The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells

  • Authors:
    • Patricia Adamo
    • Sean Porazinski
    • Shavanthi Rajatileka
    • Samantha Jumbe
    • Rachel Hagen
    • Man‑Kim Cheung
    • Ian Wilson
    • Michael R. Ladomery
  • View Affiliations

  • Published online on: August 28, 2017     https://doi.org/10.3892/ol.2017.6841
  • Pages:5605-5610
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Abstract

The oncogene ETS‑related gene (ERG) encodes a transcription factor with roles in the regulation of haematopoiesis, angiogenesis, vasculogenesis, inflammation, migration and invasion. The ERG oncogene is activated in >50% of prostate cancer cases, generally through a gene fusion with the androgen‑responsive promoter of transmembrane protease serine 2. Phosphatase and tensin homologue (PTEN) is an important tumour suppressor gene that is often inactivated in cancer. ERG overexpression combined with PTEN inactivation or loss is often associated with aggressive prostate cancer. The present study aimed to determine whether or not ERG regulates PTEN transcription directly. ERG was demonstrated to bind to the PTEN promoter and repress its transcription. ERG overexpression reduced endogenous PTEN expression, whereas ERG knockdown increased PTEN expression. The ability of ERG to repress PTEN may contribute to a more cancer‑permissive environment.

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November 2017
Volume 14 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Adamo, P., Porazinski, S., Rajatileka, S., Jumbe, S., Hagen, R., Cheung, M. ... Ladomery, M.R. (2017). The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells. Oncology Letters, 14, 5605-5610. https://doi.org/10.3892/ol.2017.6841
MLA
Adamo, P., Porazinski, S., Rajatileka, S., Jumbe, S., Hagen, R., Cheung, M., Wilson, I., Ladomery, M. R."The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells". Oncology Letters 14.5 (2017): 5605-5610.
Chicago
Adamo, P., Porazinski, S., Rajatileka, S., Jumbe, S., Hagen, R., Cheung, M., Wilson, I., Ladomery, M. R."The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells". Oncology Letters 14, no. 5 (2017): 5605-5610. https://doi.org/10.3892/ol.2017.6841