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Lumican expression in gastric cancer and its association with biological behavior and prognosis

  • Authors:
    • Li Chen
    • Yuxin Zhang
    • Yanjiao Zuo
    • Fei Ma
    • Hongjiang Song
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China, Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5235-5240
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    Published online on: August 28, 2017
       https://doi.org/10.3892/ol.2017.6842
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Abstract

The aim of the present study was to investigate the expression of lumican in human gastric cancer and adjacent normal gastric tissues, and study its association with clinicopathological characteristics and survival rate. By using immunohistochemistry, the lumican expression patterns in 146 cases of gastric cancer with various clinicopathological characteristics 55 adjacent normal gastric tissue specimens was studied. And the significance of lumican expression regarding the biological behavior and survival of patients was evaluated. In adjacent normal gastric tissues, lumican was expressed weakly in 10.9% (6/55) of samples. By contrast, the lumican expression rate was 66.4% (97/146) in gastric cancer tissues. Lumican protein expression was closely associated with organ metastasis, lymphatic metastasis and histological type (P<0.05), but not with the tumor location, size, invasion depth or Borrmann type (P>0.05). The median survival time in patients with negative, weakly positive and strongly positive lumican expression was 46.3, 39.6 and 24.3 months, respectively (χ2=8.492; P=0.014). There was a significant association between lumican expression and invasive potential in gastric cancer; therefore, lumican may represent an independent prognostic factor.
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Copy and paste a formatted citation
Spandidos Publications style
Chen L, Zhang Y, Zuo Y, Ma F and Song H: Lumican expression in gastric cancer and its association with biological behavior and prognosis. Oncol Lett 14: 5235-5240, 2017.
APA
Chen, L., Zhang, Y., Zuo, Y., Ma, F., & Song, H. (2017). Lumican expression in gastric cancer and its association with biological behavior and prognosis. Oncology Letters, 14, 5235-5240. https://doi.org/10.3892/ol.2017.6842
MLA
Chen, L., Zhang, Y., Zuo, Y., Ma, F., Song, H."Lumican expression in gastric cancer and its association with biological behavior and prognosis". Oncology Letters 14.5 (2017): 5235-5240.
Chicago
Chen, L., Zhang, Y., Zuo, Y., Ma, F., Song, H."Lumican expression in gastric cancer and its association with biological behavior and prognosis". Oncology Letters 14, no. 5 (2017): 5235-5240. https://doi.org/10.3892/ol.2017.6842
Copy and paste a formatted citation
x
Spandidos Publications style
Chen L, Zhang Y, Zuo Y, Ma F and Song H: Lumican expression in gastric cancer and its association with biological behavior and prognosis. Oncol Lett 14: 5235-5240, 2017.
APA
Chen, L., Zhang, Y., Zuo, Y., Ma, F., & Song, H. (2017). Lumican expression in gastric cancer and its association with biological behavior and prognosis. Oncology Letters, 14, 5235-5240. https://doi.org/10.3892/ol.2017.6842
MLA
Chen, L., Zhang, Y., Zuo, Y., Ma, F., Song, H."Lumican expression in gastric cancer and its association with biological behavior and prognosis". Oncology Letters 14.5 (2017): 5235-5240.
Chicago
Chen, L., Zhang, Y., Zuo, Y., Ma, F., Song, H."Lumican expression in gastric cancer and its association with biological behavior and prognosis". Oncology Letters 14, no. 5 (2017): 5235-5240. https://doi.org/10.3892/ol.2017.6842
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