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The role of LASS2 in regulating bladder cancer cell tumorigenicity in a nude mouse model

  • Authors:
    • Yujin Chen
    • Haifeng Wang
    • Tao Xiong
    • Renchao Zou
    • Zhaoran Tang
    • Jiansong Wang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Yunnan Institute of Urology, Kunming, Yunnan 650101, P.R. China, Department of Cadre Medical Care, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650031, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5149-5156
    |
    Published online on: September 4, 2017
       https://doi.org/10.3892/ol.2017.6880
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Abstract

Previous in vitro studies have demonstrated that LAG1 longevity assurance homolog 2 (LASS2) is a novel tumor suppressor gene that is significantly associated with the proliferation and invasion ability of tumor cells. However, the role LASS2 serves in regulating bladder cancer cell tumorigenicity and tumor growth in vivo has not yet been elucidated in animal or clinical studies. In the present study, LASS2 knockdown in human bladder cancer EJ‑M3 cells significantly promoted the growth of xenografts in nude mice compared with the control group, while overexpression of LASS2 suppressed tumor growth; however, this was not statistically significant. Furthermore, LASS2 knockdown resulted in more apparent heteromorphism and a higher activity of matrix metalloproteinase (MMP)‑2 and MMP‑9 in xenograft tumors. The data from the present study demonstrated that LASS2 knockdown significantly promoted the tumorigenicity and growth of EJ‑M3 xenograft tumors in nude mice, and that LASS2 overexpression has a tendency to inhibit the growth of xenografts, suggesting that it may be a potential therapeutic target for bladder cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Chen Y, Wang H, Xiong T, Zou R, Tang Z and Wang J: The role of LASS2 in regulating bladder cancer cell tumorigenicity in a nude mouse model. Oncol Lett 14: 5149-5156, 2017.
APA
Chen, Y., Wang, H., Xiong, T., Zou, R., Tang, Z., & Wang, J. (2017). The role of LASS2 in regulating bladder cancer cell tumorigenicity in a nude mouse model. Oncology Letters, 14, 5149-5156. https://doi.org/10.3892/ol.2017.6880
MLA
Chen, Y., Wang, H., Xiong, T., Zou, R., Tang, Z., Wang, J."The role of LASS2 in regulating bladder cancer cell tumorigenicity in a nude mouse model". Oncology Letters 14.5 (2017): 5149-5156.
Chicago
Chen, Y., Wang, H., Xiong, T., Zou, R., Tang, Z., Wang, J."The role of LASS2 in regulating bladder cancer cell tumorigenicity in a nude mouse model". Oncology Letters 14, no. 5 (2017): 5149-5156. https://doi.org/10.3892/ol.2017.6880
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Y, Wang H, Xiong T, Zou R, Tang Z and Wang J: The role of LASS2 in regulating bladder cancer cell tumorigenicity in a nude mouse model. Oncol Lett 14: 5149-5156, 2017.
APA
Chen, Y., Wang, H., Xiong, T., Zou, R., Tang, Z., & Wang, J. (2017). The role of LASS2 in regulating bladder cancer cell tumorigenicity in a nude mouse model. Oncology Letters, 14, 5149-5156. https://doi.org/10.3892/ol.2017.6880
MLA
Chen, Y., Wang, H., Xiong, T., Zou, R., Tang, Z., Wang, J."The role of LASS2 in regulating bladder cancer cell tumorigenicity in a nude mouse model". Oncology Letters 14.5 (2017): 5149-5156.
Chicago
Chen, Y., Wang, H., Xiong, T., Zou, R., Tang, Z., Wang, J."The role of LASS2 in regulating bladder cancer cell tumorigenicity in a nude mouse model". Oncology Letters 14, no. 5 (2017): 5149-5156. https://doi.org/10.3892/ol.2017.6880
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