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November-2017 Volume 14 Issue 5

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International Journal of Molecular Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article Open Access

Silencing of semaphorin 3C suppresses cell proliferation and migration in MCF‑7 breast cancer cells

  • Authors:
    • Xiaofang Zhu
    • Xiangjian Zhang
    • Zhiqiang Ye
    • Yizuo Chen
    • Lin Lv
    • Xiaohua Zhang
    • Hongye Hu
  • View Affiliations / Copyright

    Affiliations: Department of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5913-5917
    |
    Published online on: September 8, 2017
       https://doi.org/10.3892/ol.2017.6920
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Abstract

Previous studies have suggested that semaphorin 3C (SEMA3C) is involved in the tumorigenesis and metastasis of a number of types of cancer. The aim of the present study was to investigate the role of SEMA3C in the proliferation and migration of MCF‑7 breast cancer cells. Small interfering (si)RNA sequences targeting SEMA3C were constructed and transfected into MCF‑7 cells in order to silence the expression of SEMA3C. Cell proliferation and migration were measured using CCK‑8 and Transwell assays, respectively. Transfection with SEMA3C siRNA significantly downregulated the expression of SEMA3C in MCF‑7 cells, and significantly suppressed cell proliferation and migration. Therefore, SEMA3C‑targeted siRNA may be of potential use for the early diagnosis and treatment of breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu X, Zhang X, Ye Z, Chen Y, Lv L, Zhang X and Hu H: Silencing of semaphorin 3C suppresses cell proliferation and migration in MCF‑7 breast cancer cells. Oncol Lett 14: 5913-5917, 2017.
APA
Zhu, X., Zhang, X., Ye, Z., Chen, Y., Lv, L., Zhang, X., & Hu, H. (2017). Silencing of semaphorin 3C suppresses cell proliferation and migration in MCF‑7 breast cancer cells. Oncology Letters, 14, 5913-5917. https://doi.org/10.3892/ol.2017.6920
MLA
Zhu, X., Zhang, X., Ye, Z., Chen, Y., Lv, L., Zhang, X., Hu, H."Silencing of semaphorin 3C suppresses cell proliferation and migration in MCF‑7 breast cancer cells". Oncology Letters 14.5 (2017): 5913-5917.
Chicago
Zhu, X., Zhang, X., Ye, Z., Chen, Y., Lv, L., Zhang, X., Hu, H."Silencing of semaphorin 3C suppresses cell proliferation and migration in MCF‑7 breast cancer cells". Oncology Letters 14, no. 5 (2017): 5913-5917. https://doi.org/10.3892/ol.2017.6920
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu X, Zhang X, Ye Z, Chen Y, Lv L, Zhang X and Hu H: Silencing of semaphorin 3C suppresses cell proliferation and migration in MCF‑7 breast cancer cells. Oncol Lett 14: 5913-5917, 2017.
APA
Zhu, X., Zhang, X., Ye, Z., Chen, Y., Lv, L., Zhang, X., & Hu, H. (2017). Silencing of semaphorin 3C suppresses cell proliferation and migration in MCF‑7 breast cancer cells. Oncology Letters, 14, 5913-5917. https://doi.org/10.3892/ol.2017.6920
MLA
Zhu, X., Zhang, X., Ye, Z., Chen, Y., Lv, L., Zhang, X., Hu, H."Silencing of semaphorin 3C suppresses cell proliferation and migration in MCF‑7 breast cancer cells". Oncology Letters 14.5 (2017): 5913-5917.
Chicago
Zhu, X., Zhang, X., Ye, Z., Chen, Y., Lv, L., Zhang, X., Hu, H."Silencing of semaphorin 3C suppresses cell proliferation and migration in MCF‑7 breast cancer cells". Oncology Letters 14, no. 5 (2017): 5913-5917. https://doi.org/10.3892/ol.2017.6920
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