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Article

Immunohistochemical profile and prognostic significance in primary central nervous system lymphoma: Analysis of 89 cases

  • Authors:
    • Jing Liu
    • Yaming Wang
    • Yuantao Liu
    • Zhe Liu
    • Qu Cui
    • Nan Ji
    • Shengjun Sun
    • Bingxu Wang
    • Yajie Wang
    • Xuefei Sun
    • Yuanbo Liu
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P.R. China, Department of Neurosurgery, Navy General Hospital, Beijing 100050, P.R. China, Department of Endocrinology, Qingdao Municipal Hospital Group, Qingdao, Shandong 266011, P.R. China, Duke University Hospital, Durham, NC 27710, USA, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P.R. China, Neuroimaging Center, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P.R. China, Department of Neurology, Central Hospital of Qilu Petrochemical Hospital Group, Zibo, Shandong 255400, P.R. China, Core Laboratory for Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P.R. China
  • Pages: 5505-5512
    |
    Published online on: September 6, 2017
       https://doi.org/10.3892/ol.2017.6893
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Abstract

The majority of primary central nervous system lymphomas (PCNSLs) are diffuse large B cell lymphoma, characterized by poor prognosis. In the present study, the expression of cluster of differentiation (CD)10, B cell lymphoma (BCL)‑6, multiple myeloma‑1 (MUM‑1), BCL‑2, CD138 and Ki‑67 was analyzed by immunohistochemistry in 89 Chinese PCNSL cases, and the potential prognostic significance was evaluated. CD10, BCL‑6, MUM‑1, BCL‑2 and CD138 were positive in 16.9 (15/89), 51.7 (46/89), 92.1 (82/89), 73.3 (63/86) and 0% (0/65) of all cases, respectively. According to the Hans algorithm, 71 patients (79.8%) were classified into the non‑germinal center B cell‑like (non‑GCB) group, indicating a post‑germinal center origin of PCNSL. The median follow‑up time of 73 patients was 13 months [95% confidence interval (CI), 10.93‑15.08]. The median overall survival (OS) time was 45.3 months (95% CI, 25.01‑65.59) and the median progression‑free survival (PFS) time was 30.0 months (95% CI, 13.43‑46.57). Age (>60 years) was associated with a shorter OS time (P=0.009). Ki‑67 (cutoff point 90%) was associated with shorter OS (P=0.037) and shorter PFS (P=0.039) times. No other immunohistochemical markers were associated with prognosis. On multivariate analysis, age (>60 years) was associated with shorter OS time (P=0.038), but immunophenotype and expression status of Ki‑67, CD10, BCL‑6 and BCL‑2 did not predict prognosis. In conclusion, high Ki‑67 expression may predict poor prognosis in PCNSL. The present study was limited by its sample size and short follow‑up time. This requires more evidence to further clinical study.
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Copy and paste a formatted citation
Spandidos Publications style
Liu J, Wang Y, Liu Y, Liu Z, Cui Q, Ji N, Sun S, Wang B, Wang Y, Sun X, Sun X, et al: Immunohistochemical profile and prognostic significance in primary central nervous system lymphoma: Analysis of 89 cases. Oncol Lett 14: 5505-5512, 2017.
APA
Liu, J., Wang, Y., Liu, Y., Liu, Z., Cui, Q., Ji, N. ... Liu, Y. (2017). Immunohistochemical profile and prognostic significance in primary central nervous system lymphoma: Analysis of 89 cases. Oncology Letters, 14, 5505-5512. https://doi.org/10.3892/ol.2017.6893
MLA
Liu, J., Wang, Y., Liu, Y., Liu, Z., Cui, Q., Ji, N., Sun, S., Wang, B., Wang, Y., Sun, X., Liu, Y."Immunohistochemical profile and prognostic significance in primary central nervous system lymphoma: Analysis of 89 cases". Oncology Letters 14.5 (2017): 5505-5512.
Chicago
Liu, J., Wang, Y., Liu, Y., Liu, Z., Cui, Q., Ji, N., Sun, S., Wang, B., Wang, Y., Sun, X., Liu, Y."Immunohistochemical profile and prognostic significance in primary central nervous system lymphoma: Analysis of 89 cases". Oncology Letters 14, no. 5 (2017): 5505-5512. https://doi.org/10.3892/ol.2017.6893
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Wang Y, Liu Y, Liu Z, Cui Q, Ji N, Sun S, Wang B, Wang Y, Sun X, Sun X, et al: Immunohistochemical profile and prognostic significance in primary central nervous system lymphoma: Analysis of 89 cases. Oncol Lett 14: 5505-5512, 2017.
APA
Liu, J., Wang, Y., Liu, Y., Liu, Z., Cui, Q., Ji, N. ... Liu, Y. (2017). Immunohistochemical profile and prognostic significance in primary central nervous system lymphoma: Analysis of 89 cases. Oncology Letters, 14, 5505-5512. https://doi.org/10.3892/ol.2017.6893
MLA
Liu, J., Wang, Y., Liu, Y., Liu, Z., Cui, Q., Ji, N., Sun, S., Wang, B., Wang, Y., Sun, X., Liu, Y."Immunohistochemical profile and prognostic significance in primary central nervous system lymphoma: Analysis of 89 cases". Oncology Letters 14.5 (2017): 5505-5512.
Chicago
Liu, J., Wang, Y., Liu, Y., Liu, Z., Cui, Q., Ji, N., Sun, S., Wang, B., Wang, Y., Sun, X., Liu, Y."Immunohistochemical profile and prognostic significance in primary central nervous system lymphoma: Analysis of 89 cases". Oncology Letters 14, no. 5 (2017): 5505-5512. https://doi.org/10.3892/ol.2017.6893
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