Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Curcumin inhibits MCF‑7 cells by modulating the NF‑κB signaling pathway

  • Authors:
    • Jun‑Li Liu
    • Yan‑Yan Pan
    • Ou Chen
    • Yun Luan
    • Xia Xue
    • Jing‑Jie Zhao
    • Ling Liu
    • Hong‑Ying Jia
  • View Affiliations / Copyright

    Affiliations: Clinical Molecular Biology Laboratory, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China, Department of Pediatrics, Qilu Children's Hospital of Shandong University, Jinan, Shandong 066600, P.R. China, College of Nursing, Shandong University, Jinan, Shandong 250014, P.R. China, Central Research Laboratory, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China, Department of Pharmacy, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China, Center of Evidence‑Based Medicine, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China
  • Pages: 5581-5584
    |
    Published online on: August 31, 2017
       https://doi.org/10.3892/ol.2017.6860
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study investigated the inhibitory effect of curcumin on human breast cancer MCF‑7 cells and investigated the potential underlying molecular mechanisms. MCF‑7 cells were cultured with curcumin at different concentrations and time points. The effects of curcumin treatment on breast cancer cell proliferation were studied using a MTT assay. Reverse transcription‑quantitative polymerase chain reaction and western blot analysis were used to assess the mRNA and protein expression levels of B‑cell lymphoma 2 (Bcl‑2) and Bcl‑2‑associated X (Bax), nuclear factor‑κ‑light‑chain‑enhancer of activated B cells (NF‑κB) and inhibitor of NF‑κB‑α (IκBα). The proliferation of MCF‑7 cells in the group treated with curcumin was markedly decreased compared with the control, with the greatest inhibitory effect at a concentration of 20 µM. The expression of Bax mRNA was increased and Bcl‑2 mRNA expression was decreased compared with the control. Additionally, protein expression of NF‑κB and IκB was increased. The data indicate that curcumin is able to inhibit breast cancer cell proliferation, possibly by regulating the NF‑κB signaling pathway.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Pu Z, Yuan X, Zhang X, Chen Q and Xie H: Meta-analysis on the association between CYP2D6*10 gene polymorphism and disease free survival of breast cancer patients receiving tamoxifen treatment in Asia. Bangladesh J Pharmacol. 9:652–662. 2014. View Article : Google Scholar

2 

Li Z and Kang Y: Emerging therapeutic targets in metastatic progression: A focus on breast cancer. Pharmacol Ther. 161:79–96. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Chung SS and Vadgama JV: Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFκB signaling. Anticancer Res. 35:39–46. 2015.PubMed/NCBI

4 

Ramachandran C and You W: Differential sensitivity of human mammary epithelial and breast carcinoma cell lines to curcumin. Breast Cancer Res Treat. 54:269–278. 1999. View Article : Google Scholar : PubMed/NCBI

5 

Li YB, Gao JL, Zhong ZF, Hoi PM, Lee SM and Wang YT: Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways. Pharmacol Rep. 65:700–709. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Ramachandran C, Rodriguez S, Ramachandran R, Nair Raveendran PK, Fonseca H, Khatib Z, Escalon E and Melnick SJ: Expression profiles of apoptotic genes induced by curcumin in human breast cancer and mammary epithelial cell lines. Anticancer Res. 25:3293–3302. 2005.PubMed/NCBI

7 

Basnet P and Skalko-Basnet N: Curcumin: An anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules. 16:4567–4598. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Chen Y, Shu W, Chen W, Wu Q, Liu H and Cui G: Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells. Basic Clin Pharmacol Toxicol. 101:427–433. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Goel A, Kunnumakkara AB and Aggarwal BB: Curcumin as ‘Curecumin’: from kitchen to clinic. Biochem Pharmacol. 75:787–809. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Wang Y, Yu J, Cui R, Lin J and Ding X: Curcumin in treating breast cancer: A review. J Lab Autom. 21:723–731. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Hatcher H, Planalp R, Cho J, Torti FM and Torti SV: Curcumin: From ancient medicine to current clinical trials. Cell Mol Life Sci. 65:1631–1652. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Lin YG, Kunnumakkara AB, Nair A, Merritt WM, Han LY, Armaiz-Pena GN, Kamat AA, Spannuth WA, Gershenson DM, Lutgendorf SK, et al: Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway. Clin Cancer Res. 13:3423–3430. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Rengarajan T, Nandakumar N, Rajendran P, Haribabu L, Nishigaki I and Balasubramanian MP: D-pinitol promotes apoptosis in MCF-7 cells via induction of p53 and Bax and inhibition of Bcl-2 and NF-κB. Asian Pac J Cancer Prev. 15:1757–1762. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Kim KC, Baek SH and Lee C: Curcumin-induced downregulation of Axl receptor tyrosine kinase inhibits cell proliferation and circumvents chemoresistance in non-small lung cancer cells. Int J Oncol. 47:2296–2303. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Zhou X, Su J, Feng S, Wang L, Yin X, Yan J and Wang Z: Antitumor activity of curcumin is involved in down-regulation of YAP/TAZ expression in pancreatic cancer cells. Oncotarget. 7:79076–79088. 2016.PubMed/NCBI

18 

Sha J, Li J, Wang W, Pan L, Cheng J, Li L, Zhao H and Lin W: Curcumin induces G0/G1 arrest and apoptosis in hormone independent prostate cancer DU-145 cells by down regulating Notch signaling. Biomed Pharmacother. 84:177–184. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Iqbal B, Ghildiyal A, Sahabjada, Singh S, Arshad M, Mahdi AA and Tiwari S: Antiproliferative and apoptotic effect of curcumin and TRAIL (TNF Related Apoptosis inducing Ligand) in chronic myeloid leukaemic cells. J Clin Diagn Res. 10:XC01–XC05. 2016.PubMed/NCBI

20 

Somasundaram S, Edmund NA, Moore DT, Small GW, Shi YY and Orlowski RZ: Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Res. 62:3868–3875. 2002.PubMed/NCBI

21 

Tor YS, Yazan LS, Foo JB, Armania N, Cheah YK, Abdullah R, Imam MU, Ismail N and Ismail M: Induction of apoptosis through oxidative stress-related pathways in MCF-7, human breast cancer cells, by ethyl acetate extract of Dillenia suffruticosa. BMC Complement Altern Med. 14:552014. View Article : Google Scholar : PubMed/NCBI

22 

Oida K, Matsuda A, Jung K, Xia Y, Jang H, Amagai Y, Ahn G, Nishikawa S, Ishizaka S, Jensen-Jarolim E, et al: Nuclear factor-ĸB plays a critical role in both intrinsic and acquired resistance against endocrine therapy in human breast cancer cells. Sci Rep. 4:40572014. View Article : Google Scholar : PubMed/NCBI

23 

Colomer C, Marruecos L, Vert A, Bigas A and Espinosa L: NF-κB members left home: NF-κB-independent roles in cancer. biomedicines. 5:pii: E26. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Ghosh S, May MJ and Kopp EB: NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses. Annu Rev Immunol. 16:225–260. 1998. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu JL, Pan YY, Chen O, Luan Y, Xue X, Zhao JJ, Liu L and Jia HY: Curcumin inhibits MCF‑7 cells by modulating the NF‑κB signaling pathway. Oncol Lett 14: 5581-5584, 2017.
APA
Liu, J., Pan, Y., Chen, O., Luan, Y., Xue, X., Zhao, J. ... Jia, H. (2017). Curcumin inhibits MCF‑7 cells by modulating the NF‑κB signaling pathway. Oncology Letters, 14, 5581-5584. https://doi.org/10.3892/ol.2017.6860
MLA
Liu, J., Pan, Y., Chen, O., Luan, Y., Xue, X., Zhao, J., Liu, L., Jia, H."Curcumin inhibits MCF‑7 cells by modulating the NF‑κB signaling pathway". Oncology Letters 14.5 (2017): 5581-5584.
Chicago
Liu, J., Pan, Y., Chen, O., Luan, Y., Xue, X., Zhao, J., Liu, L., Jia, H."Curcumin inhibits MCF‑7 cells by modulating the NF‑κB signaling pathway". Oncology Letters 14, no. 5 (2017): 5581-5584. https://doi.org/10.3892/ol.2017.6860
Copy and paste a formatted citation
x
Spandidos Publications style
Liu JL, Pan YY, Chen O, Luan Y, Xue X, Zhao JJ, Liu L and Jia HY: Curcumin inhibits MCF‑7 cells by modulating the NF‑κB signaling pathway. Oncol Lett 14: 5581-5584, 2017.
APA
Liu, J., Pan, Y., Chen, O., Luan, Y., Xue, X., Zhao, J. ... Jia, H. (2017). Curcumin inhibits MCF‑7 cells by modulating the NF‑κB signaling pathway. Oncology Letters, 14, 5581-5584. https://doi.org/10.3892/ol.2017.6860
MLA
Liu, J., Pan, Y., Chen, O., Luan, Y., Xue, X., Zhao, J., Liu, L., Jia, H."Curcumin inhibits MCF‑7 cells by modulating the NF‑κB signaling pathway". Oncology Letters 14.5 (2017): 5581-5584.
Chicago
Liu, J., Pan, Y., Chen, O., Luan, Y., Xue, X., Zhao, J., Liu, L., Jia, H."Curcumin inhibits MCF‑7 cells by modulating the NF‑κB signaling pathway". Oncology Letters 14, no. 5 (2017): 5581-5584. https://doi.org/10.3892/ol.2017.6860
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team