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Article Open Access

Eupatolide inhibits the TGF‑β1‑induced migration of breast cancer cells via downregulation of SMAD3 phosphorylation and transcriptional repression of ALK5

Corrigendum in: /10.3892/ol.2018.8427
  • Authors:
    • Ariundavaa Boldbaatar
    • Sunyi Lee
    • Sora Han
    • Ae Lee Jeong
    • Hye In Ka
    • Sumiyasuren Buyanravjikh
    • Jeong Hyung Lee
    • Jong‑Seok Lim
    • Myung Sok Lee
    • Young Yang
  • View Affiliations / Copyright

    Affiliations: Graduate School of Biological Science, Sookmyung Women's University, Seoul 04310, Republic of Korea, Research Center for Women's Disease, Department of Biological Science, Sookmyung Women's University, Seoul 04310, Republic of Korea, Department of Biochemistry, Kangwon National University, Chuncheon 24341, Republic of Korea, Department of Biological Science, Sookmyung Women's University, Seoul 04310, Republic of Korea
    Copyright: © Boldbaatar et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6031-6039
    |
    Published online on: September 15, 2017
       https://doi.org/10.3892/ol.2017.6957
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Abstract

The epithelial‑mesenchymal transition (EMT) is a hallmark of cancer metastasis, and the associated molecular signaling pathways are regarded as therapeutic targets for cancer treatment. Thus, suppressing EMT with a natural chemical compound may be of therapeutic benefit. Eupatolide is a natural chemical compound extracted from the medicinal plant Inula britannica, which is used in Eastern Asia to treat bronchitis, disorders of the digestive system and inflammation. Besides the anti‑inflammatory function of eupatolide, the present study found that eupatolide suppressed the migration and invasion of breast cancer cells, which was associated with the downregulation of vimentin in MDA‑MB‑231 cells and the upregulation of E‑cadherin in MCF‑7 cells. Treatment with eupatolide also significantly inhibited the migration and invasion of breast cancer cells that had been stimulated with transforming growth factor‑β1 (TGF‑β1). Eupatolide also suppressed TGF‑β1‑induced EMT via downregulation of mothers against decapentaplegic homolog 3 (SMAD3) phosphorylation and transcriptional repression of TGF‑β receptor 1 (ALK5). In addition to this canonical pathway, the non‑canonical protein kinase B (AKT) and extracellular signal‑regulated kinase (ERK) pathways were also inhibited by eupatolide treatment. In summary, the results suggest that eupatolide suppresses the migration and invasion of breast cancer cells by blocking the canonical ALK5‑SMAD3 signaling pathway and the non‑canonical ERK and AKT signaling pathways.
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Copy and paste a formatted citation
Spandidos Publications style
Boldbaatar A, Lee S, Han S, Jeong AL, Ka HI, Buyanravjikh S, Lee JH, Lim JS, Lee MS, Yang Y, Yang Y, et al: Eupatolide inhibits the TGF‑β1‑induced migration of breast cancer cells via downregulation of SMAD3 phosphorylation and transcriptional repression of ALK5 Corrigendum in /10.3892/ol.2018.8427. Oncol Lett 14: 6031-6039, 2017.
APA
Boldbaatar, A., Lee, S., Han, S., Jeong, A.L., Ka, H.I., Buyanravjikh, S. ... Yang, Y. (2017). Eupatolide inhibits the TGF‑β1‑induced migration of breast cancer cells via downregulation of SMAD3 phosphorylation and transcriptional repression of ALK5 Corrigendum in /10.3892/ol.2018.8427. Oncology Letters, 14, 6031-6039. https://doi.org/10.3892/ol.2017.6957
MLA
Boldbaatar, A., Lee, S., Han, S., Jeong, A. L., Ka, H. I., Buyanravjikh, S., Lee, J. H., Lim, J., Lee, M. S., Yang, Y."Eupatolide inhibits the TGF‑β1‑induced migration of breast cancer cells via downregulation of SMAD3 phosphorylation and transcriptional repression of ALK5 Corrigendum in /10.3892/ol.2018.8427". Oncology Letters 14.5 (2017): 6031-6039.
Chicago
Boldbaatar, A., Lee, S., Han, S., Jeong, A. L., Ka, H. I., Buyanravjikh, S., Lee, J. H., Lim, J., Lee, M. S., Yang, Y."Eupatolide inhibits the TGF‑β1‑induced migration of breast cancer cells via downregulation of SMAD3 phosphorylation and transcriptional repression of ALK5 Corrigendum in /10.3892/ol.2018.8427". Oncology Letters 14, no. 5 (2017): 6031-6039. https://doi.org/10.3892/ol.2017.6957
Copy and paste a formatted citation
x
Spandidos Publications style
Boldbaatar A, Lee S, Han S, Jeong AL, Ka HI, Buyanravjikh S, Lee JH, Lim JS, Lee MS, Yang Y, Yang Y, et al: Eupatolide inhibits the TGF‑β1‑induced migration of breast cancer cells via downregulation of SMAD3 phosphorylation and transcriptional repression of ALK5 Corrigendum in /10.3892/ol.2018.8427. Oncol Lett 14: 6031-6039, 2017.
APA
Boldbaatar, A., Lee, S., Han, S., Jeong, A.L., Ka, H.I., Buyanravjikh, S. ... Yang, Y. (2017). Eupatolide inhibits the TGF‑β1‑induced migration of breast cancer cells via downregulation of SMAD3 phosphorylation and transcriptional repression of ALK5 Corrigendum in /10.3892/ol.2018.8427. Oncology Letters, 14, 6031-6039. https://doi.org/10.3892/ol.2017.6957
MLA
Boldbaatar, A., Lee, S., Han, S., Jeong, A. L., Ka, H. I., Buyanravjikh, S., Lee, J. H., Lim, J., Lee, M. S., Yang, Y."Eupatolide inhibits the TGF‑β1‑induced migration of breast cancer cells via downregulation of SMAD3 phosphorylation and transcriptional repression of ALK5 Corrigendum in /10.3892/ol.2018.8427". Oncology Letters 14.5 (2017): 6031-6039.
Chicago
Boldbaatar, A., Lee, S., Han, S., Jeong, A. L., Ka, H. I., Buyanravjikh, S., Lee, J. H., Lim, J., Lee, M. S., Yang, Y."Eupatolide inhibits the TGF‑β1‑induced migration of breast cancer cells via downregulation of SMAD3 phosphorylation and transcriptional repression of ALK5 Corrigendum in /10.3892/ol.2018.8427". Oncology Letters 14, no. 5 (2017): 6031-6039. https://doi.org/10.3892/ol.2017.6957
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