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Negative correlation between X‑linked inhibitors of apoptosis and second mitochondria‑derived activator of caspase expression levels in cervical carcinoma and cervical intraepithelial neoplasia

  • Authors:
    • Xue‑Jing Jin
    • Ping‑Sheng Cai
    • Shu‑Pin Zhu
    • Li‑Jie Wang
    • Hua Zhu
  • View Affiliations / Copyright

    Affiliations: Departments of Obstetrics and Gynecology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, Zhejiang 325000, P.R. China, Departments of Obstetrics and Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
    Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5340-5346
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    Published online on: September 4, 2017
       https://doi.org/10.3892/ol.2017.6878
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Abstract

X‑linked inhibitors of apoptosis (XIAP) and second mitochondria‑derived activator of caspase (Smac) have been widely reported to serve roles in the development of cervical carcinoma. The present study analyzed the associations between the expression levels of XIAP and Smac in normal cervical epithelium, cervical intraepithelial neoplasia (CIN) and cervical carcinoma. Immunohistochemistry staining of formalin‑fixed, paraffin‑embedded tissue sections was performed in order to analyze the expression levels of XIAP and Smac in 15 cases of normal cervical tissues, 69 cases of CIN and 76 cases of cervical carcinoma. All the tissue samples were confirmed by pathological diagnosis. The association of XIAP and Smac expression levels was analyzed using one‑way analysis of variance, χ2 tests and Spearman's ρ for the nonparametric bi‑variant correlation analysis. Overall survival was determined using the log‑rank test and Kaplan‑Meier survival curves. The expression level of XIAP was increased in CIN and cervical carcinoma tissues compared with normal cervical tissues, whereas Smac demonstrated a converse expression pattern to XIAP in these tissues. The positive staining level of XIAP protein was increased in grade 3 CIN compared with that in grade 1‑2 CIN, and was significantly higher in the less‑differentiated tissue of cervical carcinoma compared with the well‑ or medium‑differentiated tissues (P<0.05). The staining level was also significantly increased in cervical carcinoma with stage 2b‑3 compared with tissues from stage 1‑2a carcinoma (P<0.05). The expression levels of Smac were in opposition to these results. XIAP was associated with pelvic lymph node metastasis, whereas no association was identified with Smac expression. The expression level of XIAP was significantly and negatively associated with cell survival time in cervical carcinoma, whereas the expression level of Smac was significantly and positively associated with cell survival time in cervical carcinoma. Therefore, XIAP and Smac may participate in the development of cervical cancer. The expression levels of XIAP and Smac were significantly and inversely associated. This may be useful in early diagnosis, evaluation of surgery and chemotherapy and the prognosis of cervical carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Jin XJ, Cai PS, Zhu SP, Wang LJ and Zhu H: Negative correlation between X‑linked inhibitors of apoptosis and second mitochondria‑derived activator of caspase expression levels in cervical carcinoma and cervical intraepithelial neoplasia. Oncol Lett 14: 5340-5346, 2017.
APA
Jin, X., Cai, P., Zhu, S., Wang, L., & Zhu, H. (2017). Negative correlation between X‑linked inhibitors of apoptosis and second mitochondria‑derived activator of caspase expression levels in cervical carcinoma and cervical intraepithelial neoplasia. Oncology Letters, 14, 5340-5346. https://doi.org/10.3892/ol.2017.6878
MLA
Jin, X., Cai, P., Zhu, S., Wang, L., Zhu, H."Negative correlation between X‑linked inhibitors of apoptosis and second mitochondria‑derived activator of caspase expression levels in cervical carcinoma and cervical intraepithelial neoplasia". Oncology Letters 14.5 (2017): 5340-5346.
Chicago
Jin, X., Cai, P., Zhu, S., Wang, L., Zhu, H."Negative correlation between X‑linked inhibitors of apoptosis and second mitochondria‑derived activator of caspase expression levels in cervical carcinoma and cervical intraepithelial neoplasia". Oncology Letters 14, no. 5 (2017): 5340-5346. https://doi.org/10.3892/ol.2017.6878
Copy and paste a formatted citation
x
Spandidos Publications style
Jin XJ, Cai PS, Zhu SP, Wang LJ and Zhu H: Negative correlation between X‑linked inhibitors of apoptosis and second mitochondria‑derived activator of caspase expression levels in cervical carcinoma and cervical intraepithelial neoplasia. Oncol Lett 14: 5340-5346, 2017.
APA
Jin, X., Cai, P., Zhu, S., Wang, L., & Zhu, H. (2017). Negative correlation between X‑linked inhibitors of apoptosis and second mitochondria‑derived activator of caspase expression levels in cervical carcinoma and cervical intraepithelial neoplasia. Oncology Letters, 14, 5340-5346. https://doi.org/10.3892/ol.2017.6878
MLA
Jin, X., Cai, P., Zhu, S., Wang, L., Zhu, H."Negative correlation between X‑linked inhibitors of apoptosis and second mitochondria‑derived activator of caspase expression levels in cervical carcinoma and cervical intraepithelial neoplasia". Oncology Letters 14.5 (2017): 5340-5346.
Chicago
Jin, X., Cai, P., Zhu, S., Wang, L., Zhu, H."Negative correlation between X‑linked inhibitors of apoptosis and second mitochondria‑derived activator of caspase expression levels in cervical carcinoma and cervical intraepithelial neoplasia". Oncology Letters 14, no. 5 (2017): 5340-5346. https://doi.org/10.3892/ol.2017.6878
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