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Article

Function of the macrophage‑capping protein in colorectal carcinoma

  • Authors:
    • Wei Wu
    • Jingdi Chen
    • Qianshan Ding
    • Sheng Yang
    • Jianping Wang
    • Honggang Yu
    • Jun Lin
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China, 73rd Contingent, 95969 Troops, The Airborne Force of Chinese PLA, Wuhan, Hubei 430300, P.R. China, Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China
  • Pages: 5549-5555
    |
    Published online on: September 6, 2017
       https://doi.org/10.3892/ol.2017.6888
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Abstract

To investigate the role of macrophage‑capping protein (CapG) in the development and progression of colorectal carcinoma (CRC), immunohistochemistry (IHC), Kaplan‑Meier survival analysis, wound healing and Transwell migration assays were performed. The IHC results demonstrated that CapG was relatively highly expressed in CRC tissue compared with non‑tumor tissue (P<0.001), and that the expression of CapG was significantly associated with the tumor site, differentiation, lymph node metastasis and clinical stage (P=0.021, P=0.036, P=0.012 and P=0.009, respectively). Wound healing and Transwell migration assays demonstrated that the reduction of CapG expression in a CRC cell line by RNA interference was associated with significantly impaired motility (P<0.001). Kaplan‑Meier survival analysis revealed that the expression of CapG in tumor samples was not significantly associated with disease‑free survival time. In conclusion, CapG was overexpressed in CRC and was associated with tumor progression; therefore, it may be a useful prognostic biomarker and therapeutic target in CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Wu W, Chen J, Ding Q, Yang S, Wang J, Yu H and Lin J: Function of the macrophage‑capping protein in colorectal carcinoma. Oncol Lett 14: 5549-5555, 2017.
APA
Wu, W., Chen, J., Ding, Q., Yang, S., Wang, J., Yu, H., & Lin, J. (2017). Function of the macrophage‑capping protein in colorectal carcinoma. Oncology Letters, 14, 5549-5555. https://doi.org/10.3892/ol.2017.6888
MLA
Wu, W., Chen, J., Ding, Q., Yang, S., Wang, J., Yu, H., Lin, J."Function of the macrophage‑capping protein in colorectal carcinoma". Oncology Letters 14.5 (2017): 5549-5555.
Chicago
Wu, W., Chen, J., Ding, Q., Yang, S., Wang, J., Yu, H., Lin, J."Function of the macrophage‑capping protein in colorectal carcinoma". Oncology Letters 14, no. 5 (2017): 5549-5555. https://doi.org/10.3892/ol.2017.6888
Copy and paste a formatted citation
x
Spandidos Publications style
Wu W, Chen J, Ding Q, Yang S, Wang J, Yu H and Lin J: Function of the macrophage‑capping protein in colorectal carcinoma. Oncol Lett 14: 5549-5555, 2017.
APA
Wu, W., Chen, J., Ding, Q., Yang, S., Wang, J., Yu, H., & Lin, J. (2017). Function of the macrophage‑capping protein in colorectal carcinoma. Oncology Letters, 14, 5549-5555. https://doi.org/10.3892/ol.2017.6888
MLA
Wu, W., Chen, J., Ding, Q., Yang, S., Wang, J., Yu, H., Lin, J."Function of the macrophage‑capping protein in colorectal carcinoma". Oncology Letters 14.5 (2017): 5549-5555.
Chicago
Wu, W., Chen, J., Ding, Q., Yang, S., Wang, J., Yu, H., Lin, J."Function of the macrophage‑capping protein in colorectal carcinoma". Oncology Letters 14, no. 5 (2017): 5549-5555. https://doi.org/10.3892/ol.2017.6888
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