Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

POEMS syndrome presentation with progressive weakness in upper and lower limbs: A case report

  • Authors:
    • Chuang‑Jie Cao
    • Cheng‑Yun Dou
    • Ke‑Hua Zhou
    • Jin‑Bo Liu
    • Hong Lai
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Affiliated Hospital of Sun Yat‑san University, Guangzhou, Guangdong 510080, P.R. China, Department of Hepatology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China, Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China
    Copyright: © Cao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5197-5202
    |
    Published online on: September 6, 2017
       https://doi.org/10.3892/ol.2017.6904
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Polyneuropathy, organomegaly, endocrinopathy, M proteins, and skin changes (POEMS) syndrome is a rare variant of plasma cell disorders with multiple systemic manifestations. A 50‑year‑old female patient presented with progressive weakness in her upper and lower limbs; tingling, numbness and burning in her feet; polyneuropathy (demyelinating in the majority of cases of POEMS syndrome); monoclonal plasma cell disorder (typicallyλ‑restricted in cases of POEMS syndrome); sclerotic lesions on the spine and pelvis; organomegaly, including hepatomegaly, splenomegaly and lymphadenopathy; edema; pleural effusion; adrenal, thyroidal, pituitary, gonadal and pancreatic endocrinopathy; skin changes, including hyperpigmentation, dry skin and hypertrichosis; thrombocytosis; pulmonary hypertension; low vitamin B12 and weight loss. Following the diagnosis of POEMS syndrome, the patient was treated only with pain‑alleviating corticosteroids. Respiratory failure‑induced mortality occurred 24 months after the patient first experienced difficulty walking and numbness in her lower extremities. The present study suggests that abnormal symptoms in cases of POEMS syndrome should be further evaluated during the diagnosis and treatment.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Dispenzieri A, Kyle RA, Lacy MQ, Rajkumar SV, Therneau TM, Larson DR, Greipp PR, Witzig TE, Basu R, Suarez GA, et al: POEMS syndrome: Definitions and long-term outcome. Blood. 101:2496–2506. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Dispenzier A: POEMS syndrome: 2011 update on diagnosis, risk-stratification and management. Am J Hematol. 86:592–601. 2011.

3 

Sanada S, Ookawara S, Karube H, Shindo T, Goto T, Nakamichi T, Saito M, Matsubara M and Suzuki M: Marked recovery of severe renal lesions in POEMS syndrome with high-dose melphalan therapy supported by autologous blood stem cell transplantation. Am J Kidney Dis. 47:672–679. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Nakamoto Y, Imai H, Yasuda T, Wakui H and Miura AB: A spectrum of clinicopathological features of nephropathy associated with POEMS syndrome. Nephrol Dial Transplant. 14:2370–2378. 1999. View Article : Google Scholar : PubMed/NCBI

5 

Watanabe O, Arimura K, Kitajima I, Osame M and Maruyama I: Greatly raised vascular endothelial growth factor (VEGF) in POEMS syndrome. Lancet. 347:7021996. View Article : Google Scholar : PubMed/NCBI

6 

Singh D, Wadhwa J, Kumar L, Raina V, Agarwal A and Kochupillai V: POEMS syndrome: Experience with fourteen cases. Leuk Lymphoma. 44:1749–1752. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Soubrier MJ, Dubost JJ and Sauvezie BJ: POEMS syndrome: A study of 25 cases and a review of the literature. French Study Group on POEMS syndrome. Am J Med. 97:543–553. 1994. View Article : Google Scholar : PubMed/NCBI

8 

Li J, Zhou DB, Huang Z, Jiao L, Duan MH, Zhang W, Zhao YQ and Shen T: Clinical characteristics and long-term outcome of patients with POEMS syndrome in China. Ann Hematol. 90:819–826. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Kulkarni GB, Mahadevan A, Taly AB, Yasha TC, Seshagiri KS, Nalini A, Satishchandra P, Veerendrakumar M and Shankar SK: Clinicopathological profile of polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes (POEMS) syndrome. J Clin Neurosci. 18:356–360. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Plata Bello J and Garcia-Marin V: POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, multiple myeloma and skin changes) with cranial vault plasmocytoma and the role of surgery in its management: A case report. J Med Case Rep. 7:2452013. View Article : Google Scholar : PubMed/NCBI

11 

Lee FY and Chiu HC: POEMS syndrome with calciphylaxis: A case report. Acta Derm Venereol. 91:96–97. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Dispenzieri A: POEMS syndrome: 2014 update on diagnosis, risk-stratification, and management. Am J Hematol. 89:214–223. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Nakamura Y, Nishimura M, Terano T, McNamara KM, Sasano H, Kurosu A and Joh K: A patient with POEMS syndrome: The pathology of glomerular microangiopathy. Tohoku J Exp Med. 231:229–234. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Kaya P, Alemdaroğlu I, Yilmaz Ö, Karaduman A and Topaloğlu H: Effect of muscle weakness distribution on balance in neuromuscular disease. Pediatr Int. 57:92–97. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Devine MS, Kiernan MC, Heggie S, McCombe PA and Henderson RD: Study of motor asymmetry in ALS indicates an effect of limb dominance on onset and spread of weakness and an important role for upper motor neurons. Amyotroph Lateral Scler Frontotemporal Degener. 15:481–487. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Kuo DC, Bilal S and Koller P: Asymmetric weakness and west nile virus infection. J Emerg Med. 49:274–276. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Iolascon G, de Sire A, Calafiore D, Moretti A, Gimigliano R and Gimigliano F: Hypovitaminosis D is associated with a reduction in upper and lower limb muscle strength and physical performance in post-menopausal women: A retrospective study. Aging Clin Exp Res. 27 Suppl 1:S23–S30. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Dispenzieri A: POEMS Syndrome: 2014 update on diagnosis, risk-stratification and management. Am J Hematol. 89:213–223. 2014. View Article : Google Scholar

19 

Bardwick NJ, Zvaifler GN, Gill GN, Newman D, Greenway G and Resnick DL: Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes: The POEMS syndrome. Report on two cases and a review of the literature. Medicine (Baltimore). 59:311–322. 1980. View Article : Google Scholar : PubMed/NCBI

20 

Rose C, Zandecki M, Copin MC, Gosset P, Labalette M, Hatron PY, Jauberteau MO, Devulder B, Bauters F and Facon T: POEMS syndrome: Report on six patients with unusual clinical signs, elevated levels of cytokines, macrophage involvement and chromosomal aberrations of bone marrow plasma cells. Leukemia. 11:1318–1323. 1997. View Article : Google Scholar : PubMed/NCBI

21 

Hitoshi S, Suzuki K and Sakuta M: Elevated serum interleukin-6 in POEMS syndrome reflects the activity of the disease. Intern Med. 33:583–587. 1994. View Article : Google Scholar : PubMed/NCBI

22 

Soubrier M, Sauron C, Souweine B, Larroche C, Wechsler B, Guillevin L, Piette JC, Rousset H and Deteix P: Growth factors and proinflammatory cytokines in the renal involvement of POEMS syndrome. Am J Kidney Dis. 34:633–638. 1999. View Article : Google Scholar : PubMed/NCBI

23 

Tokashiki T, Hashiguchi T, Arimura K, Eiraku N, Maruyama I and Osame M: Predictive value of serial platelet count and VEGF determination for the management of DIC in the Crow-Fukase (POEMS) syndrome. Intern Med. 42:1240–1243. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Niimi H, Arimura K, Jonosono M, Hashiguchi T, Kawabata M, Osame M and Kitajima I: VEGF is causative for pulmonary hypertension in a patient with Crow-Fukase (POEMS) syndrome. Intern Med. 39:1101–1104. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Dispenzieri A: How I treat POEMS syndrome. Blood. 119:5650–5658. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Kawano Y, Nakama T, Hata H, Kimura E, Maruyoshi N, Uchino M and Mitsuya H: Successful treatment with rituximab and thalidomide of POEMS syndrome associated with Waldenstrom macroglobulinemia. J Neurol Sci. 297:101–104. 2012. View Article : Google Scholar

27 

Ohwada C, Nakaseko C, Sakai S, Takeda Y, Abe D, Takeuchi M, Sakaida E, Masuda S, Shimizu N, Cho R, et al: Successful combination treatment with bevacizumab, thalidomide and autologous PBSC for severe POEMS syndrome. Bone Marrow Transplant. 43:739–740. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Kotani Y, Ito M, Abumi K, Yasui K and Minami A: Neurological recovery from pentaplegia after resection for sacral plasmacytoma presenting with POEMS syndrome. J Neurosurg Spine. 10:324–328. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Allam JS, Kennedy CC, Aksamit TR and Dispenzieri A: Pulmonary manifestations in patients with POEMS syndrome: A retrospective review of 137 patients. Chest. 133:969–974. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Cao CJ, Dou CY, Zhou KH, Liu JB and Lai H: POEMS syndrome presentation with progressive weakness in upper and lower limbs: A case report . Oncol Lett 14: 5197-5202, 2017.
APA
Cao, C., Dou, C., Zhou, K., Liu, J., & Lai, H. (2017). POEMS syndrome presentation with progressive weakness in upper and lower limbs: A case report . Oncology Letters, 14, 5197-5202. https://doi.org/10.3892/ol.2017.6904
MLA
Cao, C., Dou, C., Zhou, K., Liu, J., Lai, H."POEMS syndrome presentation with progressive weakness in upper and lower limbs: A case report ". Oncology Letters 14.5 (2017): 5197-5202.
Chicago
Cao, C., Dou, C., Zhou, K., Liu, J., Lai, H."POEMS syndrome presentation with progressive weakness in upper and lower limbs: A case report ". Oncology Letters 14, no. 5 (2017): 5197-5202. https://doi.org/10.3892/ol.2017.6904
Copy and paste a formatted citation
x
Spandidos Publications style
Cao CJ, Dou CY, Zhou KH, Liu JB and Lai H: POEMS syndrome presentation with progressive weakness in upper and lower limbs: A case report . Oncol Lett 14: 5197-5202, 2017.
APA
Cao, C., Dou, C., Zhou, K., Liu, J., & Lai, H. (2017). POEMS syndrome presentation with progressive weakness in upper and lower limbs: A case report . Oncology Letters, 14, 5197-5202. https://doi.org/10.3892/ol.2017.6904
MLA
Cao, C., Dou, C., Zhou, K., Liu, J., Lai, H."POEMS syndrome presentation with progressive weakness in upper and lower limbs: A case report ". Oncology Letters 14.5 (2017): 5197-5202.
Chicago
Cao, C., Dou, C., Zhou, K., Liu, J., Lai, H."POEMS syndrome presentation with progressive weakness in upper and lower limbs: A case report ". Oncology Letters 14, no. 5 (2017): 5197-5202. https://doi.org/10.3892/ol.2017.6904
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team