Serum Golgi protein 73 is a prognostic rather than diagnostic marker in hepatocellular carcinoma

  • Authors:
    • Min Dong
    • Zhan‑Hong Chen
    • Xing Li
    • Xiao‑Yun Li
    • Jing‑Yun Wen
    • Qu Lin
    • Xiao‑Kun Ma
    • Li Wei
    • Jie Chen
    • Dan‑Yun Ruan
    • Ze‑Xiao Lin
    • Tian‑Tian Wang
    • Dong‑Hao Wu
    • Xiang‑Yuan Wu
  • View Affiliations

  • Published online on: September 14, 2017     https://doi.org/10.3892/ol.2017.6938
  • Pages: 6277-6284
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Abstract

Serum Golgi protein 73 (sGP73) is a candidate diagnostic biomarker for hepatocellular carcinoma (HCC). However, current evidence of its diagnostic value is conflicting, primarily due to the small sample sizes of previous studies, and its prognostic role in HCC also remains unclear. In the present study, sGP73 levels in 462 patients with HCC, 186 patients with liver cirrhosis, and 83 healthy controls were evaluated using ELISA, and it was identified that the median sGP73 levels were significantly higher in the HCC (18.7 ng/ml) and liver cirrhosis (18.5 ng/ml) patients than in the healthy controls (0 ng/ml; both P<0.001); however, the levels did not significantly differ between the HCC and liver cirrhosis groups (P=0.632). sGP73 had an inferior sensitivity and specificity for HCC diagnosis (27.79 and 77.96%, respectively) compared with α‑fetoprotein (57.36 and 90.96%, respectively; P<0.001). In the HCC group, a high level of sGP73 was associated with aggressive clinicopathological features and independently predicted poor overall survival (OS) time (P<0.001). Additionally, in patients with resectable HCC, a high level of sGP73 was associated with significantly decreased disease‑free survival (P<0.001) and OS (P=0.039) times compared with a low level of sGP73. This study demonstrated that sGP73 is unsuitable as a diagnostic marker for the early detection of HCC; however, it is an independent negative prognostic marker, providing a novel risk stratification factor and a potential therapeutic molecular target for HCC.
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November-2017
Volume 14 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Dong M, Chen ZH, Li X, Li XY, Wen JY, Lin Q, Ma XK, Wei L, Chen J, Ruan DY, Ruan DY, et al: Serum Golgi protein 73 is a prognostic rather than diagnostic marker in hepatocellular carcinoma. Oncol Lett 14: 6277-6284, 2017
APA
Dong, M., Chen, Z., Li, X., Li, X., Wen, J., Lin, Q. ... Wu, X. (2017). Serum Golgi protein 73 is a prognostic rather than diagnostic marker in hepatocellular carcinoma. Oncology Letters, 14, 6277-6284. https://doi.org/10.3892/ol.2017.6938
MLA
Dong, M., Chen, Z., Li, X., Li, X., Wen, J., Lin, Q., Ma, X., Wei, L., Chen, J., Ruan, D., Lin, Z., Wang, T., Wu, D., Wu, X."Serum Golgi protein 73 is a prognostic rather than diagnostic marker in hepatocellular carcinoma". Oncology Letters 14.5 (2017): 6277-6284.
Chicago
Dong, M., Chen, Z., Li, X., Li, X., Wen, J., Lin, Q., Ma, X., Wei, L., Chen, J., Ruan, D., Lin, Z., Wang, T., Wu, D., Wu, X."Serum Golgi protein 73 is a prognostic rather than diagnostic marker in hepatocellular carcinoma". Oncology Letters 14, no. 5 (2017): 6277-6284. https://doi.org/10.3892/ol.2017.6938