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Quantitative analysis of permeability for glioma grading using dynamic contrast‑enhanced magnetic resonance imaging

  • Authors:
    • Ming Zhao
    • Li‑Li Guo
    • Ning Huang
    • Qiong Wu
    • Li Zhou
    • Hui Zhao
    • Jing Zhang
    • Kuang Fu
  • View Affiliations / Copyright

    Affiliations: Department of MR Diagnosis, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China, Life Science, GE Healthcare Life Sciences China, Beijing 100176, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5418-5426
    |
    Published online on: September 6, 2017
       https://doi.org/10.3892/ol.2017.6895
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Abstract

The objective of the present study was to quantitatively analyze the permeability of tumor entity and peritumor edema in glioma grading, using dynamic contrast‑enhanced magnetic resonance imaging (DCE‑MRI). In the present retrospective study, 80 patients underwent T1‑weighted DCE‑MRI examination at 3.0 T and the pathological results (including astrocytoma and oligodendroglioma) were obtained between January 2012 and June 2015. All cases were surgically validated as grade I‑IV gliomas. The original DCE‑MRI data were analyzed using dual compartment modified Tofts model. The forward volume transfer constant (Ktrans), backflux rate (kep) and fractional volume (ve) were calculated with the region of interest selected on the highest permeability area of the tumor entity and peritumor edema. Analysis of variance with the Bonferroni correction was used to compare the values of Ktrans, kep, and ve of the tumor entity and peritumor edema in different glioma grades. The results of the present study revealed that the Ktrans, kep, and ve values in each stage were associated with the pathological grading (r=0.951, 0.804 and 0.766, respectively). There were significant differences identified between different tumor grades in Ktrans, kep, with the exception being between grades II and III in kep. In addition, there was a significant difference revealed between grade I/II and grade III/IV in ve. Receiver operator characteristics curve analysis was used to evaluate the diagnosis accuracies of permeability parameters. Ktrans was demonstrated to exhibit the highest sensitivity and specificity for evaluating the tumor grade. With the threshold values of 0.160, 0.420 and 0.935 in Ktrans on tumor, glioma grades I vs. II, II vs III and III vs. IV may be differentiated with sensitivities of 0.900, 0.950 and 0.950, and specificities of 0.950, 0.950 and 0.850, respectively. Furthermore, associations were observed between the Ktrans, kep and ve values of peritumor edema and the pathological grading in glioma (Ktrans r=0.438, P<0.001; Kep r=0.385, P<0.001; Ve r=0.397, P<0.001, respectively). Ktrans values in peritumoral edema revealed significant differences between low‑grade and high‑grade glioma. The sensitivity and specificity for Ktrans of peritumor edema were 0.975 and 0.950, with a threshold value of 0.007. Therefore, the DCE‑MRI parameters of Ktrans of tumor entity and peritumor edema in gliomas may be used to accurately differentiate glioma grades.
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1 

Ohgaki H: Epidemiology of brain tumors. Methods Mol Biol. 472:323–342. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW and Kleihues P: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 114:97–109. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Inoue T, Ogasawara K, Beppu T, Ogawa A and Kabasawa H: Diffusion tensor imaging for preoperative evaluation of tumor grade in gliomas. Clin Neurol Neurosurg. 107:174–180. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Zonari P, Baraldi P and Crisi G: Multimodal MRI in the characterization of glial neoplasms: The combined role of singl-evoxel MR spectroscopy, diffusion imaging and echo-planar perfusion imaging. Neuroradiology. 49:795–803. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Takekawa Y and Sawada T: Vascular endothelial growth factor and neovascularization in astrocytic tumors. Pathol Int. 48:109–114. 1998. View Article : Google Scholar : PubMed/NCBI

6 

Abdulrauf SI, Edvardsen K, Ho KL, Yang XY, Rock JP and Rosenblum ML: Vascular endothelial growth factor expression and vascular density as prognostic markers of survival in patients with low-grade astrocytoma. J Neurosur. 88:513–520. 1998. View Article : Google Scholar

7 

Brem S, Cotran R and Folkman J: Tumor angiogenesis: A quantitative method for histologic grading. J Natl Cancer Inst. 48:347–356. 1972.PubMed/NCBI

8 

Maeda M, Itoh S, Kimura H, Iwasaki T, Hayashi N, Yamamoto K, Ishii Y and Kubota T: Tumor vascularity in the brain: Evaluation with dynamic susceptibility-contrast MR imaging. Radiology. 189:233–238. 1993. View Article : Google Scholar : PubMed/NCBI

9 

Aronen HJ, Gazit IE, Louis DN, Buchbinder BR, Pardo FS, Weisskoff RM, Harsh GR, Cosgrove GR, Halpern EF, Hochberg FH, et al: Cerebral blood volume maps of gliomas: Comparison with tumor grade and histologic findings. Radiology. 191:41–51. 1994. View Article : Google Scholar : PubMed/NCBI

10 

Sugahara T, Korogi Y, Kochi M, Ikushima I, Hirai T, Okuda T, Shigematsu Y, Liang L, Ge Y, et al: Correlation of MR imaging-determined cerebral blood volume maps with histologic and angiographic determination of vascularity of gliomas. AJR Am J Roentgenol. 171:1479–1486. 1998. View Article : Google Scholar : PubMed/NCBI

11 

Knopp EA, Cha S, Johnson G, Mazumdar A, Golfinos JG, Zagzag D, Miller DC, Kelly PJ and Kricheff II: Glial neoplasms: Dynamic contrast-enhanced T2*-weighted MR imaging. Radiology. 211:791–798. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Tofts PS, Brix G, Buckley DL, Evelhoch JL, Henderson E, Knopp MV, Larsson HB, Lee TY, Mayr NA, Parker GJ, et al: Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: Standardized quantities and symbols. J Magn Reson Imaging. 10:223–232. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Zhang N, Zhang L, Qiu B, Meng L, Wang X and Hou BL: Correlation of volume transfer coefficient Ktrans with histopathologic grades of gliomas. J Magn Reson Imaging. 36:355–363. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Jia Z, Geng D, Xie T, Zhang J and Liu Y: Quantitative analysis of neovascular permeability in glioma by dynamic contrast-enhanced MR imaging. J Clin Neurosci. 19:820–823. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Dujardin MI, Sourbron SP, Chaskis C, Verellen D, Stadnik T, de Mey J and Luypaert R: Quantification of cerebral tumour blood flow and permeability with T1-weighted dynamic contrast enhanced MRI: A feasibility study. J Neuroradiol. 39:227–235. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Sourbron SP and Buckley DL: Tracer kinetic modelling in MRI: Estimating perfusion and capillary permeability. Phys Med Biol. 57:R1–33. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Johnson G, Wetzel SG, Cha S, Babb J and Tofts PS: Measuring blood volume and vascular transfer constant from dynamic, T(2)*-weighted contrast-enhanced MRI. Magn Reson Med. 51:961–968. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Rosen BR, Belliveau JW, Vevea JM and Brady TJ: Perfusion imaging with NMR contrast agents. Magn Reson Med. 14:249–265. 1990. View Article : Google Scholar : PubMed/NCBI

19 

Murase K: Efficient method for calculating kinetic parameters using T1-weighted dynamic contrast-enhanced magnetic resonance imaging. Magn Reson Med. 51:858–862. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Roberts HC, Roberts TP, Brasch RC and Dillon WP: Quantitative measurement of microvascular permeability in human brain tumors achieved using dynamic contrast-enhanced MR imaging: Correlation with histologic grade. AJNR Am J Neuroradiol. 21:891–899. 2000.PubMed/NCBI

21 

Daldrup H, Shames DM, Wendland M, Okuhata Y, Link TM, Rosenau W, Lu Y and Brasch RC: Correlation of dynamic contrast-enhanced MR imaging with histologic tumor grade: Comparison of macromolecular and small-molecular contrast media. AJR Am J Roentgenol. 171:941–949. 1998. View Article : Google Scholar : PubMed/NCBI

22 

Provenzale JM, Wang GR, Brenner T, Petrella JR and Sorensen AG: Comparison of permeability in high-grade and low-grade brain tumors using dynamic susceptibility contrast MR imaging. AJR Am J Roentgenol. 178:711–716. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Roberts HC, Roberts TP, Ley S, Dillon WP and Brasch RC: Quantitative estimation of microvascular permeability in human brain tumors: Correlation of dynamic Gd-DTPA-enhanced MR imaging with histopathologic grading. Acad Radiol. 9 (Suppl 1):S151–S155. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Falk A, Fahlström M, Rostrup E, Berntsson S, Zetterling M, Morell A, Larsson HB, Smits A and Larsson EM: Discrimination between glioma grades II and III in suspected low-grade gliomas using dynamic contrast-enhanced and dynamic susceptibility contrast perfusion MR imaging: A histogram analysis approach. Neuroradiology. 56:1031–1038. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Roy B, Awasthi R, Bindal A, Sahoo P, Kumar R, Behari S, Ojha BK, Husain N, Pandey CM, Rathore RK and Gupta RK: Comparative evaluation of 3-dimensional pseudocontinuous arterial spin labeling with dynamic contrast-enhanced perfusion magnetic resonance imaging in grading of human glioma. J Comput Assist Tomogr. 37:321–326. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Choi HS, Kim AH, Ahn SS, Shin NY, Kim J and Lee SK: Glioma grading capability: Comparisons among parameters from dynamic contrast-enhanced MRI and ADC value on DWI. Korean J Radiol. 14:487–492. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Jung SC, Yeom JA, Kim JH, Ryoo I, Kim SC, Shin H, Lee AL, Yun TJ, Park CK, Sohn CH, et al: Glioma: Application of histogram analysis of pharmacokinetic parameters from T1-weighted dynamic contrast-enhanced MR imaging to tumor grading. AJNR Am J Neuroradiol. 35:1103–1110. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Filice S and Crisi G: Dynamic contrast-enhanced perfusion MRI of high grade brain gliomas obtained with arterial or venous waveform input function. J Neuroimaging. 26:124–129. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Bruger PC, Vogel FS, Green SB and Strike TA: Glioblastoma multiforme and anaplastie astrocytoma: Pathologic criteria and prognostic implications. Cancer. 565:1106–1111. 1985. View Article : Google Scholar

30 

Winkler F, Kienast Y, Fuhrmann M, Von Baumgarten L, Burgold S, Mitteregger G, Kretzschmar H and Herms J: Imaging glioma cell invasion in vivo reveals mechanisms of dissemination and peritumoral angiogenesis. Glia. 57:1306–1315. 2009. View Article : Google Scholar : PubMed/NCBI

31 

van Dijke CF, Brasch RC, Roberts TP, Weidner N, Mathur A, Shames DM, Mann JS, Demsar F, Lang P and Schwickert HC: Mammary carcinoma model: Correlation of macromolecular contrast-enhanced MR imaging characterizations of tumor microvasculature and histologic capillary density. Radiology. 198:813–818. 1996. View Article : Google Scholar : PubMed/NCBI

32 

Schwickert HC, Stiskal M, Roberts TP, van Dijke CF, Mann J, Mühler A, Shames DM, Demsar F, Disston A and Brasch RC: Contrast-enhanced MR imaging assessment of tumor capillary permeability: Effect of irradiation on delivery of chemotherapy. Radiology. 198:893–898. 1996. View Article : Google Scholar : PubMed/NCBI

33 

Taylor JS, Tofts PS, Port R, Evelhoch JL, Knopp M, Reddick WE, Runge VM and Mayr N: MR imaging of tumor microcirculation: Promise for the new millennium. J Magn Reson Imaging. 10:903–907. 1999. View Article : Google Scholar : PubMed/NCBI

34 

Jensen RL, Mumert ML, Gillespie DL, Kinney AY, Schabel MC and Salzman KL: Preoperative dynamic contrast-enhanced MRI correlates with molecular markers of hypoxia and vascularity in specific areas of intratumoral microenvironment and is predictive of patient outcome. Neuro Oncol. 16:280–291. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao M, Guo LL, Huang N, Wu Q, Zhou L, Zhao H, Zhang J and Fu K: Quantitative analysis of permeability for glioma grading using dynamic contrast‑enhanced magnetic resonance imaging. Oncol Lett 14: 5418-5426, 2017.
APA
Zhao, M., Guo, L., Huang, N., Wu, Q., Zhou, L., Zhao, H. ... Fu, K. (2017). Quantitative analysis of permeability for glioma grading using dynamic contrast‑enhanced magnetic resonance imaging. Oncology Letters, 14, 5418-5426. https://doi.org/10.3892/ol.2017.6895
MLA
Zhao, M., Guo, L., Huang, N., Wu, Q., Zhou, L., Zhao, H., Zhang, J., Fu, K."Quantitative analysis of permeability for glioma grading using dynamic contrast‑enhanced magnetic resonance imaging". Oncology Letters 14.5 (2017): 5418-5426.
Chicago
Zhao, M., Guo, L., Huang, N., Wu, Q., Zhou, L., Zhao, H., Zhang, J., Fu, K."Quantitative analysis of permeability for glioma grading using dynamic contrast‑enhanced magnetic resonance imaging". Oncology Letters 14, no. 5 (2017): 5418-5426. https://doi.org/10.3892/ol.2017.6895
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao M, Guo LL, Huang N, Wu Q, Zhou L, Zhao H, Zhang J and Fu K: Quantitative analysis of permeability for glioma grading using dynamic contrast‑enhanced magnetic resonance imaging. Oncol Lett 14: 5418-5426, 2017.
APA
Zhao, M., Guo, L., Huang, N., Wu, Q., Zhou, L., Zhao, H. ... Fu, K. (2017). Quantitative analysis of permeability for glioma grading using dynamic contrast‑enhanced magnetic resonance imaging. Oncology Letters, 14, 5418-5426. https://doi.org/10.3892/ol.2017.6895
MLA
Zhao, M., Guo, L., Huang, N., Wu, Q., Zhou, L., Zhao, H., Zhang, J., Fu, K."Quantitative analysis of permeability for glioma grading using dynamic contrast‑enhanced magnetic resonance imaging". Oncology Letters 14.5 (2017): 5418-5426.
Chicago
Zhao, M., Guo, L., Huang, N., Wu, Q., Zhou, L., Zhao, H., Zhang, J., Fu, K."Quantitative analysis of permeability for glioma grading using dynamic contrast‑enhanced magnetic resonance imaging". Oncology Letters 14, no. 5 (2017): 5418-5426. https://doi.org/10.3892/ol.2017.6895
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