-5068.
Chicago
Sobczuk, P., Szczylik, C., Porta, C., Czarnecka, A. M."Renin angiotensin system deregulation as renal cancer risk factor (Review)". Oncology Letters 14, no. 5 (2017): 5059-5068. https://doi.org/10.3892/ol.2017.6826
Copy and paste a formatted citation
x
Spandidos Publications style
Sobczuk P, Szczylik C, Porta C and Czarnecka AM: Renin angiotensin system deregulation as renal cancer risk factor (Review). Oncol Lett 14: 5059-5068, 2017.
APA
Sobczuk, P., Szczylik, C., Porta, C., & Czarnecka, A.M. (2017). Renin angiotensin system deregulation as renal cancer risk factor (Review). Oncology Letters, 14, 5059-5068. https://doi.org/10.3892/ol.2017.6826
MLA
Sobczuk, P., Szczylik, C., Porta, C., Czarnecka, A. M."Renin angiotensin system deregulation as renal cancer risk factor (Review)". Oncology Letters 14.5 (2017): 5059-5068.
Chicago
Sobczuk, P., Szczylik, C., Porta, C., Czarnecka, A. M."Renin angiotensin system deregulation as renal cancer risk factor (Review)". Oncology Letters 14, no. 5 (2017): 5059-5068. https://doi.org/10.3892/ol.2017.6826
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