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Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer

  • Authors:
    • Shizhen Zhang
    • Rui Lei
    • Jingjing Wu
    • Jinlan Shan
    • Zujian Hu
    • Lirong Chen
    • Xingchang Ren
    • Lifang Yao
    • Jian Wang
    • Xiaochen Wang
  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Plastic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China, Department of Pathology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Breast Surgery, Hangzhou Traditional Chinese Medical Hospital, Hangzhou, Zhejiang 310000, P.R. China, Department of Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Pathology, Hangzhou Traditional Chinese Medical Hospital, Hangzhou, Zhejiang 310000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5719-5726
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    Published online on: September 15, 2017
       https://doi.org/10.3892/ol.2017.6963
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Abstract

The high mobility group A1 (HMGA1) protein is associated with poor prognosis in patients with a wide range of cancers. However, the affect of HMGA1 on the risk of mortality from breast cancer (BC) has not been fully characterized. In the present retrospective multiple center study, the HMGA1 expression level was determined by performing immunohistochemistry on surgical tissue samples of 273 BC specimens from the Second Affiliated Hospital of Zhejiang University (Zhejiang, China) and 310 BCs from the National Engineering Center for Biochip (Shanghai, China). Kaplan‑Meier analysis and Cox proportional hazard model were employed to analyze the survivability. HMGA1 expression was significantly associated with tumor histological degree and body mass index (BMI). However, HMGA1 expression showed no prognostic value in patients with BC. Combined evaluation of HMGA1 expression and high BMI (≥24 kg/m2) predicted worse overall survival of BC. Therefore, HMGA1 and BMI were considered to serve synergistic roles in the development and progression of BC, and combined evaluation of HMGA1 expression and high BMI may be an effective marker in predicting poor prognosis of BC patients.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang S, Lei R, Wu J, Shan J, Hu Z, Chen L, Ren X, Yao L, Wang J, Wang X, Wang X, et al: Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer. Oncol Lett 14: 5719-5726, 2017.
APA
Zhang, S., Lei, R., Wu, J., Shan, J., Hu, Z., Chen, L. ... Wang, X. (2017). Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer. Oncology Letters, 14, 5719-5726. https://doi.org/10.3892/ol.2017.6963
MLA
Zhang, S., Lei, R., Wu, J., Shan, J., Hu, Z., Chen, L., Ren, X., Yao, L., Wang, J., Wang, X."Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer". Oncology Letters 14.5 (2017): 5719-5726.
Chicago
Zhang, S., Lei, R., Wu, J., Shan, J., Hu, Z., Chen, L., Ren, X., Yao, L., Wang, J., Wang, X."Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer". Oncology Letters 14, no. 5 (2017): 5719-5726. https://doi.org/10.3892/ol.2017.6963
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang S, Lei R, Wu J, Shan J, Hu Z, Chen L, Ren X, Yao L, Wang J, Wang X, Wang X, et al: Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer. Oncol Lett 14: 5719-5726, 2017.
APA
Zhang, S., Lei, R., Wu, J., Shan, J., Hu, Z., Chen, L. ... Wang, X. (2017). Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer. Oncology Letters, 14, 5719-5726. https://doi.org/10.3892/ol.2017.6963
MLA
Zhang, S., Lei, R., Wu, J., Shan, J., Hu, Z., Chen, L., Ren, X., Yao, L., Wang, J., Wang, X."Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer". Oncology Letters 14.5 (2017): 5719-5726.
Chicago
Zhang, S., Lei, R., Wu, J., Shan, J., Hu, Z., Chen, L., Ren, X., Yao, L., Wang, J., Wang, X."Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer". Oncology Letters 14, no. 5 (2017): 5719-5726. https://doi.org/10.3892/ol.2017.6963
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