Biochanin A induces anticancer effects in SK‑Mel‑28 human malignant melanoma cells via induction of apoptosis, inhibition of cell invasion and modulation of NF‑κB and MAPK signaling pathways

Hussein MR, Haemel AK and Wood GS: Apoptosis and melanoma: Molecular mechanisms. J Pathol. 199:275–288. 2003. View Article : Google Scholar : PubMed/NCBI

Soengas MS and Lowe SW: Apoptosis and melanoma chemoresistance. Oncogene. 22:3138–3151. 2003. View Article : Google Scholar : PubMed/NCBI

Senderowicz AM: Novel small molecule cyclin-dependent kinases modulators in human clinical trials. Cancer Biol Ther. 2 4 Suppl 1:S84–S95. 2003. View Article : Google Scholar : PubMed/NCBI

Comis RL: DTIC (NSC-45388) in malignant melanoma: A perspective. Cancer Treat Rep. 60:165–176. 1976.PubMed/NCBI

McClay EF and McClay ME: Tamoxifen: Is it useful in the treatment of patients with metastatic melanoma? J Clin Oncol. 12:617–626. 1994. View Article : Google Scholar : PubMed/NCBI

Cragg GM, Boyd MR, Cardellina JH, Grever MR, Schepartz SA, Snader KM and Matthew S: Role of Plants in the National cancer Institute drug discovery and development program. ACS Symposium Series. 534:80–95. 2009.

Sehdev V, Lai JC and Bhushan A: Biochanin A modulates cell viability, invasion, and growth promoting signaling pathways in HER-2-positive breast cancer cells. J Oncol. 2009:1214582009. View Article : Google Scholar : PubMed/NCBI

Seo YJ, Kim BS, Chun SY, Park YK, Kang KS and Kwon TG: Apoptotic effects of genistein, biochanin-A and apigenin on LNCaP and PC-3 cells by p21 through transcriptional inhibition of polo-like kinase-1. J Korean Med Sci. 26:1489–1494. 2011. View Article : Google Scholar : PubMed/NCBI

Bhardwaj V, Tadinada SM, Jain A, Sehdev V, Daniels CK, Lai JC and Bhushan A: Biochanin A reduces pancreatic cancer survival and progression. Anticancer Drugs. 25:296–302. 2014. View Article : Google Scholar : PubMed/NCBI

Medjakovic S and Jungbauer A: Red clover isoflavones Biochanin A and formononetin are potent ligands of the human aryl hydrocarbon receptor. J Steroid Biochem Mol Biol. 108:171–177. 2008. View Article : Google Scholar : PubMed/NCBI

Hodek P, Trefil P and Stiborová M: Flavonoids-Potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact. 139:1–21. 2002. View Article : Google Scholar : PubMed/NCBI

Manthey JA, Guthrie N and Grohmann K: Biological properties of Citrus flavonoids Pertaining to cancer and inflammation. Curr Med Chem. 8:135–153. 2001. View Article : Google Scholar : PubMed/NCBI

Surh YJ: Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer. 3:768–780. 2003. View Article : Google Scholar : PubMed/NCBI

Galati G, Teng S, Moridani MY, Chan TS and Brien OPJ: Cancer chemoprevention and apoptosis mechanisms induced by dietary polyphenolics. Drug Metabol Drug Interact. 17:311–349. 2000. View Article : Google Scholar : PubMed/NCBI

Yang CS, Landau JM, Huang MT and Newmark HL: Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu Rev Nutr. 21:381–406. 2001. View Article : Google Scholar : PubMed/NCBI

Banday JA, Shah SA, Kanth AH, Farozi A and Wani H: In Vitro screening for anticancer activity of petroleum ether and ethyl acetate extracts of Conyza canedensis growing in Kashmir region. Adv Biomed Pharma. 2:82–85. 2015. View Article : Google Scholar

Park GB, Kim DJ, Kim YS, Lee HK, Kim CW and Hur DY: Silencing of galectin-3 represses osteosarcoma cell migration and invasion through inhibition of FAK/Src/Lyn activation and β-catenin expression and increases susceptibility to chemotherapeutic agents. Int J Oncol. 46:185–194. 2015. View Article : Google Scholar : PubMed/NCBI

Li X, Yang G, Li X, Zhang Y, Yang J, Chang J, Sun X, Zhou X, Guo Y, Xu Y, et al: Traditional Chinese medicine in cancer care: A review of controlled clinical studies published in Chinese. PLoS One. 8:e603382013. View Article : Google Scholar : PubMed/NCBI