Curcumin inhibits MCF‑7 cells by modulating the NF‑κB signaling pathway

  • Authors:
    • Jun‑Li Liu
    • Yan‑Yan Pan
    • Ou Chen
    • Yun Luan
    • Xia Xue
    • Jing‑Jie Zhao
    • Ling Liu
    • Hong‑Ying Jia
  • View Affiliations

  • Published online on: August 31, 2017     https://doi.org/10.3892/ol.2017.6860
  • Pages: 5581-5584
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Abstract

The present study investigated the inhibitory effect of curcumin on human breast cancer MCF‑7 cells and investigated the potential underlying molecular mechanisms. MCF‑7 cells were cultured with curcumin at different concentrations and time points. The effects of curcumin treatment on breast cancer cell proliferation were studied using a MTT assay. Reverse transcription‑quantitative polymerase chain reaction and western blot analysis were used to assess the mRNA and protein expression levels of B‑cell lymphoma 2 (Bcl‑2) and Bcl‑2‑associated X (Bax), nuclear factor‑κ‑light‑chain‑enhancer of activated B cells (NF‑κB) and inhibitor of NF‑κB‑α (IκBα). The proliferation of MCF‑7 cells in the group treated with curcumin was markedly decreased compared with the control, with the greatest inhibitory effect at a concentration of 20 µM. The expression of Bax mRNA was increased and Bcl‑2 mRNA expression was decreased compared with the control. Additionally, protein expression of NF‑κB and IκB was increased. The data indicate that curcumin is able to inhibit breast cancer cell proliferation, possibly by regulating the NF‑κB signaling pathway.

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November 2017
Volume 14 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Liu, J., Pan, Y., Chen, O., Luan, Y., Xue, X., Zhao, J. ... Jia, H. (2017). Curcumin inhibits MCF‑7 cells by modulating the NF‑κB signaling pathway. Oncology Letters, 14, 5581-5584. https://doi.org/10.3892/ol.2017.6860
MLA
Liu, J., Pan, Y., Chen, O., Luan, Y., Xue, X., Zhao, J., Liu, L., Jia, H."Curcumin inhibits MCF‑7 cells by modulating the NF‑κB signaling pathway". Oncology Letters 14.5 (2017): 5581-5584.
Chicago
Liu, J., Pan, Y., Chen, O., Luan, Y., Xue, X., Zhao, J., Liu, L., Jia, H."Curcumin inhibits MCF‑7 cells by modulating the NF‑κB signaling pathway". Oncology Letters 14, no. 5 (2017): 5581-5584. https://doi.org/10.3892/ol.2017.6860