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SPARC inhibits breast cancer bone metastasis and may be a clinical therapeutic target

  • Authors:
    • Jingjing Ma
    • Sheng Gao
    • Xiju Xie
    • Erhu Sun
    • Min Zhang
    • Qian Zhou
    • Cheng Lu
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Reproductive Medicine, Department of Breast Surgery, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5876-5882
    |
    Published online on: September 14, 2017
       https://doi.org/10.3892/ol.2017.6925
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Abstract

Breast cancer is one of the most common types of cancer in females worldwide, and metastasis to bone is an important characteristic of malignancy. The present study aimed to investigate the molecular mechanism of breast cancer to bone metastasis of secreted protein acidic and rich in cysteine (SPARC). Immunohistochemistry was performed to examine the expression of SPARC in primary breast tumors and bone metastatic foci. Western blotting and reverse transcription‑quantitative polymerase chain reaction were performed to detect the expression level of SPARC in several types of breast cancer cell. A Transwell filter assay was used to assess the effect of SPARC on breast cancer cell invasion ability, and an osteoblast differentiation assay was employed to analyze the effect of SPARC on the differentiation ability of mesenchymal stem cells. Clinical data revealed that decreased stromal SPARC expression is associated with breast cancer to bone metastasis. Gain‑ and loss‑of‑function studies reveal that SPARC inhibits the migration and invasion of breast cancer cells, and suppresses osteoclast activation in the breast cancer microenvironment. SPARC serves an important role in breast cancer bone metastasis and may be a promising therapeutic target for the treatment of breast cancer bone metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Ma J, Gao S, Xie X, Sun E, Zhang M, Zhou Q and Lu C: SPARC inhibits breast cancer bone metastasis and may be a clinical therapeutic target. Oncol Lett 14: 5876-5882, 2017.
APA
Ma, J., Gao, S., Xie, X., Sun, E., Zhang, M., Zhou, Q., & Lu, C. (2017). SPARC inhibits breast cancer bone metastasis and may be a clinical therapeutic target. Oncology Letters, 14, 5876-5882. https://doi.org/10.3892/ol.2017.6925
MLA
Ma, J., Gao, S., Xie, X., Sun, E., Zhang, M., Zhou, Q., Lu, C."SPARC inhibits breast cancer bone metastasis and may be a clinical therapeutic target". Oncology Letters 14.5 (2017): 5876-5882.
Chicago
Ma, J., Gao, S., Xie, X., Sun, E., Zhang, M., Zhou, Q., Lu, C."SPARC inhibits breast cancer bone metastasis and may be a clinical therapeutic target". Oncology Letters 14, no. 5 (2017): 5876-5882. https://doi.org/10.3892/ol.2017.6925
Copy and paste a formatted citation
x
Spandidos Publications style
Ma J, Gao S, Xie X, Sun E, Zhang M, Zhou Q and Lu C: SPARC inhibits breast cancer bone metastasis and may be a clinical therapeutic target. Oncol Lett 14: 5876-5882, 2017.
APA
Ma, J., Gao, S., Xie, X., Sun, E., Zhang, M., Zhou, Q., & Lu, C. (2017). SPARC inhibits breast cancer bone metastasis and may be a clinical therapeutic target. Oncology Letters, 14, 5876-5882. https://doi.org/10.3892/ol.2017.6925
MLA
Ma, J., Gao, S., Xie, X., Sun, E., Zhang, M., Zhou, Q., Lu, C."SPARC inhibits breast cancer bone metastasis and may be a clinical therapeutic target". Oncology Letters 14.5 (2017): 5876-5882.
Chicago
Ma, J., Gao, S., Xie, X., Sun, E., Zhang, M., Zhou, Q., Lu, C."SPARC inhibits breast cancer bone metastasis and may be a clinical therapeutic target". Oncology Letters 14, no. 5 (2017): 5876-5882. https://doi.org/10.3892/ol.2017.6925
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