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Correlation between the presence of circulating tumor cells and the pathologic type and staging of non-small cell lung cancer during the early postoperative period

  • Authors:
    • Zhanqiang Xie
    • Xiaotian Gao
    • Keluo Cheng
    • Lishuang Yu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiothoracic Surgery, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China, Department of Gastroenterology, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China
    Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5825-5830
    |
    Published online on: September 7, 2017
       https://doi.org/10.3892/ol.2017.6910
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Abstract

This study investigated possible correlations between the presence of circulating tumor cells (CTCs) and the pathologic types and staging of non-small cell lung cancer (NSCLC) during the early postoperative period. Sixty-nine patients with NSCLC were enrolled in the study. Clinical staging was performed by postoperative pathological examination and imaging. Multiple mRNA in situ analyses targeting specifically expressed genes were carried out to identify the presence of CTCs. Correlations between age, sex, TNM stage and pathological types with the detection rate of CTCs were also established. The results showed the positivity rate of CTCs in patients >55 years was significantly higher than that of patients <55 years (94.74 vs. 70.97%, P<0.05). There was no significant difference in the positivity rate of CTCs between male and female patients (85.71 vs. 85.29%, P>0.05). The correlations between the detection rate of epithelial type or mixed type CTCs with tumor size, lymph node metastasis and distant metastasis TNM in patients with NSCLC were not significant (P>0.05). However, higher TNM stages correlated with higher detection rates of mesenchymal CTCs (P<0.05). There were also significant differences in the detection rates of CTCs amongst the three different pathologic types (adenocarcinoma, squamous cell and large cell carcinomas) (P<0.05). Based on our results, the detection of mesenchymal CTCs during the early postoperative period can help prognosticate the recurrence and metastasis of NSCLC, which is beneficial to the development of individualized treatment strategies.
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1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Woodard GA, Jones KD and Jablons DM: Lung cancer staging and prognosis. Cancer Treat Res. 170:47–75. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Jeon JH, Kang CH, Kim HS, Seong YW, Park IK, Kim YT and Kim JH: Video-assisted thoracoscopic lobectomy in non-small-cell lung cancer patients with chronic obstructive pulmonary disease is associated with lower pulmonary complications than open lobectomy: A propensity score-matched analysis. Eur J Cardiothorac Surg. 45:640–645. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Huang D, Fang F and Xu F: Hyperoxia induces inflammation and regulates cytokine production in alveolar epithelium through TLR2/4-NF-κB-dependent mechanism. Eur Rev Med Pharmacol Sci. 20:1399–1410. 2016.PubMed/NCBI

5 

Zuo X, Zhang J, Zhang Y, Hsu SC, Zhou D and Guo W: Exo70 interacts with the Arp2/3 complex and regulates cell migration. Nat Cell Biol. 8:1383–1388. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Saygideğer-Kont Y, Minas TZ, Jones H, Hour S, Çelik H, Temel I, Han J, Atabey N, Erkizan HV, Toretsky JA, et al: Ezrin enhances EGFR signaling and modulates erlotinib sensitivity in non-small cell lung cancer cells. Neoplasia. 18:111–120. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Hong Y, Li Z and Zhang Q: A circulating tumor cell cluster-based model for tumor metastasis (Hypothesis). Oncol Lett. 12:4891–4895. 2016.PubMed/NCBI

8 

Ilie M, Hofman V, Long E, Bordone O, Selva E, Washetine K, Marquette CH and Hofman P: Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine? Ann Transl Med. 2:1072014.PubMed/NCBI

9 

Reeh M, Effenberger KE, Koenig AM, Riethdorf S, Eichstädt D, Vettorazzi E, Uzunoglu FG, Vashist YK, Izbicki JR, Pantel K, et al: Circulating tumor cells as a biomarker for preoperative prognostic staging in patients with EC. Ann Surg. 261:1124–1130. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Fusi A, Metcalf R, Krebs M, Dive C and Blackhall F: Clinical utility of circulating tumour cell detection in non-small-cell lung cancer. Curr Treat Options Oncol. 14:610–622. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Li H, Song P, Zou B, Liu M, Cui K, Zhou P, Li S and Zhang B: Circulating tumor cell analyses in patients with esophageal squamous cell carcinoma using epithelial Marker-Dependent and-Independent approaches. Medicine (Baltimore). 94:e15652015. View Article : Google Scholar : PubMed/NCBI

12 

Zhang Z, Xiao Y, Zhao J, Chen M, Xu Y, Zhong W, Xing J and Wang M: Relationship between circulating tumour cell count and prognosis following chemotherapy in patients with advanced non-small-cell lung cancer. Respirology. 21:519–525. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Lagerwaard FJ, Aaronson NK, Gundy CM, Haasbeek CJ, Slotman BJ and Senan S: Patient-reported quality of life after stereotactic ablative radiotherapy for early-stage lung cancer. J Thorac Oncol. 7:1148–1154. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Donato BM, Burns L, Willey V, Cohenuram M, Oliveria S and Yood MU: Treatment patterns in patients with advanced breast cancer who were exposed to an anthracycline, a taxane and capecitabine: A descriptive report. Clin Ther. 32:546–554. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Khan MS, Kirkwood A, Tsigani T, Garcia-Hernandez J, Hartley JA, Caplin ME and Meyer T: Circulating tumor cells as prognostic markers in neuroendocrine tumors. J Clin Oncol. 31:365–372. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Stovold R, Blackhall F, Meredith S, Hou J, Dive C and White A: Biomarkers for small cell lung cancer: Neuroendocrine, epithelial and circulating tumour cells. Lung Cancer. 76:263–268. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Reijm EA, Sieuwerts AM, Smid M, Vries JB, Mostert B, Onstenk W, Peeters D, Dirix LY, Seynaeve CM, Jager A, et al: An 8-gene mRNA expression profile in circulating tumor cells predicts response to aromatase inhibitors in metastatic breast cancer patients. BMC Cancer. 16:1232016. View Article : Google Scholar : PubMed/NCBI

18 

Yu M, Bardia A, Wittner BS, Stott SL, Smas ME, Ting DT, Isakoff SJ, Ciciliano JC, Wells MN, Shah AM, et al: Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science. 339:580–584. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Lecharpentier A, Vielh P, Perez-Moreno P, Planchard D, Soria JC and Farace F: Detection of circulating tumour cells with a hybrid (epithelial/mesenchymal) phenotype in patients with metastatic non-small cell lung cancer. Br J Cancer. 105:1338–1341. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Hosokawa M, Yoshikawa T, Negishi R, Yoshino T, Koh Y, Kenmotsu H, Naito T, Takahashi T, Yamamoto N, Kikuhara Y, et al: Microcavity array system for size-based enrichment of circulating tumor cells from the blood of patients with small-cell lung cancer. Anal Chem. 85:5692–5698. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Catenacci DV, Chapman CG, Xu P, Koons A, Konda VJ, Siddiqui UD and Waxman I: Acquisition of portal venous circulating tumor cells from patients with pancreaticobiliary cancers by endoscopic ultrasound. Gastroenterology. 149:1794–1803.e4. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Zhang Z, Shiratsuchi H, Palanisamy N, Nagrath S and Ramnath N: Expanded circulating tumor cells from a patient with ALK-positive lung cancer present with EML4-ALK rearrangement along with resistance mutation and enable drug sensitivity testing: A Case Study. J Thorac Oncol. 12:397–402. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Hyun KA, Kwon K, Han H, Kim SI and Jung HI: Microfluidic flow fractionation device for label-free isolation of circulating tumor cells (CTCs) from breast cancer patients. Biosens Bioelectron. 40:206–212. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Bystricky B, Jurisova S, Karaba M, Minarik G, Benca J, Sedlácková T, Tothova L, Vlkova B, Cierna Z, Janega P, et al: Relationship between circulating tumor cells and tissue plasminogen activator in patients with early breast cancer. Anticancer Res. 37:1787–1791. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Aieta M, Facchinetti A, De Faveri S, Manicone M, Tartarone A, Possidente L, Lerose R, Mambella G, Calderone G, Zamarchi R, et al: Monitoring and characterization of circulating tumor cells (CTCs) in a patient with EML4-ALK-positive non-small cell lung cancer (NSCLC). Clin Lung Cancer. 17:e173–e177. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Tsai WS, Chen JS, Shao HJ, Wu JC, Lai JM, Lu SH, Hung TF, Chiu YC, You JF, Hsieh PS, et al: Circulating tumor cell count correlates with colorectal neoplasm progression and is a prognostic marker for distant metastasis in non-metastatic patients. Sci Rep. 6:245172016. View Article : Google Scholar : PubMed/NCBI

27 

Chen X, Wang X, He H, Liu Z, Hu JF and Li W: Combination of circulating tumor cells with serum carcinoembryonic antigen enhances clinical prediction of non-small cell lung cancer. PLoS One. 10:e01262762015. View Article : Google Scholar : PubMed/NCBI

28 

Swanson SJ, Miller DL, McKenna RJ Jr, Howington J, Marshall MB, Yoo AC, Moore M, Gunnarsson CL and Meyers BF: Comparing robot-assisted thoracic surgical lobectomy with conventional video-assisted thoracic surgical lobectomy and wedge resection: Results from a multihospital database (Premier). J Thorac Cardiovasc Surg. 147:929–937. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Ross K, Pailler E, Faugeroux V, Taylor M, Oulhen M, Auger N, Planchard D, Soria JC, Lindsay CR, Besse B, et al: The potential diagnostic power of circulating tumor cell analysis for non-small-cell lung cancer. Expert Rev Mol Diagn. 15:1605–1629. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Mego M, Giordano A, De Giorgi U, Masuda H, Hsu L, Giuliano M, Fouad TM, Dawood S, Ueno NT, Valero V, et al: Circulating tumor cells in newly diagnosed inflammatory breast cancer. Breast Cancer Res. 17:22015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xie Z, Gao X, Cheng K and Yu L: Correlation between the presence of circulating tumor cells and the pathologic type and staging of non-small cell lung cancer during the early postoperative period. Oncol Lett 14: 5825-5830, 2017.
APA
Xie, Z., Gao, X., Cheng, K., & Yu, L. (2017). Correlation between the presence of circulating tumor cells and the pathologic type and staging of non-small cell lung cancer during the early postoperative period. Oncology Letters, 14, 5825-5830. https://doi.org/10.3892/ol.2017.6910
MLA
Xie, Z., Gao, X., Cheng, K., Yu, L."Correlation between the presence of circulating tumor cells and the pathologic type and staging of non-small cell lung cancer during the early postoperative period". Oncology Letters 14.5 (2017): 5825-5830.
Chicago
Xie, Z., Gao, X., Cheng, K., Yu, L."Correlation between the presence of circulating tumor cells and the pathologic type and staging of non-small cell lung cancer during the early postoperative period". Oncology Letters 14, no. 5 (2017): 5825-5830. https://doi.org/10.3892/ol.2017.6910
Copy and paste a formatted citation
x
Spandidos Publications style
Xie Z, Gao X, Cheng K and Yu L: Correlation between the presence of circulating tumor cells and the pathologic type and staging of non-small cell lung cancer during the early postoperative period. Oncol Lett 14: 5825-5830, 2017.
APA
Xie, Z., Gao, X., Cheng, K., & Yu, L. (2017). Correlation between the presence of circulating tumor cells and the pathologic type and staging of non-small cell lung cancer during the early postoperative period. Oncology Letters, 14, 5825-5830. https://doi.org/10.3892/ol.2017.6910
MLA
Xie, Z., Gao, X., Cheng, K., Yu, L."Correlation between the presence of circulating tumor cells and the pathologic type and staging of non-small cell lung cancer during the early postoperative period". Oncology Letters 14.5 (2017): 5825-5830.
Chicago
Xie, Z., Gao, X., Cheng, K., Yu, L."Correlation between the presence of circulating tumor cells and the pathologic type and staging of non-small cell lung cancer during the early postoperative period". Oncology Letters 14, no. 5 (2017): 5825-5830. https://doi.org/10.3892/ol.2017.6910
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