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Article

Effect of pretreatment psoas muscle mass on survival for patients with unresectable pancreatic cancer undergoing systemic chemotherapy

  • Authors:
    • Noriko Ishii
    • Yoshinori Iwata
    • Hiroki Nishikawa
    • Hirayuki Enomoto
    • Nobuhiro Aizawa
    • Akio Ishii
    • Yuho Miyamoto
    • Yukihisa Yuri
    • Kunihiro Hasegawa
    • Chikage Nakano
    • Takashi Nishimura
    • Kazunori Yoh
    • Yoshiyuki Sakai
    • Naoto Ikeda
    • Tomoyuki Takashima
    • Ryo Takata
    • Hiroko Iijima
    • Shuhei Nishiguchi
  • View Affiliations / Copyright

    Affiliations: Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiyashi, Hyogo 663‑8501, Japan
  • Pages: 6059-6065
    |
    Published online on: September 15, 2017
       https://doi.org/10.3892/ol.2017.6952
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Abstract

To the best of our knowledge, there are few previous studies that have investigated the effect of decreased skeletal muscle mass (DSMM) on survival in patients with unresectable advanced pancreatic cancer (APC) who are undergoing systemic chemotherapy. Thus, the present study aimed to investigate the impact of DSMM, as determined by the psoas muscle index (PMI) following computed tomography and prior to systemic chemotherapy, on the outcomes of patients with unresectable APC (n=61). The primary endpoint used was the overall survival (OS) rate. The OS rates in the PMI‑High group (exceeds the median PMI value in each gender) were retrospectively compared with those in the PMI‑Low group (below the median PMI value in each gender), and factors associated with OS were investigated using univariate and multivariate analyses. The study cohort included 31 male and 30 female patients with a median age of 72 years, 13 of whom were stage IVA, and 48 were stage IVB. The median PMI in males was 4.3 cm2/m2 (range, 1.6‑8.2 cm2/m2), while that in females was 2.3 cm2/m2 (range, 0.7‑6.1 cm2/m2). The proportion of patients with performance status 0 in the PMI‑High group was significantly high, compared with that in the PMI‑Low group [83.3% (25/30) vs. 58.1% (18/31); P=0.0486]. Body mass index in the PMI‑High group was significantly higher compared with that in the PMI‑Low group (P=0.0154). The 1‑year cumulative survival rate was 43.3% in the PMI‑High group and 12.9% in the PMI‑Low group (P=0.0027). Following multivariate analysis, PMI (P=0.0036), prothrombin time (P=0.0044) and carbohydrate antigen 19‑9 (P=0.0451) were identified to be significant predictors of OS. In conclusion, DSMM, as determined by the PMI, could be a significant predictor of prognosis in patients with unresectable APC who are receiving systemic chemotherapy.
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Copy and paste a formatted citation
Spandidos Publications style
Ishii N, Iwata Y, Nishikawa H, Enomoto H, Aizawa N, Ishii A, Miyamoto Y, Yuri Y, Hasegawa K, Nakano C, Nakano C, et al: Effect of pretreatment psoas muscle mass on survival for patients with unresectable pancreatic cancer undergoing systemic chemotherapy. Oncol Lett 14: 6059-6065, 2017.
APA
Ishii, N., Iwata, Y., Nishikawa, H., Enomoto, H., Aizawa, N., Ishii, A. ... Nishiguchi, S. (2017). Effect of pretreatment psoas muscle mass on survival for patients with unresectable pancreatic cancer undergoing systemic chemotherapy. Oncology Letters, 14, 6059-6065. https://doi.org/10.3892/ol.2017.6952
MLA
Ishii, N., Iwata, Y., Nishikawa, H., Enomoto, H., Aizawa, N., Ishii, A., Miyamoto, Y., Yuri, Y., Hasegawa, K., Nakano, C., Nishimura, T., Yoh, K., Sakai, Y., Ikeda, N., Takashima, T., Takata, R., Iijima, H., Nishiguchi, S."Effect of pretreatment psoas muscle mass on survival for patients with unresectable pancreatic cancer undergoing systemic chemotherapy". Oncology Letters 14.5 (2017): 6059-6065.
Chicago
Ishii, N., Iwata, Y., Nishikawa, H., Enomoto, H., Aizawa, N., Ishii, A., Miyamoto, Y., Yuri, Y., Hasegawa, K., Nakano, C., Nishimura, T., Yoh, K., Sakai, Y., Ikeda, N., Takashima, T., Takata, R., Iijima, H., Nishiguchi, S."Effect of pretreatment psoas muscle mass on survival for patients with unresectable pancreatic cancer undergoing systemic chemotherapy". Oncology Letters 14, no. 5 (2017): 6059-6065. https://doi.org/10.3892/ol.2017.6952
Copy and paste a formatted citation
x
Spandidos Publications style
Ishii N, Iwata Y, Nishikawa H, Enomoto H, Aizawa N, Ishii A, Miyamoto Y, Yuri Y, Hasegawa K, Nakano C, Nakano C, et al: Effect of pretreatment psoas muscle mass on survival for patients with unresectable pancreatic cancer undergoing systemic chemotherapy. Oncol Lett 14: 6059-6065, 2017.
APA
Ishii, N., Iwata, Y., Nishikawa, H., Enomoto, H., Aizawa, N., Ishii, A. ... Nishiguchi, S. (2017). Effect of pretreatment psoas muscle mass on survival for patients with unresectable pancreatic cancer undergoing systemic chemotherapy. Oncology Letters, 14, 6059-6065. https://doi.org/10.3892/ol.2017.6952
MLA
Ishii, N., Iwata, Y., Nishikawa, H., Enomoto, H., Aizawa, N., Ishii, A., Miyamoto, Y., Yuri, Y., Hasegawa, K., Nakano, C., Nishimura, T., Yoh, K., Sakai, Y., Ikeda, N., Takashima, T., Takata, R., Iijima, H., Nishiguchi, S."Effect of pretreatment psoas muscle mass on survival for patients with unresectable pancreatic cancer undergoing systemic chemotherapy". Oncology Letters 14.5 (2017): 6059-6065.
Chicago
Ishii, N., Iwata, Y., Nishikawa, H., Enomoto, H., Aizawa, N., Ishii, A., Miyamoto, Y., Yuri, Y., Hasegawa, K., Nakano, C., Nishimura, T., Yoh, K., Sakai, Y., Ikeda, N., Takashima, T., Takata, R., Iijima, H., Nishiguchi, S."Effect of pretreatment psoas muscle mass on survival for patients with unresectable pancreatic cancer undergoing systemic chemotherapy". Oncology Letters 14, no. 5 (2017): 6059-6065. https://doi.org/10.3892/ol.2017.6952
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