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Review Open Access

Immune‑related adverse events during anticancer immunotherapy: Pathogenesis and management (Review)

  • Authors:
    • Stefania Stucci
    • Raffaele Palmirotta
    • Anna Passarelli
    • Erica Silvestris
    • Antonella Argentiero
    • Laura Lanotte
    • Silvana Acquafredda
    • Annalisa Todisco
    • Franco Silvestris
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine and Clinical Oncology, University of Bari Aldo Moro, I‑70124 Bari, Italy
    Copyright: © Stucci et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5671-5680
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    Published online on: September 8, 2017
       https://doi.org/10.3892/ol.2017.6919
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Abstract

Immunotherapy is one of the most recent systemic treatments to emerge for use in oncology, and is based on the blocking of inhibitory immune checkpoints to potentiate the immune response to cancer. The anti‑cytotoxic T lymphocyte‑associated antigen‑4 antibody ipilimumab and anti‑programmed cell death protein 1 antibodies, including nivolumab and pembrolizumab, are currently available and widely used, and other immune‑inhibiting antibodies are now under intensive investigation. These antibodies have shown efficacy in a growing number of tumor types, following initial observations of their notable effects in melanoma treatment. Despite the efficacy of these antibodies, their novel mechanisms of action are also associated with a new class of side effects called immune‑related adverse events (IRAEs). These side effects do not share a common pathophysiology with other anticancer treatments and, therefore, they often require specific therapies. When detected early and correctly treated, IRAEs are reversible; however, they can become severe and life‑threatening if underestimated or inappropriately treated. This review aims to revisit the pathogenesis of IRAEs, with attention to gastrointestinal manifestations, since these are common and potentially dangerous complications of immunotherapy and represent a major cause of treatment discontinuation. Recommendations and guidelines for the management of IRAEs are also presented, in order to provide a clear and applicable algorithm for use by clinicians.
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1 

Yang Y: Cancer immunotherapy: Harnessing the immune system to battle cancer. J Clin Invest. 125:3335–3337. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Vinay DS, Ryan EP, Pawelec G, Talib WH, Stagg J, Elkord E, Lichtor T, Decker WK, Whelan RL, Kumara HM, et al: Immune evasion in cancer: Mechanistic basis and therapeutic strategies. Semin Cancer Biol. 35 Suppl:S185–S198. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Gajewski TF, Schreiber H and Fu YX: Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol. 14:1014–1022. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Pardoll DM: The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 12:252–264. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Callahan MK, Postow MA and Wolchok JD: CTLA-4 and PD-1 pathway blockade: Combinations in the clinic. Front Oncol. 4:3852015. View Article : Google Scholar : PubMed/NCBI

6 

Tucci M, Stucci S, Passarelli A, Giudice G, Dammacco F and Silvestris F: The immune escape in melanoma: Role of the impaired dendritic cell function. Expert Rev Clin Immunol. 10:1395–1404. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, Gonzalez R, Robert C, Schadendorf D, Hassel JC, et al: Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 363:711–723. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Swaika A, Hammond WA and Joseph RW: Current state of anti-PD-L1 and anti-PD-1 agents in cancer therapy. Mol Immunol. 67:4–17. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Wolchok JD, Kluger H, Callahan MK, Postow MA, Rizvi NA, Lesokhin AM, Segal NH, Ariyan CE, Gordon RA, Reed K, et al: Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med. 369:122–133. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Tarhini A: Immune-mediated adverse events associated with ipilimumab ctla-4 blockade therapy: The underlying mechanisms and clinical management. Scientifica (Cairo). 2013:8575192013.PubMed/NCBI

11 

Michot JM, Bigenwald C, Champiat S, Collins M, Carbonnel F, Postel-Vinay S, Berdelou A, Varga A, Bahleda R, Hollebecque A, et al: Immune-related adverse events with immune checkpoint blockade: A comprehensive review. Eur J Cancer. 54:139–148. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Larkin J, Chiarion-Sileni V, Gonzalez R, Grob JJ, Cowey CL, Lao CD, Schadendorf D, Dummer R, Smylie M, Rutkowski P, et al: Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med. 373:23–34. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Hodi FS, Chesney J, Pavlick AC, Robert C, Grossmann KF, McDermott DF, Linette GP, Meyer N, Giguere JK, Agarwala SS, et al: Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial. Lancet Oncol. 17:1558–1568. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, Powderly JD, Carvajal RD, Sosman JA, Atkins MB, et al: Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 366:2443–2454. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Devaud C, John LB, Westwood JA, Darcy PK and Kershaw MH: Immune modulation of the tumor microenvironment for enhancing cancer immunotherapy. Oncoimmunology. 2:e259612013. View Article : Google Scholar : PubMed/NCBI

16 

Topalian SL, Sznol M, McDermott DF, Kluger HM, Carvajal RD, Sharfman WH, Brahmer JR, Lawrence DP, Atkins MB, Powderly JD, et al: Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J Clin Oncol. 32:1020–1030. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Weber JS, Dummer R, de Pril V, Lebbé C and Hodi FS: MDX010-20 Investigators: Patterns of onset and resolution of immune-related adverse events of special interest with ipilimumab: Detailed safety analysis from a phase 3 trial in patients with advanced melanoma. Cancer. 119:1675–1682. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Wolchok JD, Neyns B, Linette G, Negrier S, Lutzky J, Thomas L, Waterfield W, Schadendorf D, Smylie M, Guthrie T Jr, et al: Ipilimumab monotherapy in patients with pretreated advanced melanoma: A randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol. 11:155–164. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Abdel-Rahman O, ElHalawani H and Fouad M: Risk of gastrointestinal complications in cancer patients treated with immune checkpoint inhibitors: A meta-analysis. Immunotherapy. 7:1213–1227. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Postow MA, Callahan MK and Wolchok JD: Immune checkpoint blockade in cancer therapy. J Clin Oncol. 33:1974–1982. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Robert C, Schachter J, Long GV, Arance A, Grob JJ, Mortier L, Daud A, Carlino MS, McNeil C, Lotem M, et al: Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med. 372:2521–2532. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Bertrand A, Kostine M, Barnetche T, Truchetet ME and Schaeverbeke T: Immune related adverse events associated with anti-CTLA-4 antibodies: Systematic review and meta-analysis. BMC Med. 13:2112015. View Article : Google Scholar : PubMed/NCBI

23 

Beck KE, Blansfield JA, Tran KQ, Feldman AL, Hughes MS, Royal RE, Kammula US, Topalian SL, Sherry RM, Kleiner D, et al: Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. J Clin Oncol. 24:2283–2289. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Ibrahim RA, Berman DM, DePril V, Humphrey RW, Chen T, Messina M, Chin KM, Liu HY, Bielefield M and Hoos A: Ipilimumab safety profile: Summary of findings from completed trials in advanced melanoma. J Clin Oncol. 29:2011. View Article : Google Scholar

25 

Robert C, Ribas A, Wolchok JD, Hodi FS, Hamid O, Kefford R, Weber JS, Joshua AM, Hwu WJ, Gangadhar TC, et al: Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a phase 1 trial. Lancet. 384:1109–1117. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Zimmer L, Goldinger SM, Hofmann L, Loquai C, Ugurel S, Thomas I, Schmidgen MI, Gutzmer R, Utikal JS, Göppner D, et al: Neurological, respiratory, musculoskeletal, cardiac and ocular side-effects of anti-PD-1 therapy. Eur J Cancer. 60:210–225. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Faje A: Immunotherapy and hypophysitis: Clinical presentation, treatment and biologic insights. Pituitary. 19:82–92. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Hofmann L, Forschner A, Loquai C, Goldinger SM, Zimmer L, Ugurel S, Schmidgen MI, Gutzmer R, Utikal JS, Göppner D, et al: Cutaneous, gastrointestinal, hepatic, endocrine and renal side-effects of anti-PD-1 therapy. Eur J Cancer. 60:190–209. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Barjaktarevic IZ, Qadir N, Suri A, Santamauro JT and Stover D: Organizing pneumonia as a side effect of ipilimumab treatment of melanoma. Chest. 143:858–861. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Abdel-Rahman O and Fouad M: Risk of pneumonitis in cancer patients treated with immune checkpoint inhibitors: A meta-analysis. Ther Adv Respir Dis. 10:183–193. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Papavasileiou E, Prasad S, Freitag SK, Sobrin L and Lobo AM: Ipilimumab-induced ocular and orbital inflammation-A case series and review of the literature. Ocul Immunol Inflamm. 24:140–146. 2016.PubMed/NCBI

32 

Bot I, Blank CU, Boogerd W and Brandsma D: Neurological immune-related adverse events of ipilimumab. Pract Neurol. 13:278–280. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Cappelli LC, Shah AA and Bingham CO III: Immune-related adverse effects of cancer immunotherapy-implications for rheumatology. Rheum Dis Clin North Am. 43:65–78. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Goldstein BL, Gedmintas L and Todd DJ: Drug-associated polymyalgia rheumatica/giant cell arteritis occurring in two patients after treatment with ipilimumab, an antagonist of ctla-4. Arthritis Rheumatol. 66:768–769. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Fadel F, El Karoui K and Knebelmann B: Anti-CTLA4 antibody-induced lupus nephritis. N Engl J Med. 361:211–212. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Forde PM, Rock K, Wilson G and O'Byrne KJ: Ipilimumab-induced immune-related renal failure-a case report. Anticancer Res. 32:4607–4608. 2012.PubMed/NCBI

37 

Gordon IO, Wade T, Chin K, Dickstein J and Gajewski TF: Immune-mediated red cell aplasia after anti-CTLA-4 immunotherapy for metastatic melanoma. Cancer Immunol Immunother. 58:1351–1353. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Guo Y and Wang AY: Novel immune check-point regulators in tolerance maintenance. Fron Immunol. 6:4212015.

39 

Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB, Hunter KM, Smith AN, Di Genova G, et al: Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature. 423:506–511. 2003. View Article : Google Scholar : PubMed/NCBI

40 

Jin P, Xiang B, Huang G and Zhou Z: The association of cytotoxic T-lymphocyte antigen-4 + 49A/G and CT60 polymorphisms with type 1 diabetes and latent autoimmune diabetes in Chinese adults. J Endocrinol Invest. 38:149–154. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Kaehler KC, Piel S, Livingstone E, Schilling B, Hauschild A and Schadendorf D: Update on immunologic therapy with anti-CTLA-4 antibodies in melanoma: Identification of clinical and biological response patterns, immune-related adverse events, and their management. Semin Oncol. 37:485–498. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Berman D, Parker SM, Siegel J, Chasalow SD, Weber J, Galbraith S, Targan SR and Wang HL: Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma. Cancer Immun. 10:112010.PubMed/NCBI

43 

Nancey S, Boschetti G, Cotte E, Ruel K, Almeras T, Chauvenet M, Stroeymeyt K, Moussata D, Kaiserlian D and Flourié B: Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab is associated with a profound long-lasting depletion of Foxp3+ regulatory T cells: A mechanistic explanation for ipilimumab-induced severe enterocolitis? Inflamm Bowel Dis. 18:E1598–E1600. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Lord JD, Hackman RC, Moklebust A, Thompson JA, Higano CS, Chielens D, Steinbach G and McDonald GB: Refractory colitis following anti-CTLA4 antibody therapy: Analysis of mucosal FOXP3+ T cells. Dig Dis Sci. 55:1396–1405. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Callahan MK, Yang A, Tandon S, Xu Y, Subudhi SK, Roman RA, Heine AI, Pogoriler E, Kuk D, Panageas K, et al: Evaluation of serum IL-17 levels during ipilimumab therapy: Correlation with colitis. J Clin Oncol. 29:2011. View Article : Google Scholar

46 

Kähler KC and Hauschild A: Treatment and side effect management of CTLA-4 antibody therapy in metastatic melanoma. J Dtsch Dermatol Ges. 9:277–286. 2011.(In English, German). View Article : Google Scholar : PubMed/NCBI

47 

Lacouture ME, Wolchok JD, Yosipovitch G, Kähler KC, Busam KJ and Hauschild A: Ipilimumab in patients with cancer and the management of dermatologic adverse events. J Am Acad Dermatol. 71:161–169. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Weber J, Thompson JA, Hamid O, Minor D, Amin A, Ron I, Ridolfi R, Assi H, Maraveyas A, Berman D, et al: A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma. Clin Cancer Res. 15:5591–5598. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Weber JS, Kähler KC and Hauschild A: Management of immune-related adverse events and kinetics of response with ipilimumab. J Clin Oncol. 30:2691–2697. 2012. View Article : Google Scholar : PubMed/NCBI

50 

Villadolid J and Amin A: Immune checkpoint inhibitors in clinical practice: Update on management of immune-related toxicities. Transl Lung Cancer Res. 4:560–575. 2015.PubMed/NCBI

51 

Weber JS, Berman D, Siegel J, Minor D, Amin A, Thompson JA, Ron I, Ridolfi R, Assi H and Hamid O: Safety and efficacy of ipilimumab with or without prophylactic budesonide in treatment-naive and previously treated patients with advanced melanoma. J Clin Oncol. 2008. View Article : Google Scholar

52 

Spain L, Diem S and Larkin J: Management of toxicities of immune checkpoint inhibitors. Cancer Treat Rev. 44:51–60. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Friedman CF, Proverbs-Singh TA and Postow MA: Treatment of the immune-related adverse effects of immune checkpoint inhibitors: A review. JAMA Oncol. 2:1346–1353. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Sanlorenzo M, Vujic I, Daud A, Algazi A, Gubens M, Luna SA, Lin K, Quaglino P, Rappersberger K and Ortiz-Urda S: Pembrolizumab cutaneous adverse events and their association with disease progression. JAMA Dermatol. 151:1206–1212. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Lacouture ME: Management of dermatologic toxicities. J Natl Compr Canc Netw. 13 5 Suppl:S686–S689. 2015. View Article : Google Scholar

56 

Khunger M, Rakshit S, Pasupuleti V, Hernandez AV, Mazzone P, Stevenson J, Pennell NA and Velcheti V: Incidence of pneumonitis with use of PD-1 and PD-L1 inhibitors in non-small cell lung cancer: A systematic review and meta-analysis of trials. Chest. 152:271–281. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Tirumani SH, Ramaiya NH, Keraliya A, Bailey ND, Ott PA, Hodi FS and Nishino M: Radiographic profiling of immune-related adverse events in advanced melanoma patients treated with ipilimumab. Cancer Immunol Res. 3:1185–1192. 2015. View Article : Google Scholar : PubMed/NCBI

58 

Nishino M, Chambers ES, Chong CR, Ramaiya NH, Gray SW, Marcoux JP, Hatabu H, Jänne PA, Hodi FS and Awad MM: Anti-PD-1 inhibitor-related pneumonitis in non-small cell lung cancer. Cancer Immunol Res. 4:289–293. 2016. View Article : Google Scholar : PubMed/NCBI

59 

Dillard T, Yedinak CG, Alumkal J and Fleseriu M: Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: Serious immune related adverse events across a spectrum of cancer subtypes. Pituitary. 13:29–38. 2010. View Article : Google Scholar : PubMed/NCBI

60 

Lammert A, Schneider HJ, Bergmann T, Benck U, Krämer BK, Gärtner R, Metzner C, Schöfl C and Berking C: Hypophysitis caused by ipilimumab in cancer patients: Hormone replacement or immunosuppressive therapy. Exp Clin Endocrinol Diabetes. 121:581–587. 2013. View Article : Google Scholar : PubMed/NCBI

61 

González-Rodríguez E and Rodríguez-Abreu D: Spanish Group for Cancer Immuno-Biotherapy (GETICA): Immune checkpoint inhibitors: Review and management of endocrine adverse events. Oncologist. 21:804–816. 2016. View Article : Google Scholar : PubMed/NCBI

62 

Orlov S, Salari F, Kashat L and Walfish PG: Induction of painless thyroiditis in patients receiving programmed death 1 receptor immunotherapy for metastatic malignancies. J Clin Endocrinol Metab. 100:1738–1741. 2015. View Article : Google Scholar : PubMed/NCBI

63 

Amin A, DePril V, Hamid O, Wolchock J, Maio M, Neyns B, Chin K, Ibrahim R, Hoos A and O'Day S: Evaluation of the effect of systemic corticosteroids for the treatment of immune-related adverse events (irAEs) on the development or maintenance of ipilimumab clinical activity. J Clin Oncol. 27:2009.PubMed/NCBI

64 

Suarez-Almazor ME, Kim ST, Abdel-Wahab N and Diab A: Review: Immune-related adverse events with use of checkpoint inhibitors for immunotherapy of cancer. Arthritis Rheumatol. 69:687–699. 2017. View Article : Google Scholar : PubMed/NCBI

65 

Joshi S, Pantalena LC, Liu XK, Gaffen SL, Liu H, Rohowsky-Kochan C, Ichiyama K, Yoshimura A, Steinman L, Christakos S and Youssef S: 1,25-dihydroxyvitamin D (3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A. Mol Cell Biol. 31:3653–3669. 2011. View Article : Google Scholar : PubMed/NCBI

66 

Deeb KK, Trump DL and Johnson CS: Vitamin D signalling pathways in cancer: Potential for anticancer therapeutics. Nat Rev Cancer. 7:684–700. 2007. View Article : Google Scholar : PubMed/NCBI

67 

Roy S and Trinchieri G: Microbiota: A key orchestrator of cancer therapy. Nat Rev Cancer. 17:271–285. 2017. View Article : Google Scholar : PubMed/NCBI

68 

Vétizou M, Pitt JM, Daillère R, Lepage P, Waldschmitt N, Flament C, Rusakiewicz S, Routy B, Roberti MP, Duong CP, et al: Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science. 350:1079–1084. 2015. View Article : Google Scholar : PubMed/NCBI

69 

Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, Benyamin FW, Lei YM, Jabri B, Alegre ML, et al: Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science. 350:1084–1089. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Stucci S, Palmirotta R, Passarelli A, Silvestris E, Argentiero A, Lanotte L, Acquafredda S, Todisco A and Silvestris F: Immune‑related adverse events during anticancer immunotherapy: Pathogenesis and management (Review). Oncol Lett 14: 5671-5680, 2017.
APA
Stucci, S., Palmirotta, R., Passarelli, A., Silvestris, E., Argentiero, A., Lanotte, L. ... Silvestris, F. (2017). Immune‑related adverse events during anticancer immunotherapy: Pathogenesis and management (Review). Oncology Letters, 14, 5671-5680. https://doi.org/10.3892/ol.2017.6919
MLA
Stucci, S., Palmirotta, R., Passarelli, A., Silvestris, E., Argentiero, A., Lanotte, L., Acquafredda, S., Todisco, A., Silvestris, F."Immune‑related adverse events during anticancer immunotherapy: Pathogenesis and management (Review)". Oncology Letters 14.5 (2017): 5671-5680.
Chicago
Stucci, S., Palmirotta, R., Passarelli, A., Silvestris, E., Argentiero, A., Lanotte, L., Acquafredda, S., Todisco, A., Silvestris, F."Immune‑related adverse events during anticancer immunotherapy: Pathogenesis and management (Review)". Oncology Letters 14, no. 5 (2017): 5671-5680. https://doi.org/10.3892/ol.2017.6919
Copy and paste a formatted citation
x
Spandidos Publications style
Stucci S, Palmirotta R, Passarelli A, Silvestris E, Argentiero A, Lanotte L, Acquafredda S, Todisco A and Silvestris F: Immune‑related adverse events during anticancer immunotherapy: Pathogenesis and management (Review). Oncol Lett 14: 5671-5680, 2017.
APA
Stucci, S., Palmirotta, R., Passarelli, A., Silvestris, E., Argentiero, A., Lanotte, L. ... Silvestris, F. (2017). Immune‑related adverse events during anticancer immunotherapy: Pathogenesis and management (Review). Oncology Letters, 14, 5671-5680. https://doi.org/10.3892/ol.2017.6919
MLA
Stucci, S., Palmirotta, R., Passarelli, A., Silvestris, E., Argentiero, A., Lanotte, L., Acquafredda, S., Todisco, A., Silvestris, F."Immune‑related adverse events during anticancer immunotherapy: Pathogenesis and management (Review)". Oncology Letters 14.5 (2017): 5671-5680.
Chicago
Stucci, S., Palmirotta, R., Passarelli, A., Silvestris, E., Argentiero, A., Lanotte, L., Acquafredda, S., Todisco, A., Silvestris, F."Immune‑related adverse events during anticancer immunotherapy: Pathogenesis and management (Review)". Oncology Letters 14, no. 5 (2017): 5671-5680. https://doi.org/10.3892/ol.2017.6919
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