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Review Open Access

Role of galectins in lung cancer (Review)

  • Authors:
    • Wei‑An Chang
    • Ming‑Ju Tsai
    • Po‑Lin Kuo
    • Jen‑Yu Hung
  • View Affiliations / Copyright

    Affiliations: Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C., Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, R.O.C.
    Copyright: © Chang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5077-5084
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    Published online on: September 4, 2017
       https://doi.org/10.3892/ol.2017.6882
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Abstract

Lung cancer is the leading cause of cancer‑associated mortality worldwide and is also associated with a poor prognosis. As in numerous other types of cancer, galectins have been demonstrated to be involved in the progression of lung cancer. Galectins belong to a superfamily of lectins, which are carbohydrate‑binding proteins. There are at least 15 members in the galectin family, however, only galectin‑1, ‑2, ‑3, ‑4, ‑7, ‑8, ‑9, ‑10, ‑12, and ‑13 are found in humans. Galectins are able to mediate interactions between cells, including homotypic and heterotypic interactions; they also facilitate the bindings between cells and extracellular matrix components. These cell‑cell and cell‑matrix interactions, as well as the galectin signaling on the cell surface, are able to modulate signaling pathways and thereby influence cellular functions and behaviors. Galectin‑1, ‑3, ‑4, ‑7, ‑8 and ‑9 are associated with lung cancer. These galectins are associated with tumor invasion, migration, metastasis and progression, and may serve important roles in the tumor microenvironment of lung cancer. The majority of galectins are associated with the progression of lung cancer, with the exception of galectin‑9, which is associated with enhanced anticancer immunity. Therefore, galectins may be potential targets for developing novel lung cancer therapies.
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Copy and paste a formatted citation
Spandidos Publications style
Chang WA, Tsai MJ, Kuo PL and Hung JY: Role of galectins in lung cancer (Review). Oncol Lett 14: 5077-5084, 2017.
APA
Chang, W., Tsai, M., Kuo, P., & Hung, J. (2017). Role of galectins in lung cancer (Review). Oncology Letters, 14, 5077-5084. https://doi.org/10.3892/ol.2017.6882
MLA
Chang, W., Tsai, M., Kuo, P., Hung, J."Role of galectins in lung cancer (Review)". Oncology Letters 14.5 (2017): 5077-5084.
Chicago
Chang, W., Tsai, M., Kuo, P., Hung, J."Role of galectins in lung cancer (Review)". Oncology Letters 14, no. 5 (2017): 5077-5084. https://doi.org/10.3892/ol.2017.6882
Copy and paste a formatted citation
x
Spandidos Publications style
Chang WA, Tsai MJ, Kuo PL and Hung JY: Role of galectins in lung cancer (Review). Oncol Lett 14: 5077-5084, 2017.
APA
Chang, W., Tsai, M., Kuo, P., & Hung, J. (2017). Role of galectins in lung cancer (Review). Oncology Letters, 14, 5077-5084. https://doi.org/10.3892/ol.2017.6882
MLA
Chang, W., Tsai, M., Kuo, P., Hung, J."Role of galectins in lung cancer (Review)". Oncology Letters 14.5 (2017): 5077-5084.
Chicago
Chang, W., Tsai, M., Kuo, P., Hung, J."Role of galectins in lung cancer (Review)". Oncology Letters 14, no. 5 (2017): 5077-5084. https://doi.org/10.3892/ol.2017.6882
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