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Article

Regulatory network involving miRNAs and genes in serous ovarian carcinoma

  • Authors:
    • Haiyan Zhao
    • Hao Xu
    • Luchen Xue
  • View Affiliations / Copyright

    Affiliations: College of Computer Science and Technology, Jilin University, Changchun, Jilin 130012, P.R. China, College of Software, Jilin University, Changchun, Jilin 130012, P.R. China
  • Pages: 6259-6268
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    Published online on: September 14, 2017
       https://doi.org/10.3892/ol.2017.6927
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Abstract

Serous ovarian carcinoma (SOC) is one of the most life‑threatening types of gynecological malignancy, but the pathogenesis of SOC remains unknown. Previous studies have indicated that differentially expressed genes and microRNAs (miRNAs) serve important functions in SOC. However, genes and miRNAs are identified in a disperse form, and limited information is known about the regulatory association between miRNAs and genes in SOC. In the present study, three regulatory networks were hierarchically constructed, including a differentially‑expressed network, a related network and a global network to reveal associations between each factor. In each network, there were three types of factors, which were genes, miRNAs and transcription factors that interact with each other. Focus was placed on the differentially‑expressed network, in which all genes and miRNAs were differentially expressed and therefore may have affected the development of SOC. Following the comparison and analysis between the three networks, a number of signaling pathways which demonstrated differentially expressed elements were highlighted. Subsequently, the upstream and downstream elements of differentially expressed miRNAs and genes were listed, and a number of key elements (differentially expressed miRNAs, genes and TFs predicted using the P‑match method) were analyzed. The differentially expressed network partially illuminated the pathogenesis of SOC. It was hypothesized that if there was no differential expression of miRNAs and genes, SOC may be prevented and treatment may be identified. The present study provided a theoretical foundation for gene therapy for SOC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao H, Xu H and Xue L: Regulatory network involving miRNAs and genes in serous ovarian carcinoma. Oncol Lett 14: 6259-6268, 2017.
APA
Zhao, H., Xu, H., & Xue, L. (2017). Regulatory network involving miRNAs and genes in serous ovarian carcinoma. Oncology Letters, 14, 6259-6268. https://doi.org/10.3892/ol.2017.6927
MLA
Zhao, H., Xu, H., Xue, L."Regulatory network involving miRNAs and genes in serous ovarian carcinoma". Oncology Letters 14.5 (2017): 6259-6268.
Chicago
Zhao, H., Xu, H., Xue, L."Regulatory network involving miRNAs and genes in serous ovarian carcinoma". Oncology Letters 14, no. 5 (2017): 6259-6268. https://doi.org/10.3892/ol.2017.6927
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao H, Xu H and Xue L: Regulatory network involving miRNAs and genes in serous ovarian carcinoma. Oncol Lett 14: 6259-6268, 2017.
APA
Zhao, H., Xu, H., & Xue, L. (2017). Regulatory network involving miRNAs and genes in serous ovarian carcinoma. Oncology Letters, 14, 6259-6268. https://doi.org/10.3892/ol.2017.6927
MLA
Zhao, H., Xu, H., Xue, L."Regulatory network involving miRNAs and genes in serous ovarian carcinoma". Oncology Letters 14.5 (2017): 6259-6268.
Chicago
Zhao, H., Xu, H., Xue, L."Regulatory network involving miRNAs and genes in serous ovarian carcinoma". Oncology Letters 14, no. 5 (2017): 6259-6268. https://doi.org/10.3892/ol.2017.6927
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